Basic studies on a labeled anti-mucin antibody detectable by infrared-fluorescence endoscopy

Bando, Terumi; Muguruma, Naoki; Ito, Susumu; Musashi, Yoko; Inayama, Kumi; Kusaka, Yoshiaki; Tadatsu, Masaya; Kunio,; Irimura, Tatsuro; Shibamura, Seiichi; Takesako, Kazuhiro

doi:10.1007/s005350200033

Cited by 25 publications

(18 citation statements)

References 28 publications

(51 reference statements)

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“…Mucin, a glycoprotein containing a large amount of sugar, is the main component of mucus, and the peptide structure of the mucin core protein has been determined. The specific expression of mucin in various digestive tract cancers has been studied 30. Based on the ability to measure it with a relatively high sensitivity, mucin is a useful biomarker that should be targeted.…”

Section: Target Biomarkersmentioning

confidence: 99%

Endoscopic Molecular Imaging: Status and Future Perspective

et al. 2013

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During the last decade, researchers have made great progress in the development of new image processing technologies for gastrointestinal endoscopy. However, diagnosis using conventional endoscopy with white light optical imaging is essentially limited, and ultimately, we still rely on the histopathological diagnosis from biopsy specimens. Molecular imaging represents the most novel imaging methods in medicine, and the future of endoscopic diagnosis is likely to be impacted by a combination of biomarkers and technology. Endoscopic molecular imaging can be defined as the visualization of molecular characteristics with endoscopy. These innovations will allow us not only to locate a tumor or dysplastic lesion but also to visualize its molecular characteristics and the activity of specific molecules and biological processes that affect tumor behavior and/or its response to therapy. In the near future, these promising technologies will play a central role in endoluminal oncology.

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Section: Target Biomarkersmentioning

confidence: 99%

Endoscopic Molecular Imaging: Status and Future Perspective

et al. 2013

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“…Reactive derivatives of ICG including ICG- N -hydroxysulfosuccinimide ester (ICG-sulfo-OSu) and 3-ICG-acyl-1,3-thiazolidine-2-thione (ICG-ATT) have been developed and labeled with anti-CEA and anti-MUC1. These conjugated compounds exhibit small shifts in the excitation and emission wavelengths relative to pure ICG, and have been used to demonstrate the proof of principle for targeted endoscopic imaging [73]. Furthermore, monoclonal ICG-labeled mouse anti-CEA antibody has been used to target gastric cancer on biopsy specimens and imaged with NIR endoscopy.…”

Section: Molecular Probes For Optical Imagingmentioning

confidence: 99%

Exogenous Molecular Probes for Targeted Imaging in Cancer: Focus on Multi-modal Imaging

Joshi

Wang

2010

Cancers

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Cancer is one of the major causes of mortality and morbidity in our health care system. Molecular imaging is an emerging methodology for the early detection of cancer, and the development of exogenous molecular probes that can be labeled for multi-modality imaging is critical to this process. Today, molecular imaging is at crossroad, and new targeted imaging agents are expected to broadly expand our ability to detect pre-malignant lesions. This integrated imaging strategy will permit clinicians to not only localize lesions within the body, but also to visualize the expression and activity of specific molecules. This information is expected to have a major impact on diagnosis, therapy, drug development and understanding of basic cancer biology. At this time, a number of molecular probes have been developed by conjugating various labels to affinity ligands for targeting in different imaging modalities. This review will describe the current status of exogenous molecular probes for optical, nuclear and MRI imaging platforms. Furthermore, we will also shed light on how these techniques can be used synergistically in multi-modal platforms and how these techniques are being employed in current research.

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“…Mucin, a glycoprotein containing a large amount of sugar, is the main component of mucus, and the peptide structure of the mucin core protein has been clarified (Kim, 1993). The specific expression of mucin in various cancers has been reported, and we also studied the staining pattern and evaluated its sensitivity in gastrointestinal cancers (Bando et al, 2002). Based on its relatively high sensitivity (Nakamori, 1994), we labeled an anti-MUC1 antibody (MY.1E12; kindly provided by Prof. Tatsuro Irimura, The University of Tokyo) with ICG-ATT.…”

Section: Labeled Antibodiesmentioning

confidence: 99%