The Matoush uranium deposit is situated in the Paleoproterozoic Otish Basin, northern Quebec, Canada, and is hosted by the Indicator Formation sandstones. Its sheet-like ore bodies are closely associated with the steeply dipping Matoush Fracture, which hosts mafic dykes and minor quartz-feldspar-tourmaline pegmatites. Regional diagenesis, involving oxidizing basinal fluids (δ 2 H ∼−15‰, δ 18 O ∼8‰), produced mostly illite and possibly leached U from accessory phases in the Indicator Formation sandstones. The bimodal Matoush dyke intruded the Indicator Formation along the Matoush Fracture, and the related metasomatism produced Cr-rich dravite and muscovite in both the dyke and the proximal sandstones. Uraninite formed when U 6+ in the basinal brine was reduced to U 4+ in contact with the mafic dyke and by Fe 2+ in Cr-dravite and Cr-muscovite, and precipitated together with eskolaite and hematite. Because of its unique characteristics, the Matoush deposit cannot be easily classified within the generally accepted classification of uranium deposits. Two of its main characteristics (unusual reduction mechanism, structural control) do not correspond to the sandstone-hosted group of deposits (unconformity type, tabular, roll front), in spite of uranium being derived from the Otish Group sandstones.