Basic fibroblast growth factor combined with extracellular matrix-inspired mimetic systems for effective skin regeneration and wound healing

Multifunctional type lll recombinant human collagen incorporated sodium alginate hydrogel with sustained release of extra cellular vehicles for wound healing multimodal therapy in diabetic mice

“…The extracellular microenvironment is severely damaged during the protracted inflammatory stage of chronic wounds, which ultimately leads to wound degradation [ 37 ]. Cellular inflammation in vascular tissue can be triggered by a variety of harmful stimuli, including damaged cells, irritants, and infections.…”

Electrospun Nanofiber Scaffolds Loaded with Metal-Based Nanoparticles for Wound Healing

“…The ECM is composed of a tightly organized network of nanoscale fibers, including collagen fibers, elastic fibers, fibronectin, and other components; it plays a crucial role in various stages of wound healing [ 3 ]. The process of wound healing generally consists of four stages: hemostasis, inflammation, proliferation, and remodeling [ 32 ]. When the skin is injured, platelets aggregate around the wound and, together with fibrinogen in the ECM, form a blood clot.…”

Customized Vascular Repair Microenvironment: Poly(lactic acid)-Gelatin Nanofibrous Scaffold Decorated with bFGF and Ag@Fe3O4 Core–Shell Nanowires

“…To this end, this study selected bFGF as a bioactive component. bFGF has effective therapeutic utilization in the treatment of skin ulcers and can enhance macrophage M2 polarization and vascular regeneration. − Silver can effectively eliminate bacteria, leveraging their inherent Ag + release feature and the photothermal effect. Ag + ions initiate a process where they interact with proteins and enzymes, thereby generating reactive oxygen species that assail bacterial DNA.…”