Bat Nipah Virus, Thailand

Wacharapluesadee, Supaporn; Lumlertdacha, Boonlert; Boongird, Kalyanee; Wanghongsa, Sawai; Chanhome, Lawan; Rollin, Pierre E.; Stockton, Patrick C.; Rupprecht, Charles E.; Ksiazek, Thomas G.; Hemachudha, Thiravat

doi:10.3201/eid1112.050613

Cited by 217 publications

(190 citation statements)

References 12 publications

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“…fruit bats, which are distributed across the Indo-Pacifi c region from Madagascar eastward to the South Pacifi c islands (5). Evidence of henipavirus infection has been reported in Pteropus bats from Malaysia, Bangladesh, Australia, Thailand, Cambodia, Indonesia, and Madagascar, which supports the theory that these bats have co-evolved with henipaviruses (6)(7)(8).…”

supporting

confidence: 59%

HenipavirusInfection in Fruit Bats (Pteropus giganteus), India

Epstein

Prakash

Smith³

et al. 2008

Emerg. Infect. Dis.

136

114

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supporting

confidence: 59%

HenipavirusInfection in Fruit Bats (Pteropus giganteus), India

Epstein

Prakash

Smith³

et al. 2008

Emerg. Infect. Dis.

136

114

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“…Nevertheless, in addition to these countries, the virus has been detected in fruit bats or the bats were seropsitive to NiV antibodies from Cambodia [79], Thailand [90], Indonesia [81], India [23,99], Madagascar in Southern Africa [41] and Ghana in West Africa [22,37]. P. giganteus is the only Pteropus species present in Bangladesh [59].…”

Section: Historical Backgroundmentioning

confidence: 99%

Nipah virus infection: current scenario

et al. 2013

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“…54,65,67,89 The natural reservoir host of NiV is the Pteropus bats. 11,12,56,62,74,90 Unlike notable viral agents of biodefense concern, such as smallpox or Ebola virus, NiV can be isolated from natural hosts 11,73 and readily grown in cell culture to high titers.…”

Section: Nipah Virusmentioning

confidence: 99%

Henipavirus: A Review of Laboratory Animal Pathology

Williamson¹,

Torres-Vélez

2010

Vet Pathol

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The genus Henipavirus contains two members-Hendra virus (HeV) and Nipah virus (NiV)-and each can cause fatal disease in humans and animals. HeV and Niv are currently classified as biosafety level 4, and NiV is classified as a category C priority pathogen. The aim of this article is to discuss the pathology of laboratory animal models of henipavirus infection and to assess their suitability as animal models for the development and testing of human therapeutics and vaccines. There has been considerable progress in the development of animal models for henipavirus disease. Suitable animal models include the golden hamster, ferrets, cats, and pigs, which develop disease resembling that observed in humans. Guinea pigs are a less reliable model for henipavirus disease, but they do develop henipavirus-induced encephalitis. Because human efficacy studies with henipaviruses are not permitted, animal studies are critical for the development of antiviral therapeutics and vaccines. Current research indicates that passive immunotherapy using monoclonal antibodies is protective of ferrets against NiV infection and that passive immunotherapy using NiV antibodies protects hamsters from HeV. Recombinant vaccines have been used to protect cats and pigs against NiV infection. Ribavirin and 6-aza-uridine were able to delay but not prevent NiV-induced mortality in hamsters. Further research is needed to develop a model and therapy for late-onset henipavirus encephalitis.

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Bat Nipah Virus, Thailand

Abstract: Surveillance for Nipah virus (NV) was conducted in Thailand's bat population. Immunoglobulin G antibodies to NV were detected with enzyme immunoassay in 82 of 1,304 bats. NV RNA was found in bat saliva and urine. These data suggest the persistence of NV infection in Thai bats.

Cited by 217 publications

References 12 publications

HenipavirusInfection in Fruit Bats (Pteropus giganteus), India

HenipavirusInfection in Fruit Bats (Pteropus giganteus), India

Nipah virus infection: current scenario

Henipavirus: A Review of Laboratory Animal Pathology

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