Basic properties of calcium phosphate cement containing atelocollagen in its liquid or powder phases

Calcium orthophosphate-based biocomposites and hybrid biomaterials

“…CDHA crystals were found to nucleate on the collagen fibril network, giving a material with the mechanical properties weaker than those reported for bone. More to the point, these biocomposites were without the nanostructure similar to that of bone [599,623]. The oriented growth of OCP crystals on collagen was achieved by an experimental device in which Ca 2?…”

“…Besides, collagen might be incorporated into calcium orthophosphate cements [599,623,634]. Typically, the type I collagen sponge is presoaked in PO 4 3--containing a highly basic aqueous solution and then is immersed into a Ca 2?…”

Biocomposites and hybrid biomaterials based on calcium orthophosphates

“…Even more significantly, the prepared biocomposites were without a nanostructure similar to that of bone. 713,738 The oriented growth of OCP crystals on collagen was achieved by an experimental device in which Ca 2+ and PO 4 3-ions diffused into a collagen disc from the opposite directions. 737,739,740 Unfortunately, these experiments were designed to simulate the mechanism of in vivo precipitation of biological apatite only; for this reason, the mechanical properties of the biocomposites were not tested.…”

Effects of added mannitol on the setting reaction and mechanical strength of apatite cement

“…Therefore, a concern studies [25][26][27] and the present study was the medium to arose over the inhibitory effect of mannitol on the which the organic materials were added. In previous [25][26][27] , organic materials such as collagen and sodium alginate were added to the liquid phase in order to increase the handling time or to acquire antiwashout property. When organic materials were added to the liquid phase and mixed with the powder phase, the entire surface of the powder particles would be exposed to the organic materials.…”

“…1 and 2). addition of organic materials, although the apatite As for organic materials, they are known to inhibit cements used were not Biopex ® [25][26][27] . crystal nucleation and crystal growth when adsorbed One of the key differences between the previous onto the growing crystal surface.…”