Basophils balance healing after myocardial infarction via IL-4/IL-13

Sicklinger, Florian; Meyer, Ingmar Sören; Li, Xue; Radtke, Daniel; Dicks, Severin; Kornadt, Moritz P.; Mertens, Claudia; Meier, Julia K.; Lavine, Kory J.; Zhang, Yunhang; Kuhn, Tim Christian; Terzer, Tobias; Patel, Jyoti; Boerries, Melanie; Schramm, Gabriele; Frey, Norbert; Katus, Hugo A.; Voehringer, David; Leuschner, Florian

doi:10.1172/jci136778

Cited by 56 publications

(70 citation statements)

References 47 publications

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“…Jin G, et al concluded that N4 acetylcytidine plays a key role on the cancer development, inflammation responses and immunology regulations at same time 40 . The deeper mechanism of their mutual regulation needs further study, and the potential causal effects of nutritional status on immune response and the development of HCC would also be inferred based on a large cohort under the Mendelian Randomization framework in the era of post-Genome-Wide Association Studies (GWAS) and precision medicine 41 – 44 .…”

Section: Discussionmentioning

confidence: 99%

Combined prognostic nutritional index and albumin-bilirubin grade to predict the postoperative prognosis of HBV-associated hepatocellular carcinoma patients

Liang

Wang

et al. 2021

Sci Rep

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This study aims to evaluate the predictive value of the prognostic nutritional index (PNI) and albumin-bilirubin grade (ALBI) for the postoperative prognosis of hepatitis B virus-associated hepatocellular carcinoma (HBV-HCC) patients undergoing radical hepatectomy (RH). Besides, we seek to identify novel prognosis indicators for HBV-HCC patients. Between April 2009 and March 2015, this work enrolled 868 patients diagnosed with HBV-HCC and undergoing RH in the Liver Surgery Department, West China Hospital, Sichuan University (WCHSU). The basic information, laboratory examination indicators, pathological reports, and follow-up data of patients were included. SPSS 22.0 statistical software was used for statistical data analyses. Platelet (PLT), alpha-fetoprotein (AFP), maximum diameter (max-D), number of tumors (Number), degree of differentiation (DD), Microvascular invasion situation (MVI), satellite focus situation (SF), PNI, and ALBI were the independent risk factors for both overall survival (OS) and disease-free survival (DFS) of HBV-HCC patients undergoing RH. Taking PNI = 46 and ALBI = − 2.80 as cut-off values, the OS and DFS of the PNI-high group were significantly higher than those of the PNI-low group. Meanwhile, the OS and DFS of the ALBI-low group were significantly higher than those of the ALBI-high group; the OS and DFS of the PNI-high + ALBI-low group were significantly higher than those of the PNI-low + ALBI-high group. Xie prognostic index (XPI) was the independent risk factor for both OS and DFS of HBV-HCC patients undergoing RH. The OS and DFS of the XPI-high group were significantly higher than those of the XPI-low group. This paper reveals that preoperative PNI and ALBI can predict the OS and DFS of HBV-HCC patients undergoing RH. Their impact on the prognosis of HBV-HCC patients is insignificant, however, it cannot be ignored. XPI can precisely predict the prognosis of HBV-HCC patients undergoing RH, nonetheless, its effect requires additional research for validation.

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Section: Discussionmentioning

confidence: 99%

Combined prognostic nutritional index and albumin-bilirubin grade to predict the postoperative prognosis of HBV-associated hepatocellular carcinoma patients

Liang

Wang

et al. 2021

Sci Rep

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“…Sicklinger et al (15) have elegantly demonstrated the central importance of cardiac basophils and basophil-derived IL-4 and IL-13 in the inflammatory and healing response after MI. This heretofore unappreciated role for this relatively sparse…”

Section: Discussionmentioning

confidence: 99%

“…In this issue of the JCI, Sicklinger et al (15) report a different role for basophils (Figure 1). The rare granulocyte population classically associated with allergic responses and immunity to parasites is involved in the regulation of post-MI healing and the resolution response.…”

Section: Another Understanding Of Basophils After MImentioning

confidence: 98%

“…Monocytes and macrophages are the most abundant immune cell type in the infarcted heart and thus the most prominent as innate immune effector cells (1,5); hence, the focus on their biological role and tissue responses and their potential as direct therapeutic targets is readily understandable. However, Sicklinger et al (15) have demonstrated that low-abundance cell populations (or subpopulations) in the heart, such as basophils, may have disproportionate effects (relative to cell number) on cardiac repair and remodeling. Secreted cytokines and mediators referable to these populations may amplify cellular responses ( 16) that will subsequently affect the predominant monocyte/macrophage phenotype.…”

Section: Conceptual and Translational Implicationsmentioning

confidence: 99%

“…Reparative macrophage differentiation is facilitated by efferocytosis and requires the nuclear hormone receptor Nr4a1. In this issue of the JCI, Sicklinger et al (15) report a central role for basophils in the healing process, in large part related to their secretion of IL-4 and IL-13, which in turn promotes reparative macrophage differentiation and inflammation resolution. Hence, basophils play an essential role in the fidelity of post-MI cardiac repair and the subsequent limitation of long-term adverse cardiac remodeling.…”

Section: Conceptual and Translational Implicationsmentioning

confidence: 99%

See 2 more Smart Citations

Healing and repair after myocardial infarction: the forgotten but resurgent basophil

Prabhu¹

2021

Journal of Clinical Investigation

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Macrophage‐mediated heart repair and remodeling: A promising therapeutic target for post‐myocardial infarction heart failure

Yin,

Chen,

Wang

et al. 2024

Journal Cellular Physiology

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Heart failure (HF) remains prevalent in patients who survived myocardial infarction (MI). Despite the accessibility of the primary percutaneous coronary intervention and medications that alleviate ventricular remodeling with functional improvement, there is an urgent need for clinicians and basic scientists to further reveal the mechanisms behind post‐MI HF as well as investigate earlier and more efficient treatment after MI. Growing numbers of studies have highlighted the crucial role of macrophages in cardiac repair and remodeling following MI, and timely intervention targeting the immune response via macrophages may represent a promising therapeutic avenue. Recently, technology such as single‐cell sequencing has provided us with an updated and in‐depth understanding of the role of macrophages in MI. Meanwhile, the development of biomaterials has made it possible for macrophage‐targeted therapy. Thus, an overall and thorough understanding of the role of macrophages in post‐MI HF and the current development status of macrophage‐based therapy will assist in the further study and development of macrophage‐targeted treatment for post‐infarction cardiac remodeling. This review synthesizes the spatiotemporal dynamics, function, mechanism and signaling of macrophages in the process of HF after MI, as well as discusses the emerging bio‐materials and possible therapeutic agents targeting macrophages for post‐MI HF.

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Basophils balance healing after myocardial infarction via IL-4/IL-13

Cited by 56 publications

References 47 publications

Combined prognostic nutritional index and albumin-bilirubin grade to predict the postoperative prognosis of HBV-associated hepatocellular carcinoma patients

Combined prognostic nutritional index and albumin-bilirubin grade to predict the postoperative prognosis of HBV-associated hepatocellular carcinoma patients

Healing and repair after myocardial infarction: the forgotten but resurgent basophil

Macrophage‐mediated heart repair and remodeling: A promising therapeutic target for post‐myocardial infarction heart failure

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