Basic organization of projections from the oval and fusiform nuclei of the bed nuclei of the stria terminalis in adult rat brain

Dong, Hong‐Wei; Petrovich, Gorica D.; Watts, Alan G.; Swanson, Larry W.

doi:10.1002/cne.1079

Cited by 451 publications

(529 citation statements)

References 145 publications

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“…See Table 1 for brain region abbreviations. other brain regions, including the DG, LH, VL, CPu and PrL, was altered. The BNST has afferent and efferent connections with several regions, including the amygdala, LH, PAG and the PFC [40][41][42] , and neural activity of BNST could partly contribute to increased MEMRI signal in these areas through axonal transport. However, out of these established connections we only observed significant correlation of BNST activation with the LH and the PrL following CSDS.…”

Section: Discussionmentioning

confidence: 99%

Brain activation induced by chronic psychosocial stress in mice

Laine

Sokołowska

Dudek

et al. 2017

European Neuropsychopharmacology

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Chronic psychosocial stress is a well-established risk factor for neuropsychiatric diseases. Abnormalities in brain activity have been demonstrated in patients with stress-related disorders. Global brain activation patterns during chronic stress exposure are less well understood but may have strong modifying effects on specific brain circuits and thereby influence development of stress-related pathologies. We determined neural activation induced by chronic social defeat stress, a mouse model of psychosocial stress. To assess chronic activation with an unbiased brain-wide focus we used manganese-enhanced magnetic resonance imaging (MEMRI) and immunohistochemical staining of ∆FOSB, a transcription factor induced by repeated neural activity. One week after 10-day social defeat we observed significantly more activation in several brain regions known to regulate depressive and anxiety-like behaviour, including the prefrontal cortex, bed nucleus of stria terminalis, ventral hippocampus and periaqueductal grey in stressed compared to control mice. We further established that the correlation of ∆FOSB positive cells between specific brain regions was altered following chronic social defeat. Chronic activation of these neural circuits may relate to persistent brain activity changes occurring during chronic psychosocial stress exposure, with potential relevance for the development of anxiety and depression in humans.Psychosocial stress increases the risk for both somatic and psychiatric diseases and worsens their prognosis 1-4 . This term refers to a broad range of experiences, including lack of normative care, abuse, and problems in peer relationships such as bullying 5 . Stress-related mental disorders like major depressive disorder (MDD) and anxiety disorders are associated with altered activation of specific brain regions. For example, neuroimaging has revealed that resting-state activity is reduced in the prefrontal cortex (PFC) 6 and increased in the hippocampus 7 while task-related reactivity is decreased in the hippocampus 8 and nucleus accumbens 9 of MDD patients. Interpretation of the human imaging findings is difficult as activation patterns in tasks carried out during brain imaging may differ from those occurring during naturalistic chronic stress exposure. Because patients enrolled in these studies also tend to have an extensive history of symptoms and medication use, it is challenging to reveal direct consequences of chronic psychosocial stress itself. In contrast, animal models allow investigation of specific stressors in a controlled manner to establish the mechanisms connecting chronic psychosocial stress exposure, brain activation, and subsequent emotional and social behaviour.Chronic social defeat stress (CSDS) is a rodent model of psychosocial stress, which produces many behavioural features similar to the symptoms of human anxiety and mood disorders, such as social aversion, anhedonia (decreased sucrose-preference) and increased self-administration of drugs of abuse 10,11 . These behavioural phenotypes...

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Section: Discussionmentioning

confidence: 99%

Brain activation induced by chronic psychosocial stress in mice

Laine

Sokołowska

Dudek

et al. 2017

European Neuropsychopharmacology

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“…The BST is ideally located anatomically and functionally to receive incoming noxious information, process this information along with additional incoming neocortical (prefrontal cortex) and other limbic structure (amygdala, hippocampus) information, and relay this message to the periphery (midbrain and brainstem) (Dong et al, 2000;Dong et al, 2001a;Dong et al, 2001b;Dong and Swanson, 2003, 2004a, b, 2006a). …”

Section: Discussionmentioning

confidence: 99%

“…Similarly, the FU projects along approximately 4 distinct pathways that terminate in the central amygdala, hypothalamus (PVH), midbrain (ventral tegmental area) and lower brainstem (lateral periaque-ducal gray, raphe) (Dong et al, 2001b). Each of these descending pathways corresponds to important physiological functions triggered by nociceptive stimuli such as defensive behaviours, descending analgesia, autonomic control of breathings, cardiovascular responses, arousal, and activation of HPA axis (Choi et al, 2007;Dick and Coles, 2000;Rossi et al, 1994;Satoh and Fibiger, 1986;Vertes, 1991).…”

