Basonuclin as a cell marker in the formation and cycling of the murine hair follicle

Weiner, Lorin; Green, Howard

doi:10.1046/j.1432-0436.1998.6350263.x

Cited by 25 publications

(11 citation statements)

References 46 publications

(85 reference statements)

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“…Immunofluorescent analyses were carried out as described (Weiner and Green, 1998) with little modification. Frozen sections were blocked in SuperBlock T20 PBS blocking buffer (Thermo Scientific), incubated sequentially with rabbit polyclonal anti-trichohyalin antibody (1:3000; the gift of Dr. George E. Rogers, University of Adelaide), goat-anti-rabbit IgG (1:2000; Santa Cruz Biotechnology), and streptavidin-CY3 conjugates (1:700, Sigma-Aldrich, Inc.), and counterstained with Hoechst dye 33258 (Fluka).…”

Section: Methodsmentioning

confidence: 99%

A pair of transmembrane receptors essential for the retention and pigmentation of hair

Han¹,

Beppu²,

Lee³

et al. 2012

Genesis

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Hair follicles are simple, accessible models for many developmental processes. Here, using mutant mice, we show that Bmpr2, a known receptor for bone morphogenetic proteins (Bmps), and Acvr2a, a known receptor for Bmps and activins, are individually redundant but together essential for multiple follicular traits. When Bmpr2/Acvr2a function is reduced in cutaneous epithelium, hair follicles undergo rapid cycles of hair generation and loss. Alopecia results from a failure to terminate hair development properly, as hair clubs never form, and follicular retraction is slowed. Hair regeneration is rapid due to premature activation of new hair-production programs. Hair shafts differentiate aberrantly due to impaired arrest of medullary-cell proliferation. When Bmpr2/Acvr2a function is reduced in melanocytes, gray hair develops, as melanosomes differentiate but fail to grow, resulting in organelle miniaturization. We conclude that Bmpr2 and Acvr2a normally play cell-type-specific, necessary roles in organelle biogenesis and the shutdown of developmental programs and cell division.

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Section: Methodsmentioning

confidence: 99%

A pair of transmembrane receptors essential for the retention and pigmentation of hair

Han¹,

Beppu²,

Lee³

et al. 2012

Genesis

Self Cite

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“…Basonuclin + + Weiner & Green [150] ΔNp63 + + Romano et al [151] K14 + + Sada et al [147] Outer bulge and SHG (is missing in inner bulge).…”

Section: Gata6mentioning

confidence: 99%

Functional anatomy of the hair follicle: The Secondary Hair Germ

Panteleyev

2018

Experimental Dermatology

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The secondary hair germ (SHG)-a transitory structure in the lower portion of the mouse telogen hair follicle (HF)-is directly involved in anagen induction and eventual HF regrowth. Some crucial aspects of SHG functioning and ontogenetic relations with other HF parts, however, remain undefined. According to recent evidence (in contrast to previous bulge-centric views), the SHG is the primary target of anagen-inducing signalling and a source of both the outer root sheath (ORS) and ascending HF layers during the initial (morphogenetic) anagen subphase. The SHG is comprised of two functionally distinct cell populations. Its lower portion (originating from lower HF cells that survived catagen) forms all ascending HF layers, while the upper SHG (formed by bulge-derived cells) builds up the ORS. The predetermination of SHG cells to a specific morphogenetic fate contradicts their attribution to the "stem cell" category and supports SHG designation as a "germinative" or a "founder" cell population. The mechanisms of this predetermination driving transition of the SHG from "refractory" to the "competent" state during the telogen remain unknown. Functionally, the SHG serves as a barrier, protecting the quiescent bulge stem cell niche from the extensive follicular papilla/SHG signalling milieu. The formation of the SHG is a prerequisite for efficient "precommitment" of these cells and provides for easier sensing and a faster response to anagen-inducing signals. In general, the formation of the SHG is an evolutionary adaptation, which allowed the ancestors of modern Muridae to acquire a specific, highly synchronized pattern of hair cycling.

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“…In these studies, the Golgi apparatus was located apically in the epithelial cells and disintegrated into ribbons and small vesicles in those cells undergoing differentiation. In mouse epidermal keratinocytes, basonuclin is mainly cytoplasmic, in contrast to the hair follicular keratinocytes, in which basonuclin is predominantly nuclear [6,25]. 226 Fig.…”

Section: Cytoplasmic Basonuclin In the Lens Epitheliummentioning

confidence: 99%

“…An earlier report indicated that in epidermis it was present in the nuclei of basal keratinocytes [20]. More recent work suggested that in murine epidermis, basonuclin can also be predominantly a cytoplasmic protein [7,25]. In both cases, basonuclin was confined strictly to the basal cells.…”

Section: Introductionmentioning

confidence: 95%

Basonuclin in murine corneal and lens epithelia correlates with cellular maturation and proliferative ability

1999

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Basonuclin as a cell marker in the formation and cycling of the murine hair follicle

Cited by 25 publications

References 46 publications

A pair of transmembrane receptors essential for the retention and pigmentation of hair

A pair of transmembrane receptors essential for the retention and pigmentation of hair

Functional anatomy of the hair follicle: The Secondary Hair Germ

Basonuclin in murine corneal and lens epithelia correlates with cellular maturation and proliferative ability

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