Battery-free, tuning circuit–inspired wireless sensor systems for detection of multiple biomarkers in bodily fluids

Liu, Tzu-Li; Yan, Dong; Chen, Shulin; Jie, Zhou; Ma, Zhenqiang; Li, Jinghua

doi:10.1126/sciadv.abo7049

Cited by 21 publications

(16 citation statements)

References 60 publications

(72 reference statements)

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“…Near-field technologies are characterized by short ranges and low data rates. Established protocols include radio-frequency identification (RFID) 796,803,813,814 and near-field communication (NFC), 815 for instance, while other near-field protocols designed for specific sensors have been reported as well, 622,816,817 electronics. 818 However, near-field technologies are sensitive to transmitter-receiver misalignment and limited by the short range of operation (usually <5 cm).…”

Section: Sensor Connectivitymentioning

confidence: 99%

“…Near-field technologies are characterized by short ranges and low data rates. Established protocols include radio-frequency identification (RFID) ,,, and near-field communication (NFC), for instance, while other near-field protocols designed for specific sensors have been reported as well, ,, which require specially designed readers. These technologies have the advantage of supporting wireless power in addition to data transfer, and are therefore particularly well-suited to operate passive sensors with no battery and minimal electronics .…”

Section: Sensor Connectivitymentioning

confidence: 99%

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Technology Roadmap for Flexible Sensors

et al. 2023

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Humans rely increasingly on sensors to address grand challenges and to improve quality of life in the era of digitalization and big data. For ubiquitous sensing, flexible sensors are developed to overcome the limitations of conventional rigid counterparts. Despite rapid advancement in bench-side research over the last decade, the market adoption of flexible sensors remains limited. To ease and to expedite their deployment, here, we identify bottlenecks hindering the maturation of flexible sensors and propose promising solutions. We first analyze challenges in achieving satisfactory sensing performance for real-world applications and then summarize issues in compatible sensor-biology interfaces, followed by brief discussions on powering and connecting sensor networks. Issues en route to commercialization and for sustainable growth of the sector are also analyzed, highlighting environmental concerns and emphasizing nontechnical issues such as business, regulatory, and ethical considerations. Additionally, we look at future intelligent flexible sensors. In proposing a comprehensive roadmap, we hope to steer research efforts towards common goals and to guide coordinated development strategies from disparate communities. Through such collaborative efforts, scientific breakthroughs can be made sooner and capitalized for the betterment of humanity.

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Section: Sensor Connectivitymentioning

confidence: 99%

Section: Sensor Connectivitymentioning

confidence: 99%

Technology Roadmap for Flexible Sensors

et al. 2023

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“…Nonfaradaic EIS was used to monitor the dose response of both targets and the platform reported detection ranges of 1–256 ng/mL of cortisol and 1–256 pg/mL of NPY. Based on the concept of nonfaradaic impedance, a tuning circuit–inspired wireless serotonin aptasensor was developed on gold electrodes (Figure a) . Binding of serotonin to the aptamer induces a conformational change which modulates the surface potential within the electrical double layer.…”

Section: Biosensor Mechanismsmentioning

confidence: 99%

“…a , A wearable tuning circuit-inspired wireless aptasensor on gold electrode for serotonin detection in biofluids. Reproduced with permission from ref . Copyright 2022 The American Association for the Advancement of Science.…”

Section: Biosensor Mechanismsmentioning

confidence: 99%

“…Based on the concept of nonfaradaic impedance, a tuning circuit−inspired wireless serotonin aptasensor was developed on gold electrodes (Figure 12a). 301 Binding of serotonin to the aptamer induces a conformational change which modulates the surface potential within the electrical double layer. The sensing interface is coupled with a pair of varactor diodes and a coil to form an inductor-capacitor (LC) resonance circuit.…”

Section: The Emerging Sweat Sensors Based On Bioaffinity Recognitionmentioning

confidence: 99%

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Skin-Interfaced Wearable Sweat Sensors for Precision Medicine

Min

et al. 2023

Chem. Rev.

200

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Wearable sensors hold great potential in empowering personalized health monitoring, predictive analytics, and timely intervention toward personalized healthcare. Advances in flexible electronics, materials science, and electrochemistry have spurred the development of wearable sweat sensors that enable the continuous and noninvasive screening of analytes indicative of health status. Existing major challenges in wearable sensors include: improving the sweat extraction and sweat sensing capabilities, improving the form factor of the wearable device for minimal discomfort and reliable measurements when worn, and understanding the clinical value of sweat analytes toward biomarker discovery. This review provides a comprehensive review of wearable sweat sensors and outlines stateof-the-art technologies and research that strive to bridge these gaps. The physiology of sweat, materials, biosensing mechanisms and advances, and approaches for sweat induction and sampling are introduced. Additionally, design considerations for the system-level development of wearable sweat sensing devices, spanning from strategies for prolonged sweat extraction to efficient powering of wearables, are discussed. Furthermore, the applications, data analytics, commercialization efforts, challenges, and prospects of wearable sweat sensors for precision medicine are discussed.

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A “Two‐Part” Resonance Circuit based Detachable Sweat Patch for Noninvasive Biochemical and Biophysical Sensing

Yan

Liu

Chen

et al. 2022

Adv Funct Materials

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Wearable electronics play important roles in noninvasive, continuous, and personalized monitoring of multiple biosignals generated by the body. To unleash their full potential for the next-generation human-centered bio-integrated electronics, wireless sensing capability is a desirable feature. However, state-of-the-art wireless sensing technologies exploit rigid and bulky electronic modules for power supply, signal generation, and data transmission. This study reports a battery-free device technology based on a "two-part" resonance circuit model with modularized, physically separated, and detachable functional units for magnetic coupling and biosensing. The resulting platform combines advantages of electronics and microfluidics with low cost, minimized form factors, and improved performance stability. Demonstration of a detachable sweat patch capable of simultaneous recording of cortisol concentration, pH value, and temperature highlights the potential of the "two-part" circuit for advanced, transformative biosensing. The resulting wireless sensors provide a new engineering solution to monitoring biosignals through intimate and seamless integration with skin surfaces.

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Battery-free, tuning circuit–inspired wireless sensor systems for detection of multiple biomarkers in bodily fluids

Cited by 21 publications

References 60 publications

Technology Roadmap for Flexible Sensors

Technology Roadmap for Flexible Sensors

Skin-Interfaced Wearable Sweat Sensors for Precision Medicine

A “Two‐Part” Resonance Circuit based Detachable Sweat Patch for Noninvasive Biochemical and Biophysical Sensing

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