Basic characteristics of epileptiform discharges triggered by lindane in rats

Useinović, Nemanja; Vorkapić, Marko; Leković, Aleksa; Ademovič, Anida; Šutulović, Nikola; Grubač, Željko; Rašić-Marković, Aleksandra; Hrnčić, Dragan; Stanojlović, Olivera

doi:10.5937/mp69-18552

Cited by 1 publication

(3 citation statements)

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“…Ona omogućava detekciju prepoznatljivih patoloških obrazaca bioelektrične aktivnosti koji nastaju u mozgu u toku napada (12). Uprkos svojoj popularnosti, EEG ima nekoliko mana: zabeležena električna aktivnost predstavlja zbir ekscitatornih i inhibitiornih postsinaptičkih potencijala i ne odražava aktivnost pojedinačnih neurona, dakle, zahteva simultanu aktivnost većih kortikalnih zona da bi se proizveo detektabilni signal (13). Metoda je podložna i nastanku artefakta i bez korelirajućih kliničkih nalaza ima diskutabilnu ulogu u postavljanju dijagnoze i prognoziranju epilepsije kod pacijenata (14).…”

Section: Uvodunclassified

“…Prethodne studije epileptičnih pražnjenja uspele su da opišu tri različita obrasca iktalnog EEG-a: 1) oscilacije visokih frekvencija koje su prethodile konvulzijama, 2) talase usporene aktivnosti i 3) desinhronizaciju električne aktivnosti (13). Naša studija takođe pokazuje značajan udeo nižefrekventnih opsega u iktalnim periodima.…”

Section: Diskusijaunclassified

“…Naša studija takođe pokazuje značajan udeo nižefrekventnih opsega u iktalnim periodima. Utvrđen je, međutim, i visok udeo talasa u frekventnom opsegu alfa ritma (7)(8)(9)(10)(11)(12)(13)(14)(15). Iktalne periode karakteriše preovladavanje alfa i teta talasa.…”

Section: Diskusijaunclassified

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Basic characteristics of EEG epileptiform discharges triggered by lindane in a model of experimental prostatitis

Zubelić¹,

Vuletić²,

Ašćerić³

et al. 2022

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Introduction: Chronic prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) is the most commonly diagnosed non-infectious prostatitis in urology. Studies have shown that CP/CPPS can induce neuroinflammation, which may result in CNS hyperexcitability and a tendency to develop epileptic seizures. Spike salvos are ictal EEG graph elements typical for the experimental model of lindane-induced seizures. There are a number of mathematical models for quantitative analysis of EEG, including the Fast Fourier Transform (FFT). It transforms the signal from time into the frequency domain, providing information on Power Spectral Densities (PSD). Aim: The aim of this study was to investigate the basic characteristics of epileptiform discharges induced by subconvulsive dose of lindane in rats, with experimentally induced CP/CPPS. Material and methods: CP/CPPS was induced by intraprostatic injection of 3% l-carrageenan in male Wistar albino rats. Animals with CP/CPPS were implanted with EEG registration electrodes, and then administered lindane (4 mg/kg, i.p, experimental group, n = 6 per group) or its solvent (DMSO, control group, n = 6 per group). An 8-channel EEG device was used in combination with software developed in the laboratory (NeuroSciLaBG). Ictal EEG epochs were extracted from the original signal and FFT analysis was performed to obtain information taking into account PSD in predefined frequency bands. Results: There was no ictal activity in the EEG of control animals. In experimental animals, ictal activity occurred and the mean duration of the ictal period was 2.06 s. FFT analysis revealed that the Alpha frequency range (7-15 Hz) was markedly dominant during ictal activity. Conclusion: The results of this study showed the characteristics of epileptiform discharges in animals with experimentally induced CP/CPPS. This study and animal model are suitable for future translational studies of the comorbidities of this syndrome.

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Section: Uvodunclassified

Section: Diskusijaunclassified