Basic Traditional Chinese Medicinal Compound for Adjuvant Treatment of Helicobacter pylori-Related Gastritis: Implication for Anti-H. pylori-Related Gastritis Drug Discovery
Abstract:This study was aimed at evaluating the efficacy of traditional Chinese medicine (TCM) in the adjuvant treatment of Helicobacter pylori-associated gastritis (HPAG) and exploring the molecular mechanism underlying the action of the basic TCM compounds against HPAG. Eight representative Chinese and British databases were combed for pertinent literature. In light of the basic principle of evidence-based medicine, this work rigorously stuck to the inclusion and exclusion of criteria so as to plump for qualified art… Show more
“…The majority of H. pylori-infected individuals experience persistently active gastritis that linked to Helicobacter pylori. In addition, changes in hormone secretion and gastric acid affect the sensitivity and motility of the patients' duodenum and stomach, leading to an inflammatory response in the gastrointestinal tract and gastric mucosa, which causes dyspepsia [4]. According to the Rome III guidelines, patients with dyspepsia must additionally exhibit one or more of the following symptoms: postprandial fullness, early satiation, epigastralgia, or epigastric burning.…”
Helicobacter pylori, sometimes known as H. pylori, is the most prevalent bacterium worldwide; it colonizes the stomachs of people on the planet, and the incidence of the disease is 85–90% in underdeveloped nations. The pathogenicity of bacteria varies according to the type of strain and the virulence factors it carries, such as the cytotoxin-related gene cagA, in addition to risk factors related to the host and environment. Due to the absence of data about the seroprevalence of antibodies to H. pylori in patients with dyspepsia in Libya in general and in the south in particular, the study aimed to assess the prevalence of H. pylori infection and its risk factors in Brack Al-Shati which is located in the Southwest of Libya. The study included 100 serum samples from dyspeptic patients whose ages varied in age from 18 to 72, with an average of 37.27 ± 1.515. All samples were examined using enzyme-linked immunosorbent assays (ELISA) to detect the presence of IgG antibodies against the CagA protein and H. pylori of the bacteria. The findings indicated that the rate of infection with H.pylori was 73% of the total patient samples, and 68.2% of the samples were positive for the CagA protein. Taking into account the frequency of CagA-positive strains and the seroprevalence of H. pylori in dyspeptic patients, we recommend paying attention to eradicating the bacteria through treatment, especially when more than one risk factor is present.
“…The majority of H. pylori-infected individuals experience persistently active gastritis that linked to Helicobacter pylori. In addition, changes in hormone secretion and gastric acid affect the sensitivity and motility of the patients' duodenum and stomach, leading to an inflammatory response in the gastrointestinal tract and gastric mucosa, which causes dyspepsia [4]. According to the Rome III guidelines, patients with dyspepsia must additionally exhibit one or more of the following symptoms: postprandial fullness, early satiation, epigastralgia, or epigastric burning.…”
Helicobacter pylori, sometimes known as H. pylori, is the most prevalent bacterium worldwide; it colonizes the stomachs of people on the planet, and the incidence of the disease is 85–90% in underdeveloped nations. The pathogenicity of bacteria varies according to the type of strain and the virulence factors it carries, such as the cytotoxin-related gene cagA, in addition to risk factors related to the host and environment. Due to the absence of data about the seroprevalence of antibodies to H. pylori in patients with dyspepsia in Libya in general and in the south in particular, the study aimed to assess the prevalence of H. pylori infection and its risk factors in Brack Al-Shati which is located in the Southwest of Libya. The study included 100 serum samples from dyspeptic patients whose ages varied in age from 18 to 72, with an average of 37.27 ± 1.515. All samples were examined using enzyme-linked immunosorbent assays (ELISA) to detect the presence of IgG antibodies against the CagA protein and H. pylori of the bacteria. The findings indicated that the rate of infection with H.pylori was 73% of the total patient samples, and 68.2% of the samples were positive for the CagA protein. Taking into account the frequency of CagA-positive strains and the seroprevalence of H. pylori in dyspeptic patients, we recommend paying attention to eradicating the bacteria through treatment, especially when more than one risk factor is present.
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