Basic Fibroblast Growth Factor Levels in the Vitreous of Patients With Proliferative Diabetic Retinopathy

Sivalingam, Arunan; Kenney, John S.; Brown, Gary C.; Benson, William E.; Donoso, Larry A.

doi:10.1001/archopht.1990.01070080113046

Cited by 197 publications

(90 citation statements)

References 30 publications

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“…All data are expressed as per cent of control SEM; * indicates statistical significance (p < 0.05) compared with sham-treated control; + indicates statistical significance vs 2´20 mg/day; # indicates statistical significance compared with 2´50 mg/day dominant growth factor involved in the propagation of the neovascular response to ischaemia. Accordingly, despite the lack of a signal sequence, bFGF is increased in retinae with proliferative retinal diseases [24,25]. The temporal but distinct expression and distribution of both growth factors in the ROP model contradicts a direct relation between bFGF and VEGF induction.…”

Section: Discussionmentioning

confidence: 95%

Kinetics of integrin expression in the mouse model of proliferative retinopathy and success of secondary intervention with cyclic RGD peptides

et al. 2002

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Angiogenesis during adulthood is limited to a few tissue sites such as the ovary and the uterus (during reproduction) and the skin (during wound healing) [1,2]. However, despite the normal low turnover rate, adult endothelial cells are permanently able to form new blood vessels during pathologic angiogenesis which is involved in a variety of diseases such as tumor formation and metastasis, inflammatory skin and joint diseases [3], and in ocular diseases such as proliferative diabetic retinopathy [4]. These conditions require the transformation of the mature resting endothelial cell to an angiogenic endothelial pheno- Diabetologia (2002) Results. a v -integrin expression started immediately after induction of hypoxia (at postnatal day 12, p12) and persisted only during the initial period of neovascularization (until day p14). Vascular endothelial growth factor (VEGF) expression started at high values immediately after return of the mice into room air, and dropped rapidly to low values beyond day 13. In contrast, basic fibroblast growth factor (bFGF) was predominantly expressed during the phase of maximum angiogenesis which was noted between day p17 and 19. Based on these findings, cyclic penta peptide was administered subcutaneously at varying doses (2±20 mg/kg/day) for 5 days beginning either at day p14 (early intervention) or at day p17 (late intervention). Early secondary intervention showed a dose-dependent reduction of new vessels with maximum inhibition of 57 % (control 68.08 3.21 nuclei/section compared with RGDfVtreated 29.35 2.39 nuclei/section; p < 0.0001), whereas late secondary intervention had no effect. Conclusion/hypothesis. These data indicate that angiogenesis-related a v -integrin expression is VEGFrather than bFGF-dependent, and the efficacy of cyclic penta-peptid (RGDfV)-treatment in proliferative retinopathy is only effective as long as the a v -integrin target is prominently expressed. [Diabetologia (2002) 45: 262±267]

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Section: Discussionmentioning

confidence: 95%

Kinetics of integrin expression in the mouse model of proliferative retinopathy and success of secondary intervention with cyclic RGD peptides

et al. 2002

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“…TNF-α is the major cytokine produced by macrophages which are often present at the sites of active neovascularization (Penfold et al, 1984). In addition to TNF-α, various growth factors are produced at onset of ocular neovascularization and have been detected in vitreous (Sivalingam et al, 1990) and epiretinal membranes (Malecaze et al, 1994;Armstrong et al, 1998;Ambati et al, 1997). Human RPE cells are strongly immunoreactive for aFGF/bFGF and TGF-β in choroidal neovascular membranes of age-related macular degeneration (AMD), but not in normal human eyes (Amin et al, 1994).…”

Section: Discussionmentioning

confidence: 99%

Regulation of VEGF mRNA expression and protein secretion by TGF-β2 in human retinal pigment epithelial cells

Bian

Elner

2007

Experimental Eye Research

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“…Previous studies have demonstrated that the retinal degeneration in an animal model is partly rescued by several growth factors, including basic fibroblast growth factor (bFGF), presumably by inhibiting the apoptotic process. 1,2 However, these factors stimulate proliferation of fibroblast 3 and vascular endothelial cells, 4 and are involved in detrimental processes such as proliferative vitreoretinopathy [5][6][7][8] and preretinal or subretinal neovascularization, [9][10][11][12] suggesting that other compounds without the adverse effect of fibroblast or endothelial growth are necessary to achieve the establishment of pharmaceutical therapy for the retinal degeneration.…”

Section: Introductionmentioning

confidence: 99%

Retinal degeneration is delayed by tissue factor pathway inhibitor-2 in RCS rats and a sodium-iodate-induced model in rabbits

Obata

Yanagi

Tamaki

et al. 2004

Eye

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Purpose To investigate the in vivo effects of tissue factor pathway inhibitor 2 (TFPI-2), which stimulates proliferation of retinal pigment epithelial cells, but not the proliferation of fibroblast and vascular endothelial cells in vitro, on retinal degeneration using a sodium-iodate (SI)-induced model in rabbits and Royal Collage of Surgeons (RCS) rats. Methods 79 mg of recombinant TFPI-2 (rTFPI-2) or vehicle alone was injected intravitreously to 18 eyes of 12 pigmented rabbits a day after 20 mg/kg of SI was intravenously administered. Retinal function was assessed 4, 7, 14, and 21 days after the injection by analysing amplitudes of the c-wave of a bright flash electroretinogram. Additionally, 10 mg of rTFPI-2 or vehicle alone was injected intravitreously to 11 eyes of RCS rats at both 3 and 4 weeks old, then the retina was examined histologically at 5 weeks old. Results The rTFPI-2-treated eyes in rabbits showed a significantly less decrease in the relative amplitude of the c-wave than control eyes on days 4 and 7. The thickness of the outer nuclear layer was significantly thicker and the vacuole in the photoreceptor layer was less frequently observed in the rTFPI-2-treated RCS rats than the controls. Conclusions Intravitreal injection of TFPI-2 rescues SI-induced retinal degeneration in rabbits and naturally occurring retinal degeneration in RCS rats at least partly. These results may suggest that this compound can be utilized in the treatment of retinal degeneration.

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Basic Fibroblast Growth Factor Levels in the Vitreous of Patients With Proliferative Diabetic Retinopathy

Cited by 197 publications

References 30 publications

Kinetics of integrin expression in the mouse model of proliferative retinopathy and success of secondary intervention with cyclic RGD peptides

Kinetics of integrin expression in the mouse model of proliferative retinopathy and success of secondary intervention with cyclic RGD peptides

Regulation of VEGF mRNA expression and protein secretion by TGF-β2 in human retinal pigment epithelial cells

Retinal degeneration is delayed by tissue factor pathway inhibitor-2 in RCS rats and a sodium-iodate-induced model in rabbits

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