Basic self-disorders in adolescence predict schizophrenia spectrum disorders in young adulthood: A 7-year follow-up study among non-psychotic help-seeking adolescents

Koren, Danny; Tzivoni, Yair; Schalit, Liat; Adres, Merav; Reznik, Noa; Apter, Alan; Parnas, Josef

doi:10.1016/j.schres.2019.12.022

Cited by 36 publications

(23 citation statements)

References 34 publications

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“…Higher scores are obtained in people with positive schizotypy compared to negative schizotypy as well as in patients with schizophrenia compared with healthy controls [1]. A prospective study on non-clinical help-seeking adolescents has shown that ASEs can serve as a clinical marker of risk for schizophrenia-spectrum disorder [7]. Another study on non-psychotic young adults has shown that a combination of high level of PLEs and self-disturbances may capture the highest risk of psychosis in the general population associated with cognitive biases characteristic for psychosis [9].…”

Section: Introductionmentioning

confidence: 99%

Effects of interactions between variation in dopaminergic genes, traumatic life events, and anomalous self-experiences on psychosis proneness: Results from a cross-sectional study in a nonclinical sample

et al. 2020

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Section: Introductionmentioning

confidence: 99%

Effects of interactions between variation in dopaminergic genes, traumatic life events, and anomalous self-experiences on psychosis proneness: Results from a cross-sectional study in a nonclinical sample

et al. 2020

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“…Our findings seem to converge around central phenomena of schizophrenia spectrum disorders, including selfdisorder. From our own and others' studies, we know that selfdisorder constitutes a trait phenomenon that is present before the full symptomatology of schizophrenia manifests (40)(41)(42)(43)(44), suggesting that self-disorder constitutes a basic framework within which the heterogeneous symptoms associated with schizophrenia may be unified and to some extent understood.…”

Section: Discussionmentioning

confidence: 98%

Formal Thought Disorder and Self-Disorder: An Empirical Study

et al. 2021

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Background: Formal thought disorder was constitutively linked to the original concept of schizophrenia and has since been one of central features supporting its diagnosis. Bleuler considered formal thought disorder as a fundamental symptom of schizophrenia among other fundamental symptoms, including ego disorders. The contemporary concept of self-disorder represents a more developed, nuanced, and systematic approach to disturbances of self-experience than the Bleulerian concept of ego disorders. As fundamental symptoms, on Bleuler's account, are persistently present in every case, an association between these symptoms could be expected. The purpose of this study was to examine the association between self-disorder and formal thought disorder.Methods: A sample of 94 diagnostically heterogeneous patients was examined for formal thought disorder using clinical rating and a proverb test. The proverb test was analyzed for two different aspects of formal thought disorder: literal responses and bizarre responses. The sample was comprehensively assessed for psychopathology, including self-disorder as measured with the Examination of Anomalous Self-Experience scale.Results: The patients, who provided bizarre responses, had a higher level of self-disorder, more negative symptoms, lower level of social functioning, and lower level of intelligence. Bizarre answers aggregated in patients diagnosed within the schizophrenia spectrum compared with patients outside the schizophrenia spectrum. We found moderate correlations between the two measures of formal thought disorder (clinically rated and bizarre responses) and self-disorder (0.454 [p < 0.01] and 0.328 [p < 0.01]). Literal responses did not differ between diagnostic groups and also did not correlate with bizarre responses. Specificity of bizarre responses for a diagnosis within schizophrenia spectrum was 86.89%, whereas sensitivity was 40.85%.Conclusion: The close relation between formal thought disorder and self-disorder further adds to the notion of self-disorder as a unifying psychopathological core beneath the apparently heterogeneous symptoms of schizophrenia.

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“…None of the patients sought help because of their hoarding but for other reasons. Anomalous self-experiences have been shown specifically among patients with schizophrenia [24], and they are present long before the patients are diagnosed with their primary illness [25][26][27][28]. This is a possible explanation for the early onset of hoarding.…”

Section: Discussionmentioning

confidence: 99%

The Hoarding Phenomenon in Schizophrenia Spectrum Disorders

2020

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The presence of hoarding behavior among patients with schizophrenia has been known for more than a century. Nevertheless, only a few studies have examined the hoarding phenomenon among patients with schizophrenia, and no studies have examined the potential motivation. Hoarding disorder became a separate diagnosis in DSM-5. Studies about hoarding disorder use primarily quantitative approaches (e.g., scales, self-administered questionnaires, and structured interviews) when assessing the patients. The main objectives of this study were to examine the meaning of hoarding for patients with schizophrenia spectrum disorders and to explore associated psychopathology which may motivate the hoarding. We have examined 13 patients diagnosed with schizophrenia spectrum disorders showing hoarding behavior. The patients underwent semistructured, narrative interviews about the following domains: the time of onset of hoarding, the meaning of hoarding and associated psychopathology, the presence of insight into hoarding, and problematic issues about discarding. The study shows that hoarding begins very early in life for these patients and can be motivated by various psychopathologies. Diminished sense of basic self and transitivistic experiences were mentioned by several patients as motivations for collecting objects. Furthermore, the difficulty with discarding reflected a huge ambivalence and ruminations. Our findings suggest that thorough and comprehensive assessments of people with hoarding symptoms are necessary to assure the correct diagnosis and to understand the patient. An increased knowledge of the patients' motivations for hoarding behavior may also be useful for the treating personnel and may prevent social adversities. We think it is questionable that in the DSM-5 hoarding is not mentioned in the description of schizophrenia but has been elevated to a separate disorder.

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Basic self-disorders in adolescence predict schizophrenia spectrum disorders in young adulthood: A 7-year follow-up study among non-psychotic help-seeking adolescents

Cited by 36 publications

References 34 publications

Effects of interactions between variation in dopaminergic genes, traumatic life events, and anomalous self-experiences on psychosis proneness: Results from a cross-sectional study in a nonclinical sample

Effects of interactions between variation in dopaminergic genes, traumatic life events, and anomalous self-experiences on psychosis proneness: Results from a cross-sectional study in a nonclinical sample

Formal Thought Disorder and Self-Disorder: An Empirical Study

The Hoarding Phenomenon in Schizophrenia Spectrum Disorders

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