Basic Study for Size Estimation of Red Blood Cell Aggregates by Analyzing Ultrasonic Backscattering Properties Considering Ultrasonic Propagation Attenuation

Estimation of red blood cell aggregation size using power spectrum considering density of red blood cells in focal region

“…We have studied a noninvasive and quantitative method for measuring the RBC aggregate size using a high-frequency focused ultrasound transducer. [26][27][28][29][30][31] Fukushima et al assumed that aggregated RBCs are single-sphere scatterers and estimated their size from the scattering characteristics by normalizing the power spectrum measured from the vessel lumen by that from the posterior wall of the blood vessel as a reflector. [26][27][28][29] However, the vessel wall could have exhibited a slope to the probe surface and roughness on the surface.…”

“…[26][27][28][29][30][31] Fukushima et al assumed that aggregated RBCs are single-sphere scatterers and estimated their size from the scattering characteristics by normalizing the power spectrum measured from the vessel lumen by that from the posterior wall of the blood vessel as a reflector. [26][27][28][29] However, the vessel wall could have exhibited a slope to the probe surface and roughness on the surface. The reflection characteristics at the posterior wall might have a frequency dependence, which caused errors in the size estimation results, because a high-frequency ultrasound around 30 MHz was used.…”

Estimation of aggregate size of red blood cell by introducing reference power spectrum measured for hemispherical ultrafine wire

“…We have studied a noninvasive and quantitative method for measuring blood properties. [28][29][30][31][32][33][34][35][36][37] Saito et al assumed that RBCs aggregate as a single-sphere scatterer and estimated the size from the scattering characteristics extracted by normalizing the power spectrum measured from the vessel lumen with that from the rear wall using a focused ultrasound transducer. [28][29][30][31][32] We also examined the relationship between RBC aggregation using ultrasound and blood glucose level.…”

“…[28][29][30][31][32][33][34][35][36][37] Saito et al assumed that RBCs aggregate as a single-sphere scatterer and estimated the size from the scattering characteristics extracted by normalizing the power spectrum measured from the vessel lumen with that from the rear wall using a focused ultrasound transducer. [28][29][30][31][32] We also examined the relationship between RBC aggregation using ultrasound and blood glucose level. Sakaki et al compared the blood glucose levels with the parameters determined from changes in the scattering power spectra of the echoes from the vascular lumen before and after avascularization.…”