Basic ionic liquid, 2-hydroxyethylammonium formate, catalyzed one-pot synthesis of novel 2-(phenylsulfonyl)-1H-benzo[a]pyrano[2,3-c]phenazin-3-amine derivatives

[(EtO) 3 Si(CH 2 ) 3 N + H 3 ][CH 3 COO - ] as basic ionic liquid catalyst promoted green synthesis of benzo[a]pyrano[2,3-c]phenazine derivatives

“…According to the literature catalyst [23], The proposed mechanism for product formation is shown in Reusability of the catalysts is important in green environmental chemistry. For this purpose, we studied, the reaction of 2-hydroxynaphthalene-1,4-dione (1 mmol) and benzene-1,2-diamine (1 mmol), benzaldehyde (1 mmol) and malononitrile (1 mmol) as a model under solvent-free conditions at 90 o C. After completion of reactions, ionic liquid as catalyst was soluble in EtOH and could be recovered and reused conveniently after removing ethanol under vacuum at 70°C for 2 h. The recovered catalyst was reused for at least ve runs without any loss of its activity (Fig.…”

“…In continuation of our research on the synthesis and applications of homogenous and heterogeneous catalysts in organic chemistry [22] [23], here, we use the [(EtO) 3 Si(CH 2 ) 3 N + H 3 ][CH 3 COO − ] as basic ionic liquid, and reusable catalyst for the one-pot synthesis of benzo[a]pyrano [2,3-c]phenazine derivatives by four-component condensation of 2-hydroxynaphthalene-1,4-dione, benzene-1,2-diamine, malononitrile and arylaldehydes at 90°C under solvent-free conditions (Scheme 1).…”

Synthesis of 2‐amino‐4H‐chromenes and spirochromenes using basic ionic liquid, 2‐hydroxyethylammonium formate as green, stable, and reusable catalyst

“…We believe that the ionic liquid of 2-hydroxyethylammonium formate plays an acid-base role, simultaneously. [23] In the first stage, Knoevenagel condensation of aryl aldehyde 3a and malononitrile 2 (both are activated by 2-hydroxyethylammonium formate) forms intermediate A. In the following, phloroglucinol 1 is activated by 2-hydroxyethylammonium formate and attacks Intermediate A and using the C-alkylation process forms Intermediate B.…”

“…The physical data of the obtained ionic liquid was compared with the authentic sample. [23] 3.3 | General Procedure for the synthesis of 2-amino-4H-chromenes and spirochromenes using ionic liquid [HO(CH 2 ) 2 NH 3 +…”

“…Also, the stretching of the carbonyl group and the vibrations of the N H plane bond in the composition of the ionic liquid can be seen as a combined bond centered around 1,600 cm À1 . [8,23]…”