Basic Approach to Veterinary Care of Rabbits

Brandão, João; Graham, Jennifer E.; Quesenberry, Katherine E.

doi:10.1016/b978-0-323-48435-0.00012-5

Cited by 5 publications

(5 citation statements)

References 35 publications

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“…It is possible that a hepatic malfunction was a consequence of intensive production or use of P. dulce. However, biochemical parameters were normal as indicated by Brandão et al [33]. Aljohani and Abduljawad [34] reported similar concentrations of alanine and aspartate transferase in rabbits fed with Moringa oleifera, although values reported in their study were higher than those obtained in this experiment.…”

Section: Discussionsupporting

confidence: 46%

Dietary Supplementation with Pithecellobium dulce (Roxb) Benth Fruits to Fattening Rabbits

Apáez-Barrios,

Ocampo-López,

Soto-Simental

et al. 2023

Animals

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Pithecellobium dulce produces a fruit used in alternative medicine that could be utilized to feed rabbits. The objective of this study was to measure the effect of the P. dulce fruit on productive performance, carcass traits, meat characteristics, and meat product quality as well as shelf-life. Seventy-two California × English pot crossbreed rabbits (35 d age) were randomly distributed into two treatments: a control group without P. dulce and another group fed with 5% of P. dulce, and fattening for 28 d. Productive performance parameters, blood biochemistry and hematology, apparent digestibility, carcass traits, meat characteristics, and meat product shelf-life were measured. The results indicate inclusion of 5% P. dulce improves (p < 0.05) dry and organic matter digestibility and feed conversion rate, but some serum blood enzymes were increased (p < 0.05). The a* value, hardness, and pH decreased (p < 0.05) in the group fed with P. dulce. Antioxidant properties in the meatballs were different (p < 0.05), improving shelf-life and acceptance in sensory analysis. In conclusion, the use of 0.5% of P. dulce fruits to feed fattening rabbits can be used to improve the shelf-life of rabbit meat.

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Section: Discussionsupporting

confidence: 46%

Dietary Supplementation with Pithecellobium dulce (Roxb) Benth Fruits to Fattening Rabbits

Apáez-Barrios,

Ocampo-López,

Soto-Simental

et al. 2023

Animals

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“…The formulation of the drug administered here (in hemp oil) allows for ease of dose adjustment by the practitioner, as rabbits are more amenable to receiving liquid suspensions as opposed to tablets or capsules. 23 Limitations of our study include a small sample size (n = 6) and single-dose administration. A longer duration of administration would be beneficial to assess trends in CBD and CBDA concentration over time, and to monitor for adverse effects with longer term or chronic administration.…”

Section: Discussionmentioning

confidence: 97%

Feeding decreases the oral bioavailability of cannabidiol and cannabidiolic acid in hemp oil in New Zealand White rabbits (Oryctolagus cuniculus)

Rooney

Carpenter

KuKanich

et al. 2022

ajvr

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OBJECTIVE To determine the pharmacokinetics of a solution containing cannabidiol (CBD) and cannabidiolic acid (CBDA), administered orally in 2 single-dose studies (with and without food), in the domestic rabbit (Oryctolagus cuniculus). ANIMALS 6 healthy New Zealand White rabbits. PROCEDURES In phase 1, 6 rabbits were administered 15 mg/kg CBD with 16.4 mg/kg CBDA orally in hemp oil. In phase 2, 6 rabbits were administered the same dose orally in hemp oil followed by a food slurry. Blood samples were collected for 24 hours to determine the pharmacokinetics of CBD and CBDA. Quantification of plasma CBD and CBDA concentrations was determined using a validated liquid chromatography–mass spectrometry (LC-MS) assay. Pharmacokinetics were determined using noncompartmental analysis. RESULTS For CBD, the area under the curve extrapolated to infinity (AUC)0–∞ was 179.8 and 102 hours X ng/mL, the maximum plasma concentration (Cmax) was 30.4 and 15 ng/mL, the time to Cmax (tmax) was 3.78 and 3.25 hours, and the terminal half-life (t1/2λ) was 7.12 and 3.8 hours in phase 1 and phase 2, respectively. For CBDA, the AUC0–∞ was 12,286 and 6,176 hours X ng/mL, Cmax was 2,573 and 1,196 ng/mL, tmax was 1.07 and 1.12 hours, and t1/2λ was 3.26 and 3.49 hours in phase 1 and phase 2, respectively. Adverse effects were not observed in any rabbit. CLINICAL RELEVANCE CBD and CBDA reached a greater Cmax and had a longer t1/2λ in phase 1 (without food) compared with phase 2 (with food). CBDA reached a greater Cmax but had a shorter t1/2λ than CBD both in phase 1 and phase 2. These data may be useful in determining appropriate dosing of cannabinoids in the domestic rabbit.

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“…On the contrary, the availability of oral suspensions of meloxicam is wide. Administration of tablets in rabbits is difficult, and suspensions are preferred [ 50 ]: for this reason, meloxicam is one of the most prescribed drugs to rabbit owners [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Comparison between Carprofen and Meloxicam for Post-Neutering Pain Management in Pet Rabbits

Serpieri,

Ottino,

Bonaffini

et al. 2024

Veterinary Sciences

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Surgical neutering in pet rabbits is common practice to prevent reproduction and associated health issues. Adequate postoperative pain management is crucial for recovery, yet effective methods in clinical settings remain underexplored. This study compared the analgesic effects of carprofen and meloxicam in pet rabbits undergoing surgical neutering. Fifty rabbits of varied demographics were included, with pain assessed using the Centro Animali Non Convenzionali Rabbit Scale (CANCRS). Rabbits were allocated to receive postoperative 2 mg kg−1 carprofen or 1 mg kg−1 meloxicam by subcutaneous injection. Anesthesia was induced with an intramuscular combination of ketamine (20 mg kg−1), medetomidine (0.4 mg kg−1), and butorphanol (0.2 mg kg−1), and ovariectomy or orchiectomy were performed. The CANCRS scale was used to assess pain by evaluating the rabbit preoperatively, 6 h postoperatively, and at three time points the following day. Times of return to spontaneous feeding and fecal production were also recorded. No statistically significant difference was found between treatment groups based on CANCRS scores and resumption of food intake and fecal output. No clinically detectable adverse effects were noted. While limitations include the use of a single pain assessment scale and the absence of a placebo control group, the results suggest that both carprofen and meloxicam can be viable options in clinical practice. Further research utilizing diverse pain assessment methods is warranted to enhance understanding and optimize pain management strategies for rabbits undergoing surgical procedures.

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Basic Approach to Veterinary Care of Rabbits

Cited by 5 publications

References 35 publications

Dietary Supplementation with Pithecellobium dulce (Roxb) Benth Fruits to Fattening Rabbits

Dietary Supplementation with Pithecellobium dulce (Roxb) Benth Fruits to Fattening Rabbits

Feeding decreases the oral bioavailability of cannabidiol and cannabidiolic acid in hemp oil in New Zealand White rabbits (Oryctolagus cuniculus)

Comparison between Carprofen and Meloxicam for Post-Neutering Pain Management in Pet Rabbits

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