Abstract:Abstract:The use of non-invasive alternating magnetic field (AMF) on biocompatible, small sized iron oxide nanoparticles can be used for heat generation in magnetic hyperthermia or for contrast enhancement of biological tissue. However, the behavior of magnetic nanoparticle in the presence of magnetic field is restricted by their size, shape, surface defects, and coatings. Hence, it becomes imperative to closely monitor the magnetic properties of the nanoparticles as current novel formulations of nanoparticles… Show more
“…Ferromagnetic materials can be categorized into soft and hard magnets (Mody et al 2013 ). Soft magnets have a low coercivity (Hc), so they can be demagnetized at low magnetic field.…”
Section: Basics Of Magnetism In Magnetic Hyperthermiamentioning
confidence: 99%
“…When the coercivity becomes zero, the particles magnetize in the presence of an external magnetic field and revert to a non-magnetic state when the external magnetic field is removed (Fig. 3 ) (Mody et al 2013 ). Fig.…”
Section: Basics Of Magnetism In Magnetic Hyperthermiamentioning
Recent advances in nanomaterials science contributed to develop new
micro- and nano-devices as potential diagnostic and therapeutic tools in the field
of oncology. The synthesis of superparamagnetic nanoparticles (SPMNPs) has been
intensively studied, and the use of these particles in magnetic hyperthermia therapy
has demonstrated successes in treatment of cancer. However, some physical
limitations have been found to impact the heating efficiency required to kill cancer
cells. Moreover, the bio-safety of NPs remains largely unexplored. The primary goals
of this review are to summarize the recent progress in the development of magnetic
nanoparticles (MNPs) for hyperthermia, and discuss the limitations and advances in
the synthesis of these particles. Based on this knowledge, new perspectives on
development of new biocompatible and biofunctional nanomaterials for magnetic
hyperthermia are discussed.
“…Ferromagnetic materials can be categorized into soft and hard magnets (Mody et al 2013 ). Soft magnets have a low coercivity (Hc), so they can be demagnetized at low magnetic field.…”
Section: Basics Of Magnetism In Magnetic Hyperthermiamentioning
confidence: 99%
“…When the coercivity becomes zero, the particles magnetize in the presence of an external magnetic field and revert to a non-magnetic state when the external magnetic field is removed (Fig. 3 ) (Mody et al 2013 ). Fig.…”
Section: Basics Of Magnetism In Magnetic Hyperthermiamentioning
Recent advances in nanomaterials science contributed to develop new
micro- and nano-devices as potential diagnostic and therapeutic tools in the field
of oncology. The synthesis of superparamagnetic nanoparticles (SPMNPs) has been
intensively studied, and the use of these particles in magnetic hyperthermia therapy
has demonstrated successes in treatment of cancer. However, some physical
limitations have been found to impact the heating efficiency required to kill cancer
cells. Moreover, the bio-safety of NPs remains largely unexplored. The primary goals
of this review are to summarize the recent progress in the development of magnetic
nanoparticles (MNPs) for hyperthermia, and discuss the limitations and advances in
the synthesis of these particles. Based on this knowledge, new perspectives on
development of new biocompatible and biofunctional nanomaterials for magnetic
hyperthermia are discussed.
“…Even though the concept of using magnetic particles for drug delivery was proposed as far back as 1970, the field of magnetic drug delivery has only recently received much attention (Senyei et al 1978;Widder et al 1978). Usually (Mody et al 2013) therapeutic agents are attached to the surface of magnetic nanoparticles or encapsulated within a nanocomposite mixture of a polymer and magnetic nanoparticle. In this case they can be operated under the influence of very low values of applied magnetic field.…”
Section: Magnetic Nanoparticles For Drug Deliverymentioning
confidence: 99%
“…The domain structure of the magnetic materials has been drawn for simplicity. Copyrighted from reference (Mody et al 2013) as diagnostic and therapeutic agents (Liu et al 2011;Paliwal et al 2010). Any change in size and surface coating will modulate the magnetic properties such as Coercivity (Hc) of these nanospheres of the nanoparticles and hence can vary the effectiveness of these diagnostic as well as therapeutic agents.…”
Tumor hypoxia, or low oxygen concentration, is a result of disordered vasculature that lead to distinctive hypoxic microenvironments not found in normal tissues. Many traditional anti-cancer agents are not able to penetrate into these hypoxic zones, whereas, conventional cancer therapies that work by blocking cell division are not effective to treat tumors within hypoxic zones. Under these circumstances the use of magnetic nanoparticles as a drug delivering agent system under the influence of external magnetic field has received much attention, based on their simplicity, ease of preparation, and ability to tailor their properties for specific biological applications. Hence in this review article we have reviewed current magnetic drug delivery systems, along with their application and clinical status in the field of magnetic drug delivery.
“…Diagram of the relationship between coercive field and magnetic NPs size, discerning between single and multi-domain regimes, as well as the superparamagnetic and the ferromagnetic behaviour. Image modified from[24].…”
Production of permanent magnets is a complex process that implies very specific machinery able to perform very specific actions. Even though this problem has been approached by extrusion-based three-dimensional printing techniques, the resulting parts either have not been fully characterized or present low-resolution outputs. In this study we use the stereolithography three-dimensional printing technique to address this problem and demonstrate that it is possible to develop high-resolution polymer-based permanent magnets. We report an in-depth magnetic characterization of the produced materials, including magnetization of saturation, coercivity, magnetic relative permeability, magnetic behaviour, type of interaction between particles, and magnetic domain orientation. We have further demonstrated that this orientation can be rearranged. Obtaining contrasting properties of the developed materials opens the possibility of developing personalized, high-resolution devices that can be used in a wide range of fields such as micro-robotics, biotechnology, biomedicine, and medical science among many others.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
