Basic technique and anatomically imposed limitations of confocal scanning laser Doppler flowmetry at the optic nerve head level

Sehi, Mitra

doi:10.1111/j.1755-3768.2009.01728.x

Cited by 17 publications

(10 citation statements)

References 78 publications

(101 reference statements)

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“…Previous studies demonstrated reduced ocular vascularization in glaucomatous eyes in the ophthalmic, retinal, choroidal, and retrobulbar circulation [2,3]. Many studies investigated the ocular blood flow using methods such as fluorescein angiography [4], Heidelberg retina flowmeter which combines the principles of scanning laser Doppler flowmetry and confocal scanning laser techniques [5], and color Doppler imaging [6]. However, the clinical application of these methods was limited by the invasiveness of some of them, the lack of quantitative measures and the inability to visualize the microvasculature.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Ability and Discriminant Values of OCT-Angiography Parameters in Early Glaucoma Diagnosis

et al. 2018

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Purpose: To evaluate papillary, peripapillary, and macular vasculature with optical coherence tomography angiography in preperimetric (PPG), primary open-angle glaucoma (POAG), and normal eyes, and to assess diagnostic ability and associations among the vasculature and structural damage. Methods: This was an observational, cross-sectional study. Retinal nerve fiber layer (RNFL), ganglion cell complex thickness, whole-image (wiVD), inside disc (idVD), peripapillary (ppVD), and macular vessel densities were obtained. Analysis of variance, post hoc test, and Pearson coefficient were used. The areas under the receiver operating characteristic curve (AUC) and cut-offs were calculated. Results: Thirteen healthy, 39 PPG, and 19 POAG eyes were included. Papillary and peripapillary VD were lower in POAG eyes in all parameters analyzed. wiVD in PPG eyes (52.37 ± 5.04%) was significantly decreased compared to healthy eyes (58.02 ± 2.02%, p < 0.05). AUC ranged from 0.62 to 0.90; the established cut-off values were 56% for wiVD, 55% for idVD, and 62% for ppVD. Pearson’s correlation coefficient showed a direct correlation between the papillary or peripapillary VD and RNFL thickness. Conclusions: Vessel densities in POAG eyes are significantly lower than in healthy eyes, and they show good discriminatory abilities. A diminished microvascular network is associated with RNFL thinning more strongly in POAG than in PPG eyes.

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Section: Introductionmentioning

confidence: 99%

Diagnostic Ability and Discriminant Values of OCT-Angiography Parameters in Early Glaucoma Diagnosis

et al. 2018

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“…The artery branches into radial arterioles and smaller vessels on the vitreal surface of the retina. 2 Blood is returned through radial venules on the retinal surface that empty into the central retinal vein in the optic nerve. The total blood flow supplied to the choroid is much greater than that supplied to the retina.…”

Section: Anatomical Aspectsmentioning

confidence: 99%

“…The pial vessels obtain their supply either directly from the ophthalmic artery (OA) or indirectly from the recurrent branches from the SPCAs. 2 …”

Section: Anatomical Aspectsmentioning

confidence: 99%

“…One of the studies concluded that the vascular resistance of the OA could be associated with the development of visual field defects in NTG patients vis-a-vis patients with POAG. 2 Another study evaluated the blood flow in patients with POAG and NTG and reported that the blood flows in the OA, central retinal artery, and PCAs 11 were reduced in both forms of glaucoma, compared with controls.…”

Section: Ocular Blood Flow In Primary Open Angle Glaucoma and Normal mentioning

confidence: 99%

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Current Imaging Modalities for assessing Ocular Blood Flow in Glaucoma

Ichhpujani¹,

Mohindroo²

2016

Journal of Current Glaucoma Practice

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Glaucoma may be caused by an interplay of elevated intraocular pressure (IOP), vascular, genetic, anatomical, brain, and immune factors. The direct assessment of ocular hemodynam-ics offers promise for glaucoma detection, differentiation, and possibly new treatment modalities. All the methods currently in use to measure ocular blood flow have inherent limitations and measure different aspects of ocular blood flow. This review article attempts to provide detailed information on ocular perfu-sion pressure as well as an overview of the newly developed imaging technologies used to investigate ocular blood flow in glaucoma patients.How to cite this articleMohindroo C, Ichhpujani P, Kumar S. Current Imaging Modalities for assessing Ocular Blood Flow in Glaucoma. J Curr Glaucoma Pract 2016;10(3):104-112.

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“…The main limitation of this technique is that velocity and volume are measured in arbitrary units, making the comparison between CSLDF measurements and other technologies quite difficult. (54, 109) Nevertheless, CSLDF measurements could be used to compare relative changes in the ocular microcirculation occurring in patients at different stages of OAG progression with the predictions of mathematical models describing ocular hemodynamics; this comparison would help identify which structural, vascular and systemic factors would cause those changes.…”

Section: Techniques For Non-invasive Ocular Measurementsmentioning

confidence: 99%

Mathematical modeling approaches in the study of glaucoma disparities among people of African and European descents

Guidoboni¹,

Harris²,

Arciero³

et al. 2013

j coupled syst multiscale dyn

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Open angle glaucoma (OAG) is a severe ocular disease characterized by progressive and irreversible vision loss. While elevated intraocular pressure (IOP) is a well-established risk factor for OAG, the progression of OAG in many cases, despite IOP treatment, suggests that other risk factors must play significant roles in the development of the disease. For example, various structural properties of the eye, ocular blood flow properties, and systemic conditions have been identified as risk factors for OAG. Ethnicity has also been indicated as a relevant factor that affects the incidence and prevalence of OAG; in fact, OAG is the leading cause of blindness among people of African descent. Numerous clinical studies have been designed to examine the possible correlation and causation between OAG and these factors; however, these studies are met with the challenge of isolating the individual role of multiple interconnected factors. Over the last decade, various mathematical modeling approaches have been implemented in combination with clinical studies in order to provide a mechanical and hemodynamical description of the eye in relation to the entire human body and to assess the contribution of single risk factors to the development of OAG. This review provides a summary of the clinical evidence of ocular structural differences, ocular vascular differences and systemic vascular differences among people of African and European descent, describes the mathematical approaches that have been proposed to study ocular mechanics and hemodynamics while discussing how they could be used to investigate the relevance to OAG of racial disparities, and outlines possible new directions of research.

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Basic technique and anatomically imposed limitations of confocal scanning laser Doppler flowmetry at the optic nerve head level

Cited by 17 publications

References 78 publications

Diagnostic Ability and Discriminant Values of OCT-Angiography Parameters in Early Glaucoma Diagnosis

Diagnostic Ability and Discriminant Values of OCT-Angiography Parameters in Early Glaucoma Diagnosis

Current Imaging Modalities for assessing Ocular Blood Flow in Glaucoma

Mathematical modeling approaches in the study of glaucoma disparities among people of African and European descents

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