Basic study of a diagnostic modality employing a new electrical impedance tomography (EIT) method for noninvasive measurement in localized tissues

Abstract

The objective of this study is to develop a device for noninvasive local tissue electrical impedance tomography (EIT) using divided electrodes with guard electrodes and to validate its effectiveness using bioequivalent phantoms. For this purpose, we prepared a measurement device and bioequivalent phantoms, measured the electrical characteristics of the phantoms, and validated the method using the phantoms. Monolayer phantoms mimicking the brain and muscle and bilayer phantoms consisting of muscle and brain layers were prepared. The relative differences between the measured electrical conductivities of the monolayer brain and muscle phantoms and the true values determined by the 4-electrode method were both less than 10%. The relative differences between the measured and true values in the bilayer phantoms were less than 20% in both layers. The biological impedance measurement device that we developed was confirmed to be effective for impedance measurement in bilayer phantoms with different electrical impedances. To develop a device for the early diagnosis of breast diseases, the development of a multi-layer phantom and demonstration of the effectiveness of the device for its examination are necessary. If the device that we developed makes impedance measurement in breast tumors possible, it may be used as a new diagnostic modality for breast diseases.

The Effect of Gold Nanoparticle on Electrical Impedance of Tissue on Low Frequency Ranges

“…Different methods are used to measure electrical impedance of biological tissues. 4-electrode method is a standard and reliable method which is used in some research studies as a gold standard for the measurement [23]. This method as shown in Figure 1, was used to determine the electrical impedance.…”

“…EIT signal on frequencies between 10 Hz and 10 kHz is more sensitive to cellular structure tissues than frequencies above 10 kHz [22]. From literature, the 4-electrode method is a standard and comfortable method for the impedance measurement [23].…”