Bases fisiopatológicas de los síntomas no motores de la enfermedad de Parkinson

Erro, M.E.; Arroyo, María Perla Moreno; Zandio, B.

doi:10.33588/rn.50s02.2009734

Cited by 2 publications

(2 citation statements)

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“…34 In addition, interventions known to ameliorate motor symptoms, rigidity included, may also improve pain, but in these instances pain improvement is not necessarily correlated to rigidity control. 24,33,133 It means that in instances of rigidity and pain, it is usually not possible to ascertain that pain is specifically caused by rigidity and not by another peripheral nociceptive driving factor that is centrally augmented. Hence, in a pragmatic approach, the finding of rigidity and pain could classify pains as nociceptive, thus acknowledging that MSK system is to some degree contributing to the occurrence of pain as a peripheral pain generator is being centrally overamplified.…”

Section: Discussionmentioning

confidence: 99%

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Pain in Parkinson disease: mechanistic substrates, main classification systems, and how to make sense out of them

Andrade

Mylius

Pérez-Lloret

et al. 2023

Pain

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Parkinson disease (PD) affects up to 2% of the general population older than 65 years and is a major cause of functional loss. Chronic pain is a common nonmotor symptom that affects up to 80% of patients with (Pw) PD both in prodromal phases and during the subsequent stages of the disease, negatively affecting patient's quality of life and function. Pain in PwPD is rather heterogeneous and may occur because of different mechanisms. Targeting motor symptoms by dopamine replacement or with neuromodulatory approaches may only partially control PD-related pain. Pain in general has been classified in PwPD according to the motor signs, pain dimensions, or pain subtypes. Recently, a new classification framework focusing on chronic pain was introduced to group different types of PD pains according to mechanistic descriptors: nociceptive, neuropathic, or neither nociceptive nor neuropathic. This is also in line with the International Classification of Disease-11, which acknowledges the possibility of chronic secondary musculoskeletal or nociceptive pain due to disease of the CNS. In this narrative review and opinion article, a group of basic and clinical scientists revise the mechanism of pain in PD and the challenges faced when classifying it as a stepping stone to discuss an integrative view of the current classification approaches and how clinical practice can be influenced by them. Knowledge gaps to be tackled by coming classification and therapeutic efforts are presented, as well as a potential framework to address them in a patient-oriented manner.

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Section: Discussionmentioning

confidence: 99%

“…Importantly, nonmotor symptoms occur due to disease affecting multiple organs and systems and are not all dependent on dopaminergic modulation. 15,28,29,33,79,109,130,132,133…”

Section: Introductionmentioning

confidence: 99%

Pain in Parkinson disease: mechanistic substrates, main classification systems, and how to make sense out of them

Andrade

Mylius

Pérez-Lloret

et al. 2023

Pain

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REPRINTED WITH PERMISSION OF IASP – PAIN 164 (2023) 2425–2434: Pain in Parkinson disease: mechanistic substrates, mainclassification systems, and how to make sense out of them

Ciampi de Andrade,

Mylius,

Perez-Lloret

et al. 2024

Ból

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Parkinson disease (PD) affects up to 2% of the general population older than 65 years and is a major cause offunctional loss. Chronic pain is a common nonmotor symptom that affects up to 80% of patients with (Pw) PD bothin prodromal phases and during the subsequent stages of the disease, negatively affecting patient’s quality of lifeand function. Pain in PwPD is rather heterogeneous and may occur because of different mechanisms. Targetingmotor symptoms by dopamine replacement or with neuromodulatory approaches may only partially control PD---related pain. Pain in general has been classified in PwPD according to the motor signs, pain dimensions, or painsubtypes. Recently, a new classification framework focusing on chronic pain was introduced to group different typesof PD pains according to mechanistic descriptors: nociceptive, neuropathic, or neither nociceptive nor neuropathic.This is also in line with the International Classification of Disease-11, which acknowledges the possibility of chronicsecondary musculoskeletal or nociceptive pain due to disease of the CNS. In this narrative review and opinionarticle, a group of basic and clinical scientists revise the mechanism of pain in PD and the challenges faced whenclassifying it as a stepping stone to discuss an integrative view of the current classification approaches and howclinical practice can be influenced by them. Knowledge gaps to be tackled by coming classification and therapeuticefforts are presented, as well as a potential framework to address them in a patient oriented manner.

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Bases fisiopatológicas de los síntomas no motores de la enfermedad de Parkinson

Cited by 2 publications

References 0 publications

Pain in Parkinson disease: mechanistic substrates, main classification systems, and how to make sense out of them

Pain in Parkinson disease: mechanistic substrates, main classification systems, and how to make sense out of them

REPRINTED WITH PERMISSION OF IASP – PAIN 164 (2023) 2425–2434: Pain in Parkinson disease: mechanistic substrates, mainclassification systems, and how to make sense out of them

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