Basosquamous Carcinoma

Basosquamous cell carcinoma in organ transplant patients: A clinicopathologic study

“…In the population at large, 30% to 52% of patients with BSCC had already been treated for other carcinomas, 70% of which were BCC. 3,34 As previously reported for other NMSC, we found that patients transplanted before the age of 40 years J AM ACAD DERMATOL VOLUME 66, NUMBER 5 develop BSCC more frequently on the trunk compared with those grafted after the age of 40 years. 14,22 BSCC from two OTRs grafted before the age of 25 years were located on the trunk, whereas 8 of 9 of the BSCC in OTRs grafted after the age of 40 years developed on the head and neck.…”

“…[2][3][4][5][6][7][8] Several reports have suggested that BSCC behave biologically similarly to squamous cell carcinoma (SCC), [2][3][4]6,9,10 with a metastatic rate reaching 12%. 9 Abbreviations used: Organ transplant recipients (OTRs) are at highly increased risk to develop various skin malignancies, mainly SCC and BCC, [11][12][13] collectively referred to as nonmelanoma skin cancers (NMSC).…”

AAD/ACMS/ASDSA/ASMS 2012 appropriate use criteria for Mohs micrographic surgery: A report of the American Academy of Dermatology, American College of Mohs Surgery, American Society for Dermatologic Surgery Association, and the American Society for Mohs Surgery

“…The following additional search limitations were placed on the evidence review: In total, 161 primary articles were identified and analyzed for the development of the supporting evidence tables for the MMS AUC: 53 for basal cell carcinoma (BCC), 6-58 63 for squamous cell carcinoma (SCC), 6,[8][9][10]13,15,16,[18][19][20][21]23,24,29,36,[39][40][41][42]45,46,48,49,54, 23 for LM and melanoma in situ, 10 10,103,[182][183][184][185][186] In the majority of publications, more than 1 neoplasm was reported per study.…”

Basal cell carcinoma vs basaloid squamous cell carcinoma of the skin: an immunohistochemical reappraisal

“…That statement specifically applies to "metatypical" BCC, in which a higher level of squamoid differentiation is observed microscopically. The latter lesion must be distinguished from both BSCC and basosquamous carcinoma, which are potentially-metastasizing neoplasms that truly exhibit a squamous lineage, in part or globally (13)(14)(15).…”

“…BSCC was first described as such in the upper aerodigestive tract by Wain et al in 1986 and has been well-characterized since then (12)(13)(14). Studies comparing cutaneous and noncutaneous lesions of this type have shown morphological and immunophenotypic similarities regardless of anatomic site (15)(16)(17)(18)(19)(20).…”