Bat Flight and Zoonotic Viruses

O’Shea, Thomas J.; Cryan, Paul M.; Cunningham, Andrew A.; Fooks, Anthony R.; Hayman, David T. S.; Luis, Angela D.; Peel, Alison J.; Plowright, Raina K.; Wood, James

doi:10.3201/eid2005.130539

Cited by 296 publications

(309 citation statements)

References 38 publications

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“…The less-investigated first line of defence of the immune response, the acute phase reaction, contributes to the early control of infections and may have influenced bat coevolution with a wide diversity of pathogens that are highly virulent in other species. What little is known about bat acute phase response suggests that they are no different than other mammals [1,4] although there may be novel adaptations to successfully cope with infections [3,4].…”

Section: Introductionmentioning

confidence: 99%

No fever and leucocytosis in response to a lipopolysaccharide challenge in an insectivorous bat

et al. 2015

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Bat immune systems may allow them to respond to zoonotic agents more efficiently than other mammals. As the first line of defence, the taxonomically conserved acute phase immune reaction of leucocytosis and fever is crucial for coping with infections, but it is unknown if this response is a key constituent to bat immunological success. We investigated the acute phase reaction to a standard lipopolysaccharide (LPS) challenge in Pallas's mastiff bats ( Molossus molossus ). Challenged bats lost mass, but in contrast to other mammals showed no leucocytosis or fever. There also was no influence on body temperature reduction during torpor. When compared to recent genome-wide assays for constituent immune genes, this lack of a conserved fever response to LPS contributes to a clearer understanding of the innate immune system in bat species and of the coevolution of bats with a wide diversity of pathogens.

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Section: Introductionmentioning

confidence: 99%

No fever and leucocytosis in response to a lipopolysaccharide challenge in an insectivorous bat

et al. 2015

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“…In fact, Leroy et al (2006) postulated that great apes might be contaminated while touching bat placental tissues and biological fluids, during parturition. Bat's ability for long distance flying provides an intensive selective force for coexistence with viral parasites through a daily cycle that elevates metabolism and body temperature analogous to the febrile response in other mammals (O'Shea et al, 2014). These factors imply a large diversity of epidemiological situations according to the virus, the bat reservoir species and the region.…”

Section: The Probable Role Of Animals Involved In Filoviral Hemorrhagmentioning

confidence: 99%

Chiropteran and Filoviruses in Africa: Unveiling an ancient history

Sylla¹,

Pourrut²,

Diatta³

et al. 2015

Afr. J. Microbiol. Res.

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“…However, only few viral diseases such as SARS, MERS, Ebola virus disease etc are transmitted from bats to human (Moratelli & Calisher, 2015). Because a large proportions of bats under mammalian species (about 20%), their diverse habitats, biology and natural history, it assumed that bats may harbor several other viruses of human and animal importance (O'Shea et al, 2014;Brook & Dobson, 2015).…”

Section: Bats and Emerging Virusesmentioning

confidence: 99%