Basic biochemical and hematological parameters in perinatal asphyxia and their correlation with hypoxic ischemic encephalopathy

Abstract

Perinatal hypoxic-ischemic encephalopathy (HIE) represents a major cause of neonatal death or long-term disability. Inflammation plays an important role in mediating brain damage induced by neonatal hypoxic-ischemic encephalopathy. The mechanisms underlying the inflammatory response in hypoxia and ischemia are complex and are still being extensively researched. The objective of this study was to determine the predictive value of peak lactate dehydrogenase (LDH), C-reactive protein (CRP), procalcitonin (PCT) and of the evolution of leukocytes, neutrophils and lymphocytes in the first 96 h after birth for the grade of encephalopathy and neurodevelopmental outcome in newborns with HIE. In order to reveal this relationship we used comparisons between the above mention parameters. The observed hematological changes were nonspecific. The vast majority of the 78 newborns included in the study had PCT values above normal in the first 24 h, contrasting with CRP values that were positive in only 15.8% of the patients. A total of 76.9% of the patients had LDH values higher than the upper limit of normal values. The mean LDH values in patients with an unfavorable prognosis were 1,235 U/l. We can conclude that LDH is a good predictor of HIE in the first 12/24 h after birth.

Noninfectious influencers of early-onset sepsis biomarkers

“…58 , 59 , 67 Higher levels of procalcitonin and IL-6 levels are also reported in neonates and adults receiving TH. 63 , 64 , 68 The cut-off values proposed for IL-6 levels in sepsis diagnosis vary from <10 pg/mL to over 300 pg/mL. 69 Among 22 infants with HIE and without infection, IL-6 median levels were 198.2 pg/mL (IQR: 49.8–358.3) and 101.9 pg/mL (IQR: 24.9–562.9) on day 1 and 2, respectively.…”

Comparative Evaluation of the Potential Antitumor of Helleborus purpurascens in Skin and Breast Cancer

“…Figure 5 shows a possible mechanism of action of Hpex. In light of the fact that flavonoids are antioxidant compounds [63] and that reactive oxygen species contribute to the development of cancer [64] and other chronic pathologies, such as cardiovascular disease [65,66], diabetes mellitus [67,68], endothelial dysfunction [69,70], or neurological pathologies [71], this study examined the antioxidant activity of the hydroalcoholic extract of H. purpurascens. A 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay was applied to evaluate the antioxidant activity of four extract concentrations (10, 25, 50, and 100 μg/mL).…”

“…Its remarkable antioxidant properties are due to the compounds that were found in H. purpurascens extract, which have been associated with the neutralization of oxygen-free species [72]. The antioxidant activity of flavonoids is mainly based on five mechanisms of action, as follows: (i) due to the -OH group in the structure of flavonoids, they interact directly In light of the fact that flavonoids are antioxidant compounds [63] and that reactive oxygen species contribute to the development of cancer [64] and other chronic pathologies, such as cardiovascular disease [65,66], diabetes mellitus [67,68], endothelial dysfunction [69,70], or neurological pathologies [71], this study examined the antioxidant activity of the hydroalcoholic extract of H. purpurascens. A 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay was applied to evaluate the antioxidant activity of four extract concentrations (10,25,50, and 100 µg/mL).…”

Oral squamous cell carcinomas: a histopathological review of multiple cases from Western Romania

“…Different molecular markers have been evaluated to characterize new prognostic markers and to identify new therapeutic targets. The change in the balance between prooxidants and antioxidants is manifested by oxidative stress, which leads to certain microcirculation deficits and endothelial dysfunctions with excessive growth of free radicals [ 11 ].…”