Basic Self-Disturbance Predicts Psychosis Onset in the Ultra High Risk for Psychosis (“Prodromal”) Population

Nelson, Barnaby; Thompson, Andrew; Yung, Alison R.

doi:10.1016/s0920-9964(12)70144-5

Cited by 57 publications

(94 citation statements)

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“…14,15 SDs are detectable in populations at high-genetic risk for schizophrenia 13 and are associated with prodromal symptoms among help-seeking, non-psychotic adolescents. 16 SDs predict psychosis in clinically at-risk prodromal populations 17 as well as new cases of schizophreniaspectrum disorders in a follow up of non-spectrum psychiatric patients 5 years after first admission. 18 SDs affect the 'core' or 'minimal' experiential self, [19][20][21] that is, a structure that must be in place in order for the experience to be subjective, that is, to be someone's experience.…”

Section: Introductionmentioning

confidence: 99%

“…24 The EASE possesses good to excellent interrater reliability among trained interviewers. 17,25,26 It consists of 57 main items and explores five overlapping domains of experience: (i) stream of consciousness (experience of cognition and emotion); (ii) sense of presence/basic identity; (iii) bodily experience; (iv) sense of demarcation ('ego boundaries'); and (v) existential reorientation (e.g. finding a new life meaning) and solipsistic experiences.…”

Section: Introductionmentioning

confidence: 99%

“…The EASE exhibits high internal consistency (Cronbach's alpha above 0.80 11,14 ) and a monofactorial structure. 11,27 Although all studies seem to support the notion of SDs as a spectrum-specific manifestation of vulnerability, and follow-up studies of help-seeking, prodromal and first-admission patients have shown the utility of SDs for predicting later spectrum disturbance, 17,18 there have been as yet no attempts to identify SDs and gauge their predictive value in a premorbid, not-help-seeking population at high risk for schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

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Premorbid self‐disorders and lifetime diagnosis in the schizophrenia spectrum: a prospective high‐risk study

Parnas

Carter

Nordgaard

2014

Early Intervention Psych

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Aim: The notion of a disordered self as a core disturbance of schizophrenia was proposed in many foundational texts. Recent studies, spurred by the development of the Examination of Anomalous Self-Experience (EASE), seem to indicate that selfdisorders are a specific manifestation of schizophrenia vulnerability. Follow-up studies of help-seeking, prodromal and first-admission patients have demonstrated the utility of self-disorders for predicting later schizophrenia-spectrum disturbance. We wished to extend these findings by gauging the predictive value of self-disorders in a premorbid, non-clinical population at high risk for schizophrenia. Methods:Children from the Copenhagen High-Risk Project with highgenetic risk for schizophrenia (N = 212) were assessed premorbidly (average age = 15), and diagnostically re-evaluated after 10 and 25 years. Since the EASE was not available at the time of premorbid assessment, we hypothesized that a proxy scale drawn from the Minnesota Multiphasic Personality Inventory (MMPI) could distinguish those who later developed a schizophrenia-spectrum disorder (N = 68) from those who remained healthy (N = 64). The Self-Disorder Scale comprised 32 items whose content suggested an aspect of selfdisorder as measured by the EASE.Results: Premorbid Self-Disorder Scale scores significantly predicted lifetime schizophrenia-spectrum diagnosis in the high-risk cohort. Although there was considerable item overlap between the new scale and an existing MMPI scale (psychoticism), the overlap did not account for the Self-Disorder Scale's predictive efficacy. Conclusion:The results support the notion of self-disorders as a core vulnerability feature in schizophrenia, detectable premorbidly in those developing later schizophreniaspectrum disorders.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Premorbid self‐disorders and lifetime diagnosis in the schizophrenia spectrum: a prospective high‐risk study

Parnas

Carter

Nordgaard

2014

Early Intervention Psych

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“…SF ser også ut til å ha klar sammenheng med suicidalitet ved schizofreni (468). Nye funn indikerer at SF også kan predikere overgang til psykose i UHrgruppen (469). Manualen EASE, Examination of Anomalous SelfExperience (470) er utviklet for å undersøke disse forstyrrelsene systematisk, og har vist gode psykometriske egenskaper (471;472).…”

Section: «Varselfasen» (Prodromalfasen)unclassified

Psykisk syke mangler rettssikkerhet

Thowsen¹,

Overrein²

2017

Tidsskriftet

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“…Follow-up studies of help-seeking, prodromal, and first-admission patients have shown that the presence of SDs predicts a subsequent schizophrenia spectrum diagnosis (18,19). One study examined a non-clinical population at high risk for schizophrenia and found that premorbid SDs significantly predicted lifetime schizophrenia spectrum diagnoses (20).…”

mentioning

confidence: 99%