Section: Significance Of Noxious Stimulation-induced Neuronal Activatmentioning

confidence: 99%

Nuclei-and condition-specific responses to pain in the bed nucleus of the stria terminalis

Morano

Bailey

Cahill

et al. 2008

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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The bed nucleus of the stria terminalis (BST) is a basal forebrain structure considered to be part of a cortico-striato-pallidal system that coordinates autonomic, neuroendocrine and behavioural physiological responses.Recent evidence suggests that the BST plays a role in the emotional aspect of pain. The objective of the present study was to further understand the neurophysiological bases underlying the involvement of the BST in the pain experience, in both acute and chronic pain conditions. Using c-Fos as an indicator of neuronal activation, the results demonstrated that a single toe-pinch in rats produced nuclei-and condition-specific neuronal responses within the anterior region of the BST (antBST). Specifically, acute noxious stimulation increased c-Fos in the dorsal medial (dAM) and fusiform (FU) nuclei. Chronic neuropathic pain induced by chronic constriction injury (CCI) of the sciatic nerve decreased the number of c-Fos positive cells following acute mechanical stimulation in the dAM and FU nuclei, and increased c-Fos immunoreactivity in the ventral medial (vAM) aspect of the BST. In addition, the results revealed a nuclei-specific sensitivity to the surgical procedure. Following noxious stimulation to animals that received a sham surgery, c-Fos immunoreactivity was blunted in the FU nucleus while it increased in the oval (OV) nucleus of the BST.Altogether, this study demonstrates that pain induces nuclei-and condition-specific neuronal activation in the BST revealing an intriguing supraspinal neurobiological substrate that may contribute to the physiology of acute nociception and the pathophysiology of chronic pain.

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“…Anatomical studies indicate that the hippocampus and amygdala mainly relay signals by heavily innervating PVN-projecting basal forebrain and hypothalamic structures. Notably, the bed nucleus of the stria terminalis (BST) is among the main extrahypothalamic regions that receives abundant input from all of the noted limbic regions (Cullinan et al, 1993;Dong et al, 2001b;Dong and Swanson, 2004;Gu et al, 2003;Sawchenko and Swanson, 1983).…”

Section: Introductionmentioning

confidence: 99%

The role of the posterior medial bed nucleus of the stria terminalis in modulating hypothalamic–pituitary–adrenocortical axis responsiveness to acute and chronic stress

Choi¹,

Furay²,

Evanson³

et al. 2008

Psychoneuroendocrinology

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SummaryThe bed nucleus of the stria terminalis (BST) plays a prominent role in brain integration of acute responses to stressful stimuli. This study tests the hypothesis that the BST plays a complementary role in regulation of physiological changes associated with chronic stress exposure. Male SpragueDawley rats received bilateral ibotenate lesions or sham lesions of the posterior medial region of the BST (BSTpm), an area known to be involved in inhibition of HPA axis responses to acute stress. Chronic stress was induced by 14-day exposure to twice daily stressors in an unpredictable sequence (chronic variable stress (CVS)). On the morning after the end of CVS, stressed and nonstressed controls were exposed to a novel restraint stress challenge. As previously documented, CVS caused adrenal hypertrophy, thymic involution, and attenuated body weight gain. None of these endpoints were affected by BSTpm lesions. Chronic stress exposure facilitated plasma corticosterone responses to the novel restraint stress and elevated CRH mRNA. Lesions of the BSTpm increased novel stressor-induced plasma ACTH and corticosterone secretion and enhanced c-fos mRNA induction in the paraventricular nucleus of the hypothalamus (PVN). In addition, lesion of the BSTpm resulted in an additive increase in CVS-induced facilitation of corticosterone responses and PVN CRH expression. Collectively these data confirm that the BSTpm inhibits HPA responses to acute stress, but do not strongly support an additional role for this region in limiting HPA axis responses to chronic drive. The data further suggest that acute vs. chronic stress integration are subserved by different brain circuitry.

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Basic organization of projections from the oval and fusiform nuclei of the bed nuclei of the stria terminalis in adult rat brain

Cited by 451 publications

References 145 publications

Brain activation induced by chronic psychosocial stress in mice

Brain activation induced by chronic psychosocial stress in mice

Nuclei-and condition-specific responses to pain in the bed nucleus of the stria terminalis

The role of the posterior medial bed nucleus of the stria terminalis in modulating hypothalamic–pituitary–adrenocortical axis responsiveness to acute and chronic stress

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