Basement membrane thickening and clinical features of children with asthma

Kim, E. S.; Kim, S. H.; Kim, K. W.; Kim, Y. S.; Sohn, Myung Hyun; Kim, K.-E.

doi:10.1111/j.1398-9995.2007.01375.x

Cited by 35 publications

(32 citation statements)

References 29 publications

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“…Similar to the findings in adult asthma patients, the thickening of RBM was present in children with severe asthma. Kim et al [25] also found basement membrane thickening in children with asthma. Cokugras et al [21] studied 10 moderate asthmatic children with a mean disease duration of 4.8 years, who were treated with sodium cromoglycate for 2.0 years and had received inhaled steroids and bronchodilators for 8 months.…”

Section: Review Articlementioning

confidence: 92%

Airway remodeling: a potential therapeutic target in asthma

Zhang¹,

2011

World J Pediatr

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Section: Review Articlementioning

confidence: 92%

Airway remodeling: a potential therapeutic target in asthma

Zhang¹,

2011

World J Pediatr

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“…A key feature in the pathogenesis of asthma is chronic airway inflammation, characterized by the presence of inflammatory cells and the release of inflammatory mediators in the airways (2). Airway inflammation can be detected by several methods such as bronchial biopsy, bronchoalveolar lavage or induced sputum (3). However, due to their invasive character or low practical applicability, these methods are not suitable for use in young children or in large study populations.…”

Section: Introductionmentioning

confidence: 99%

Exhaled Nitric Oxide is Associated with Allergic Inflammation in Children

et al. 2011

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Exhaled nitric oxide (eNO) has been proposed as a noninvasive marker of airway inflammation in asthma. In asthmatic patients, exhaled NO levels have been shown to relate with other markers of eosinophilic recruitment, which are detected in blood, sputum, bronchoalveolar lavage fluid and bronchial biopsy samples. The purpose of this study was to assess the possible relationship between eNO and allergic inflammation or sensitization in childhood asthma and allergic rhinitis. Subjects consisted of 118 asthmatic children, 79 patients with allergic rhinitis, and 74 controls. Their age ranged from 6 to 15 yr old. eNO level, peripheral blood eosinophil count, eosinophil cationic protein (ECP), serum total IgE level and specific IgE levels were measured. Methacholine challenge test and allergic skin prick test for common allergens were performed in all subjects. Atopic group (n = 206, 44.48 ± 30.45 ppb) had higher eNO values than non-atopic group (n = 65, 20.54 ± 16.57 ppb, P < 0.001). eNO level was significantly higher in patients with asthma (42.84 ± 31.92 ppb) and in those with allergic rhinitis (43.59 ± 29.84 ppb) than in healthy controls (27.01 ± 21.34 ppb, P < 0.001) but there was no difference between asthma and allergic rhinitis group. eNO also had significant positive correlations with Dermatophagoides pteronyssinus IgE level (r = 0.348, P < 0.001), Dermatophagoides farinae IgE level (r = 0.376, P < 0.001), and the number of positive allergens in skin prick test (r = 0.329, P = 0.001). eNO had significant positive correlations with peripheral blood eosinophil count (r = 0.356, P < 0.001), serum total IgE level (r = 0.221, P < 0.001), and ECP (r = 0.436, P < 0.001). This study reveals that eNO level is associated with allergic inflammation and the degree of allergic sensitization.

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“…In this regard, however, even in mild recently diagnosed asthma or in childhood asthma, significant airway remodelling can already be observed, although more needs to be known with regard to the reversibility of some of the changes at this early stage [13][14][15].…”

Section: What Are the Remaining Questions?mentioning

confidence: 99%