Batch Crystallizers

Tavare, Narayan S.

doi:10.1515/revce.1991.7.3-4.211

Cited by 11 publications

(9 citation statements)

References 86 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The choice of the constant k reflects the different weighing to be placed on the size distribution. A value of k ‫ס‬ 0.01 was found to give growth rates similar to those estimated from the change with time of the position of the peaks in the crystal size distributions [e.g., this compares with k ‫ס‬ 1.0 used by Tavare (1991) but for a less defined size distribution]. The nucleation rates obtained agreed with those estimated independently from the rate of change in overall number of crystals.…”

Section: Methodssupporting

confidence: 72%

See 1 more Smart Citation

Nucleation and growth of microbial lipase crystals from clarified concentrated fermentation broths

Jacobsen

Garside

Hoare

1998

Biotechnol. Bioeng.

View full text Add to dashboard Cite

Bulk crystallization is emerging as a new industrial operation for protein recovery. Characterization of bulk protein crystallization is more complex than protein crystallization for structural study where single crystals are grown in flow cells. This is because both nucleation and crystal growth processes are taking place while the supersaturation falls. An algorithm is presented to characterize crystallization using the rates of the two kinetic processes, nucleation and growth. The values of these rates allow ready comparison of the crystallization process under different operating conditions. The crystallization, via adjustment to the isoelectric pH of a fungal lipase from clarified fermentation broth, is described for a batch stirred reactor. A maximum nucleation rate of five to six crystals formed per microliter of suspension per second and a high power dependency (≈11) on the degree of supersaturation were found. The suspended protein crystals were found to grow at a rate of up to 15–20 nm/s and also to exhibit a high power dependency (≈6) of growth rate on the degree of supersaturation. © 1998 John Wiley & Sons, Inc. Biotechnol Bioeng 57: 666–675, 1998

show abstract

Section: Methodssupporting

confidence: 72%

“…The s-plane analysis was carried out as described by Tavare and Garside (1986) and Tavare (1991). The limits for the Laplace transform parameter were selected as s ‫ס‬ 0 and s ‫ס‬ k ⅐ 0 / 1 , where is the moment of the crystal size distribution.…”

Section: Methodsmentioning

confidence: 99%

Nucleation and growth of microbial lipase crystals from clarified concentrated fermentation broths

Jacobsen

Garside

Hoare

1998

Biotechnol. Bioeng.

View full text Add to dashboard Cite

show abstract

“…Parameter estimation based on transient batch crystallization is an attractive alternative to the MSMPR method. Tavare [179] summarizes the advantages of the batch crystallizer: a large number of operating variables can be studied in a relatively short time and a batch crystallizer can be successfully operated with a minimum development time and investment.…”

Section: Parameter Estimationmentioning

confidence: 99%

Model identification and control of solution crystallization processes: a review

Rawlings¹,

Miller²,

Witkowski³

1993

Ind. Eng. Chem. Res.

368

273

View full text Add to dashboard Cite

“…Much is known about crystal-Ž lization fundamentals Bamforth, 1965;Jancic anďǴ rootscholten, 1984;Rousseau, 1987;Randolph and Larson, 1988;Nyvlt, 1992;Sohnel and Garside, 1992;Mullin, 1993; . Myerson, 1993;Tavare, 1991Tavare, , 1995 Recently, there also has been a great deal of interest in examining crystallization systems from the perspective of process systems engineering. The aim is to come up with a reliable, optimal process while minimizing development time and effort.…”

Section: Introductionmentioning

confidence: 99%