Basics and Applications of Solid State Kinetics: A Pharmaceutical Perspective

Abstract

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Combined kinetic analysis of thermal degradation of polymeric materials under any thermal pathway

“…An alternative to isothermal experiment is the linear heating rate program, where temperature varies in a wide range of values while the thermal degradation is recorded as a function of the temperature. This linear heating rate program is the most widely used [28]. In any case, it is not uncommon to find in the literature a serious disagreement between the kinetic parameters calculated from data obtained under isothermal and non-isothermal conditions [26,29,30].…”

Thermal analysis of novel biphenylamide derivatives

“…An approach employed to investigate the nature of a given reaction in kinetic studies is to monitor how the activation energy value changes as a function of conversion [9][10][11]; conversion is the fraction of sample that has undergone some chemical or physical transformation. In the case of TG the conversion is related to the mass fraction remaining after a particular process, i.e.…”

Physicochemical Properties of Amorphous Roxithromycin Prepared by Quench Cooling of the Melt or Desolvation of a Chloroform Solvate

“…However, since the desolvation peak and transformation peak values are indistinguishable from the DSC thermograms of this solvate, the onset temperatures were used. Furthermore, the Kissinger method is a model-free method and does not require the assumption of a specific model for the calculation of E a (16). The use of the Kissinger method enables the determination of activation energy (E a ), without taking into account the mechanism that result in the transformation.…”