Basic approaches to the synthesis of pyrrolo[1,2-a]quinolines derivatives: a review

doi:10.32434/0321-4095-2019-127-6-6-16

Cited by 3 publications

(2 citation statements)

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“…Considering the biological relevance of these two important scaffolds and the positive tendency for their further development, pyrrolo(iso)quinoline derivatives have increasingly become targets of interest in the organic synthetic community. Over the past decades, several synthetic methodologies to generate compounds with pyrrolo[2,1-a]isoquinoline or pyrrolo [1,2-a]quinoline cores have been developed, including the [3 + 2] cycloaddition of the corresponding cycloimmonium ylides to various dipolarophiles, cyclization of lactam derivatives, intramolecular cyclizations, as well as several transition metal catalyzed C-C and C-N bond formation reactions [3,6,16]. It is worth mentioning that the nature and the position of the substituents in the core-containing compounds define their biological profile.…”

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confidence: 99%

Synthesis and Biological Screening of New Cyano-Substituted Pyrrole Fused (Iso)Quinoline Derivatives

et al. 2021

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Several new cyano-substituted derivatives with pyrrolo[1,2-a]quinoline and pyrrolo[2,1-a]isoquinoline scaffolds were synthesized by the [3 + 2] cycloaddition of (iso)quinolinium ylides to fumaronitrile. The cycloimmonium ylides reacted in situ as 1,3-dipoles with fumaronitrile to selectively form distinct final compounds, depending on the structure of the (iso)quinolinium salt. Eleven compounds were evaluated for their anticancer activity against a panel of 60 human cancer cell lines. The most potent compound 9a showed a broad spectrum of antiproliferative activity against cancer cell lines representing leukemia, melanoma and cancer of lung, colon, central nervous system, ovary, kidney, breast and prostate cancer. In vitro assays and molecular docking revealed tubulin interaction properties of compound 9a.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Biological Screening of New Cyano-Substituted Pyrrole Fused (Iso)Quinoline Derivatives

et al. 2021

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“…The treatment of discharged water at machinebuilding enterprises, which contains a considerable quantity of metal chips and used lubricating-cooling fluid (LCF), is pertaining to great technical difficulties as the emulsions differ with resistance and weak biological oxidability of mineral oil. They take the mechanical, physico-chemical and biological cleaning methods very hard [6][7][8][9]. In most cases, the operation wastewater form lowconcentration suspension containing fine particles with dimensions of 0.1-15 micrometer.…”

Section: Introductionmentioning

confidence: 99%

Mathematical Modeling of Motion of the Solid Particles in the Filter-Coalescer Wastewater Treatment

Safarov

2023

GEOMATE

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The purpose of this article is to describe the method of calculation of the motion of particles in the filter-coalescer wastewater treatment based on the mathematical description of the motion of the cleaning fluid and the particles in the channel coagulator. It is found that fine particles in the coagulator move in a stream so that the process of consolidation and coalescence occurs at specific sites in the gap between the cones, with little flow velocity vector changes in direction and magnitude that the process provides an efficient aggregation of particles. The length of this section should be sufficient to ensure that the bulk of the particles reach a critical size. This allows the particles to migrate subsequent channel sections coagulator holding particles in the flow, and eliminating such deposition of particles on the internal surfaces of the device even when moving within the annular gap. The scheme of the electromagnetic filter of the coagulator, the two-dimensional scheme of the magnetic coagulator, the scheme of epure of speed vectors in the canal of the coagulator and the scheme of particle interaction in the canal of the coagulator are given too.

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Prospects for the use of growth regulators in vegetative propagation technology of La-vandula angustifolia

Kobets,

Derevianko,

Zavhorodnii

et al. 2024

Regul. Mech. Biosyst.

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Lavenders include some 28 species of evergreen aromatic shrubs and subshrubs belonging to the mint family, the Lamiaceae. They occur mainly around the Mediterranean and their flowers range from pink to purple and white. It is known that Lavandula angustifolia Mill. is an unpretentious decorative and essential oil crop that is widely used in the pharmaceutical, cosmetic, and food industries. Therefore, the planting material of this crop is in great demand in Ukraine. Cultivated varieties of lavender are very different for vegetative reproduction. A promising path is the testing for new effective and environmentally friendly rooting stimulants. The experiments were conducted in the Horticulture Laboratory of the Khortytsiа National Academy. The study tested the influence of aqueous solutions of a complex of amino acids, polypeptides, amino sugars, hexuronic acids, and microelements called “Bioglobin”, a complex of inorganic compounds containing (nitrogen – 4.7%, phosphorus – 3.4%, potassium – 4.6%, iron – 1.6%, zinc – 1.6%) and organic compounds (alginate acid, betaine, polysaccharides, vitamin complex of groups B, C, D) called “Ferti Root”, a complex of saturated and unsaturated fatty acids (C14–C28), polysaccharides, 15 amino acids, analogs of cytokinin and auxin nature phytohormones called “Emistim S”, a complex of 2.6-dimethylpyridine-1-oxide with α-phenylacetic acid called “Charkor”, disodium salt of 2-(quinolin-4-ylthio) succinic acid on the rooting and development of varieties "Stepova", "Vdala", "Sineva" one-year woodcuttings. The indicators were evaluated in comparison with the control without processing the cuttings before planting, and with the use of (4-(indol-3-yl) butyric acid) called “Kornevin”. Mother plants are 2–3 years old. The experiment was repeated three times, 30 cuttings each. Woodсuttings were planted in open-door ground at early October. In May, the number of rooted cuttings, as well as the number and length of roots was counted. It was found that two preparations had the maximum positive effect on the cuttings rooting: disodium salt of 2-(quinolin-4-ylthio) succinic acid at a concentration of 5 mg/L and “Ferti Root”. Consequently, the rooting percentage increased by 18–20% in all researched varieties compared to the control. The length and number of new formed roots in these experimental versions exceeded the control indicators by 1.5–2.0 times. Other researched preparations did not show a positive effect on the rooting cuttings indicators.

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Basic approaches to the synthesis of pyrrolo[1,2-a]quinolines derivatives: a review

Cited by 3 publications

References 64 publications

Synthesis and Biological Screening of New Cyano-Substituted Pyrrole Fused (Iso)Quinoline Derivatives

Synthesis and Biological Screening of New Cyano-Substituted Pyrrole Fused (Iso)Quinoline Derivatives

Mathematical Modeling of Motion of the Solid Particles in the Filter-Coalescer Wastewater Treatment

Prospects for the use of growth regulators in vegetative propagation technology of La-vandula angustifolia

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