Basidiobolomycosis: Case series

Jarie, Ahmed Al; Azraki, T. Al; Mohsen, I. Al; Jumaah, Suliman Al; Almutawa, Abdulmonem; Fahim, Y. Mohd; Shehri, Mohammed Al; Dayah, A. Abu; Aliyu, Ibrahim; Shabana, Medhat; Hussein, Mahmoud R.

doi:10.1016/j.mycmed.2010.11.002

Cited by 34 publications

(59 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…GIB has rarely been reported in the medical literature although sporadic cases have been reported worldwide (Vikram et al ., 2012). To our knowledge, 50 cases of GIB have been reported worldwide in addition to our current report (Al Jarie et al ., 2003, 2011; Al-Qahtani et al ., 2013; Al Saleem et al ., 2013; Bigliazzi et al ., 2004; Lyon et al ., 2001; Nemenqani et al ., 2009; Saadah et al ., 2012; Vikram et al ., 2012). Most of these cases were reported from tropical areas where the climate was warm and humid, and such a climate enhances the growth of the fungus, suggesting environmental contamination (Al Jarie et al ., 2003).…”

Section: Discussionmentioning

confidence: 99%

Gastrointestinal basidiobolomycosis with hepatic dissemination: a case report

2014

View full text Add to dashboard Cite

Introduction:Gastrointestinal basidiobolomycosis (GIB) is an emerging fungal infection with a few cases reported worldwide. It is caused by Basidiobolus ranarum, which does not usually invade blood vessels and rarely disseminates.Case presentation:We present a rare case of GIB with hepatic dissemination in a 12-year-old Yemeni boy living in southwestern Saudi Arabia. The initial provisional diagnosis was intestinal lymphoma, and a right hemicolectomy was carried out, but histopathological assessment ruled out lymphoma and suggested intestinal tuberculosis. Two weeks after starting antituberculous medications, the patient was referred to our hospital because of fever and right upper abdominal discomfort. There was leukocytosis with marked eosinophilia, and a liver biopsy showed evidence of B. ranarum infection. A second opinion by histopathological examination of resected tissues diagnosed colonic basidiobolomycosis. The patient was treated successfully with itraconazole.Conclusion:GIB is an emerging disease in southwestern Saudi Arabia and should be considered in a patient with an abdominal mass and eosinophilia coming from this region. Persistent elevation of leukocytes and eosinophils after surgical resection of the affected tissue could be used as a predictor of fungal dissemination. Further research is needed for a better understanding of GIB.

show abstract

Section: Discussionmentioning

confidence: 99%

Gastrointestinal basidiobolomycosis with hepatic dissemination: a case report

2014

View full text Add to dashboard Cite

show abstract

“…Basidiobolomycosis mostly manifests as subcutaneous infections, but progressively increased gastrointestinal and other systemic infections have been observed (9–12, 30). Gastrointestinal basidiobolomycosis (GIB) is an emerging health care hazard, especially among children in tropical countries.…”

Section: Discussionmentioning

confidence: 99%

“…The role of Basidiobolus ranarum in GIB has long been suspected (3, 22, 36, 37). Diagnosis of the majority of basidiobolomycosis cases is established on histological basis, fungal morphology and the Splendore-Hoeppli phenomenon (30, 34, 38, 39). Not all studies provided enough culture proven cases.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Basidiobolus haptosporus-likefungus as a causal agent of gastrointestinal basidiobolomycosis and its link to the common house gecko (Hemidactylus frenatus) as a potential risk factor

Bshabshe

et al. 2018

Preprint

View full text Add to dashboard Cite

Basidiobolus spp. are a significant causal agent of infections in man and animals including gastrointestinal basidiobolomycosis (GIB). Little information is available on how these infections are acquired or transmitted, apart from the postulation that environmental sources are implicated. This study aimed to identify Basidiobolus spp. from GIB patients and from the house gecko as a possible source of infection in Aseer, Saudi Arabia. Basidiobolus spp. were isolated from patient specimens (colonic mass biopsy) and from house gecko (gut contents) from Muhayil Aseer areas, in southern Saudi Arabia, using Sabouraud dextrose agar (SDA) which was incubated aerobically for up to three weeks at 30°C. Isolated fungi were initially identified using classical mycological tools and confirmed by sequence analysis of the large subunit ribosomal RNA gene. Cultured specimens from humans and geckos revealed phenotypically similar zygomycete-like fungi which conform to those of Basidiobolus species. The strains formed a monophyletic clade in the 28S ribosomal RNA gene phylogenetic tree. They shared 99.97% similarity with B. haptosporus and 99.97% with B. haptosporus var. minor but have a relatively remote similarity to B. ranarum (99.925%). One isolates from a gecko (L3) fall within the sub-clade encompassing B. haptosporus strain NRRL28635. The study strongly suggests a new and a serious causal agent of GIB related to Basidiobolus haptosporus. The isolation of identical Basidiobolus haptosporus-like strains from humans and lizards from one area is an important step towards identifying risk factors for GIB. Research is underway to screen more environmental niches and fully describe the Basidiobolus strains.

show abstract

“…It usually manifests with subcutaneous infection, gastrointestinal lesions and rarely with systemic affection. [5] GIB is an invasive fungal infection that leads to substantial morbidity and mortality and diagnostic confusion. [6] "The main differential diagnosis of GIB with granuloma includes inflammatory bowel disease, intestinal tuberculosis, sarcoidosis, amebiasis, and malignancy."…”

Section: Discussionmentioning

confidence: 99%

Untitled

Al-Qahtani¹

2017

IJGP

View full text Add to dashboard Cite

Gastrointestinal basidiobolomycosis (GIB) is an invasive fungal infection affecting immunocompetent children and young adults. Most of the reported cases are from the southwestern region of Saudi Arabia; it has a non-specific presentation which can mimic inflammatory bowel disease, gastrointestinal tuberculosis, and colon cancer. GIB usually affects the colon and small intestine while disseminated GIB is very rare. Liver involvement was reported in only 5 cases. We report here the case of a 22-year-old Saudi girl living in Jizan (southern region of Saudi Arabia) presented with disseminated gastrointestinal intramural and liver abscesses which were successfully treated with the aspiration of liver abscess and oral antifungal therapy (itraconazole). GIB diagnosis need a high index of suspicion and should be considered in patients from the southwestern region of Saudi Arabia with gastrointestinal intramural and liver abscesses. GIB is an emerging infection that might lead to diagnostic confusion, morbidity, and mortality.

show abstract

Basidiobolomycosis: Case series

Cited by 34 publications

References 13 publications

Gastrointestinal basidiobolomycosis with hepatic dissemination: a case report

Gastrointestinal basidiobolomycosis with hepatic dissemination: a case report

Basidiobolus haptosporus-likefungus as a causal agent of gastrointestinal basidiobolomycosis and its link to the common house gecko (Hemidactylus frenatus) as a potential risk factor

Untitled

Contact Info

Product

Resources

About