2018
DOI: 10.1002/cpt.1202
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Battling the HIV/AIDS Epidemic: Triumphs and Barriers

Abstract: Worldwide, over 77 million people have been infected by human immunodeficiency virus (HIV) but its cure remains elusive. Once considered a fatal disease, advances in antiretroviral therapy (ART) have dramatically increased the life expectancy of infected persons. Much progress has been made in the development and utilization of combination ART and preventative pre‐exposure prophylaxis products, however, numerous obstacles prevent eradication. Clinical pharmacologists along with world health organizations conti… Show more

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Cited by 3 publications
(3 citation statements)
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“…Waitt et al (2018) show that mother-to-child transmission in women with a viral load reduced by therapy allows non-transmission to the child. The results of this study have also been confirmed as regards the infection between serum-discordant couples, also indicating the time necessary before zeroing the viral load of the subject affected by HIV (Bavinton et al, 2018;Safier & Sauer, 2017;Woodson, 2018;McColl, Kojovic, & Piquette-Miller, 2018). The communication of this element linked to the treatment and elimination of the possible transmission between serum-discordant individuals in antiretroviral therapy thus becomes an essential element in communication towards the citizens.…”
Section: Hiv People Under Therapysupporting
confidence: 69%
“…Waitt et al (2018) show that mother-to-child transmission in women with a viral load reduced by therapy allows non-transmission to the child. The results of this study have also been confirmed as regards the infection between serum-discordant couples, also indicating the time necessary before zeroing the viral load of the subject affected by HIV (Bavinton et al, 2018;Safier & Sauer, 2017;Woodson, 2018;McColl, Kojovic, & Piquette-Miller, 2018). The communication of this element linked to the treatment and elimination of the possible transmission between serum-discordant individuals in antiretroviral therapy thus becomes an essential element in communication towards the citizens.…”
Section: Hiv People Under Therapysupporting
confidence: 69%
“…Additionally, over half of the approved antivirals are used to treat HIV. After the approval of the first antiviral for HIV in 1987, AIDS-related deaths have decreased by about 60%-80% (Andrei, 2021;McColl et al, 2018). However, AIDS still accounts for one million deaths annually.…”
Section: Antiviral Drugsmentioning
confidence: 99%
“…The development of effective HIV treatments was remarkable in speed and success, boosting antiviral research. After the approval of the first antiretroviral drug in 1987, a breakthrough in HIV therapy was the introduction in mid-1990's of HAART able to reduce AIDSrelated deaths by 60-80% (30). Although tremendous efforts have been done in antiretroviral therapy, culminating in the one-pill once-a-day regimens, there are still about one million people dying of AIDS per year.…”
Section: Antivirals: Successful Stories and Future Stepsmentioning
confidence: 99%