Batrachotoxin induced axonal necrosis in peripheral nerves

Moore, George R.; Boegman, R.J.; Robertson, David; Riopelle, Richard J.

doi:10.1016/0006-8993(81)90383-8

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2010

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Cited by 9 publications

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“…BTX blocks axonal transport and induces axonal necrosis in a Na + dependent manner Boegman and Riopelle (1980) Hudson et al (1984) Deshpande et al (1981) Moore et al (1981) Worth and Ochs (1982). A subarachnoid injection of BTX into the spinal cord causes paraplegia in rats paraplegic due myelopathic damage Garcia et al (1978).…”

Section: Introductionmentioning

confidence: 99%

Batrachotoxin

Cataldi¹

2010

xPharm: The Comprehensive Pharmacology Reference

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Section: Introductionmentioning

confidence: 99%

Batrachotoxin

Cataldi¹

2010

xPharm: The Comprehensive Pharmacology Reference

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Alkaloids of Neotropical Poison Frogs (Dendrobatidae)

Daly

1982

Fortschritte Der Chemie Organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products

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Acute stages of batrachotoxin-induced neuropathy: a morphologic study of a sodium-channel toxin

et al. 1986

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The acute effects of batrachotoxin, a steroidal neurotoxin which opens the membrane sodium channel, were observed morphologically at various time points up to 3 h after injection into rat peroneal nerve. Three changes were found. First, there was massive swelling of the axon at the node of Ranvier accompanied by retraction of paranodal myelin. Second, a similar swelling of unmyelinated axons was seen. Third, extracellular fluid accumulated along the internode in the adaxonal space, the intraperiod line of myelin and, rarely, the external mesaxon, with concomitant shrinkage of the axon. The first two changes might be explained on the basis of massive shift of sodium through the batrachotoxin-modified sodium channel into the axon and subsequent osmotic shift of fluid. The reason for the third change is not clear but probably also has a ionic basis.

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Batrachotoxin induced axonal necrosis in peripheral nerves

Cited by 9 publications

References 13 publications

Batrachotoxin

Batrachotoxin

Alkaloids of Neotropical Poison Frogs (Dendrobatidae)

Acute stages of batrachotoxin-induced neuropathy: a morphologic study of a sodium-channel toxin

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