Basic science of cardiac contractility modulation therapy: Molecular and electrophysiological mechanisms

Masarone, Daniele; Kittleson, Michelle M.; D’Onofrio, Antonio; Falco, Luigi; Fumarulo, Isabella; Massetti, Massimo; Crea, Filippo; Aspromonte, Nadia; Pacileo, Giuseppe

doi:10.1016/j.hrthm.2023.09.021

Cited by 7 publications

(3 citation statements)

References 78 publications

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“…If the acute local changes can, therefore, be partly explained by the modulation of ion channels, the mechanisms by which CCM therapy modifies gene expression by inducing reverse remodeling remain to be fully elucidated [ 13 , 25 ].…”

Section: Ccm: Mechanisms Of Actionmentioning

confidence: 99%

Cardiac contractility modulation in patients with heart failure: The added value of cardiac rehabilitation in identification, management, and follow-up

Ruzzolini,

Giallauria,

Fattirolli

et al. 2024

International Journal of Cardiology Cardiovascular Risk and Pre

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Section: Ccm: Mechanisms Of Actionmentioning

confidence: 99%

Cardiac contractility modulation in patients with heart failure: The added value of cardiac rehabilitation in identification, management, and follow-up

Ruzzolini,

Giallauria,

Fattirolli

et al. 2024

International Journal of Cardiology Cardiovascular Risk and Pre

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“…Furthermore, CCM can contribute to the positive remodeling of the myocardium, reverse the maladaptive fetal gene program, and help reduce cardiac fibrosis. [99] The first clinical trial to study the effects of CCM was the FIX-HF-4, which employed a double-blind, randomized, crossover design modelled after the MUSTIC trial of CRT. In this study, 164 HFrEF patients were selected.…”

Section: Cardiac Contractility Modulationmentioning

confidence: 99%

Beyond Medical Therapy—An Update on Heart Failure Devices

Falco,

Valente,

De Falco

et al. 2024

JCDD

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Heart failure (HF) is a complex and progressive disease marked by substantial morbidity and mortality rates, frequent episodes of decompensation, and a reduced quality of life (QoL), with severe financial burden on healthcare systems. In recent years, several large-scale randomized clinical trials (RCTs) have widely expanded the therapeutic armamentarium, underlining additional benefits and the feasibility of rapid titration regimens. This notwithstanding, mortality is not declining, and hospitalizations are constantly increasing. It is widely acknowledged that even with guideline-directed medical therapy (GDMT) on board, HF patients have a prohibitive residual risk, which highlights the need for innovative treatment options. In this scenario, groundbreaking devices targeting valvular, structural, and autonomic abnormalities have become crucial tools in HF management. This has led to a full-fledged translational boost with several novel devices in development. Thus, the aim of this review is to provide an update on both approved and investigated devices.

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“…As the autonomic tone is impaired and dysregulated in heart failure patients, Cardiac Contractility Modulation (CCM) therapy emerged as another tool in the armamentarium, particularly in patients who remain symptomatic despite optimal medical therapy. This non-excitatory electrical therapy delivers signals to the heart during the absolute refractory period, enhancing myocardial contractility without increasing heart rate (8).…”

mentioning

confidence: 99%

Editorial: Electrical management of heart failure: shaping the future of cardiac pacing and electrophysiology

Bressi,

Luermans,

Arnold

et al. 2023

Front. Cardiovasc. Med.

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Basic science of cardiac contractility modulation therapy: Molecular and electrophysiological mechanisms

Cited by 7 publications

References 78 publications

Cardiac contractility modulation in patients with heart failure: The added value of cardiac rehabilitation in identification, management, and follow-up

Cardiac contractility modulation in patients with heart failure: The added value of cardiac rehabilitation in identification, management, and follow-up

Beyond Medical Therapy—An Update on Heart Failure Devices

Editorial: Electrical management of heart failure: shaping the future of cardiac pacing and electrophysiology

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