Basil polysaccharides: A review on extraction, bioactivities and pharmacological applications

Zhan, Yanfei; An, Xinin; Wang, Shuang; Sun, Mengjia; Zhou, Honglei

doi:10.1016/j.bmc.2019.115179

Cited by 55 publications

(49 citation statements)

References 65 publications

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“…[56] It is also part of Mediterranean diets especially in South of Europe, for example Italian and Greek cuisines. [57] Basil polysaccharides have been used for cancer treatment in traditional Chinese medicine, [58] and still is widely used in people , s lives. [59] Medicinal uses and potential health benefits in modern medicine industry…”

Section: Basil Nutritional Composition and Chemical Constituentsmentioning

confidence: 99%

Chemical components and pharmacological benefits of Basil (Ocimum basilicum): a review

Shahrajabian

Sun

Cheng

2020

International Journal of Food Properties

198

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Section: Basil Nutritional Composition and Chemical Constituentsmentioning

confidence: 99%

Chemical components and pharmacological benefits of Basil (Ocimum basilicum): a review

Shahrajabian

Sun

Cheng

2020

International Journal of Food Properties

198

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“…The perennial herb Ocimum basilicum (family Lamiaceae), commonly known as basil, is valued worldwide for its culinary uses, but its applications go well beyond that. Basil and its essential oil are often used in traditional medicine (Irondi et al 2016;Ezeani et al 2017;Bae et al 2020), cosmetics (Vivas Castaño et al 2016;Volpe et al 2018;Yeşil et al 2020), and pharmacology (Sestili et al 2018;Zhan et al 2020). Among the pharmacologically interesting compounds found in basil are linalool (Medeiros Venancio et al 2016), rosmarinic (Kwon et al 2019), oleanolic (OA; Qamar et al 2020) and ursolic acid (UA; Arshad Qamar et al 2010;Kümmritz et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Establishment and triterpenoid production of Ocimum basilicum cambial meristematic cells

Mehring

Haffelder

Chodorski

et al. 2020

Plant Cell Tiss Organ Cult

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The application of plant suspension culture to produce valuable compounds, such as the triterpenoids oleanolic acid and ursolic acid, is a well-established alternative to the cultivation of whole plants. Cambial meristematic cells (CMCs) are a growing field of research, often showing superior cultivation properties compared to their dedifferentiated cell (DDC) counterparts. In this work, the first-time establishment of O. basilicum CMCs is demonstrated. DDCs and CMCs were cultivated in shake flasks and wave-mixed disposable bioreactors (wDBRs) and evaluated regarding triterpenoid productivity and biomass accumulation. CMCs showed characteristic small vacuoles and were found to be significantly smaller than DDCs. Productivities of oleanolic and ursolic acid of CMCs were determined at 3.02 ± 0.76 mg/(l*d) and 4.79 ± 0.48 mg/(l*d) after 19 days wDBR cultivation, respectively. These values were consistently higher than any productivities determined for DDCs over the observed cultivation period of 37 days. Elicitation with methyl jasmonate of DDCs and CMCs in shake flasks resulted in increased product contents up to 48 h after elicitor addition, with the highest increase found in CMCs at 232.30 ± 19.33% (oleanolic acid) and 192.44 ± 18.23% (ursolic acid) after 48 h.

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“…Therefore, we tested the number of lymphocytes in mouse BALF and found that basil polysaccharide can signi cantly increase lymphocytes in the lungs (Fig 3H). Previous studies have also shown that BPS enhances T cells activation and antigen presentation within dendritic cells (DCs), thus enhancing the immune response and surveillance [21]. Next, we tested the CD4+ T lymphocyte subsets (Treg cells) in the BALF of experimental mice, and the results indicated that basil polysaccharide could increase the proportion of Treg cells in BALF (Fig 6A).…”

Section: Discussionmentioning

confidence: 80%

“…Studies have demonstrated that basil polysaccharide (BPS) is adopted to be the immunopotentiator for stimulating macrophages, protecting immune organs, while building the complement system for exerting immune enhancement effects. Moreover, basil polysaccharide exhibits good antibacterial activity [21]. BPS can also inhibit various bacteria infected in clinic [ 22 23].…”

Section: Introductionmentioning

confidence: 99%

Basil Polysaccharide Reverses Development of Experimental Model of Sepsis-Induced Secondary Staphylococcus Aureus Pneumonia

Chen

Wang

et al. 2021

Preprint

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Background: Basil polysaccharide (BPS) represents a main active ingredient extracted from Basil (Ocimum basilicum L.), which can regulate secondary bacterial pneumonia development in the process of sepsis-mediated immunosuppression.Methods: In this study, a dual model of sepsis-induced secondary pneumonia with cecal ligation and puncture and intratracheal instillation of Staphylococcus aureus or Pseudomonas aeruginosa was constructed.Results: The results indicated that BPS treated mice undergoing CLP showed resistance to secondary S. aureus pneumonia. Compared with the IgG treated group, BPS treated mice exhibited better survival rate along with higher bacterial clearance rate. Additionally, BPS treatment attenuated cell apoptosis, enhanced lymphocytes and macrophages recruitment to the lung, promoted pulmonary cytokine production, and significantly enhanced CC receptor ligand 4 (CCL4). Notably, recombinant CCL4 protein could enhance the protective effect on S. aureus-induced secondary pulmonary infection of septic mice, which indicated that BPS induced CCL4 partially mediated resistance to secondary bacterial pneumonia. In addition, BPS priming markedly promoted the phagocytosis of alveolar macrophages while killing S. aureus in vitro, which was related to the enhanced p38MAPK signal transduction pathway activation. Moreover, BPS also played a protective role in sepsis-induced secondary S. aureus pneumonia by inducing Treg cell differentiation.Conclusions: Collectively, these results shed novel lights on the BPS treatment mechanism in sepsis-induced secondary S. aureus pneumonia in mice.

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Basil polysaccharides: A review on extraction, bioactivities and pharmacological applications

Cited by 55 publications

References 65 publications

Chemical components and pharmacological benefits of Basil (Ocimum basilicum): a review

Chemical components and pharmacological benefits of Basil (Ocimum basilicum): a review

Establishment and triterpenoid production of Ocimum basilicum cambial meristematic cells

Basil Polysaccharide Reverses Development of Experimental Model of Sepsis-Induced Secondary Staphylococcus Aureus Pneumonia

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