Basement membrane-related and type III procollagen-related antigens in serum of patients with chronic viral liver disease

Misaki, Moriharu; Shima, Teruo; Yano, Yutaka; Y, Sumita; Kano, U; Murata, Tetsuya; Watanabe, Shozo; Suzuki, Shiro

doi:10.1093/clinchem/36.3.522

Cited by 49 publications

(11 citation statements)

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“…In our series the highest values of laminin were observed in cirrhotic patients, as in previous studies (39,40). During interferon therapy we noted a decrease in the mean concentrations of laminin in patients who responded, although this reduction was not significant.…”

Section: Discussionsupporting

confidence: 86%

Serum markers of hepatic fibrogenesis in chronic hepatitis type C treated with alfa‐2A interferon

Gallorini¹,

Plebani²,

Pontisso³

et al. 1994

Liver

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Hepatic fibrogenesis is a dynamic process which characterizes the course of chronic hepatitis. It has stimulated interest in the possible effect of interferon therapy on liver fibrosis. We have evaluated a panel of serum markers of fibrogenesis, namely N‐terminal procollagen III peptide (PII‐INP), C‐terminal procollagen I peptide (PICP), laminin and hyaluronate in 35 patients with chronic hepatitis type C, before, during and after interferon treatment. Before treatment, PIIINP was elevated in 8.5%, 44% and 71% of patients with chronic persistent hepatitis, chronic active hepatitis and cirrhosis, respectively, while the corresponding figures for PICP were 0%, 50% and 46%, and for laminin 16.5%, 70% and 71%; hyaluronate was elevated in only five out of seven patients with cirrhosis. Patients with high PIIINP levels at presentation and a persistent response to treatment showed persistent normalization of this parameter, which was not observed in non‐responders. In contrast, the other markers showed no significant correlation with interferon response. These results indicate that PIIINP correlates with interferon response in chronic hepatitis type C.

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Section: Discussionsupporting

confidence: 86%

Serum markers of hepatic fibrogenesis in chronic hepatitis type C treated with alfa‐2A interferon

Gallorini¹,

Plebani²,

Pontisso³

et al. 1994

Liver

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“…In fact, the presence of collagen fragments in the serum has been used as a diagnostic marker for cirrhosis. For example, the presence of fragments of type IV and type III collagen (Misaki et al, 1990), fragment of type IV collagen (Obata et al, 1989) and the fragments of type IV collagen and 7S do- Fig. 4.…”

Section: Discussionmentioning

confidence: 98%

“…Various serum markers that can be used to evaluate the progression of hepatic fibrosis have also been reported (Tanikawa, 1994;Tsutsumi et al, 1996). Pro-type III collagen and the triplehelical domain and 7S domain of type IV collagen are used as the serum markers for cirrhosis (Obata et al, 1989;Misaki et al, 1990;Murawaki et al, 1996). In cirrhosis, several types of collagen increase at various ratios (Rojkind and Ponce-Noyola, 1982;Murata et al, 1984).…”

mentioning

confidence: 99%

Type V Collagen Distribution in Liver Is Reconstructed in Coculture System of Hepatocytes and Stellate Cells; The Possible Functions of Type V Collagen in Liver under Normal and Pathological Conditions.

Takai

Hattori

Irie

2001

Cell Struct. Funct.

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The contents of type I, type III and type V collagen and the collagen type specific distributions in liver under normal and cirrhotic conditions were examined. In CCl4 injected rat, the increasing amount of type V collagen was a specific event during the progression of cirrhosis. In normal liver, immunohistochemical observation showed that type V collagen was localized on the fine fibrils, while type I was localized on the thick fibril. Type V collagen was partially colocalized with type IV collagen. In the cirrhotic liver, type V collagen was localized on the margin of the thick fibrous septa along with type IV collagen. Type I collagen existed in the core region of fibrous septa where the stellate cells were prominent. To elucidate the mechanism of the type specific deposition of collagen in the liver, we constructed a coculture system using both stellate cells and hepatocytes. In this system, type V collagen was mainly deposited on hepatocyte colonies not on stellate cells, while type I collagen fibrils were localized on stellate cells. The spatial positioning of type I and type V collagens in vitro was similar to that in the liver. In the cell adhesion assay, the adhesion of stellate cells to type V collagen was poorer than that of the hepatocytes. The collagen type-specific affinity of the stellate cells and hepatocytes may explain the specific localization of type V collagen in the liver and coculture system. These results suggested that the functions of type V collagen are not only to connect type IV collagen with type I collagen fibril, but also to protect the parenchyma from excess type I collagen deposition produced by stellate cells under pathological conditions.

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“…The fibrillar collagens, types I and III, become the main ECM proteins produced by hepatic stellate cell (HSC) that has been activated by pathogenic changes in the hepatic cells and tissues. Several reports have shown that expression of collagen type III alpha 1 ( COL3A1 ) is increased in viral (HBV and hepatitis C virus) or alcohol related‐liver diseases including chronic liver diseases (7), liver fibrosis (8, 9), liver cirrhosis (CIR) (10, 11), and HCC (12). Moreover, synthetic analogues of Arg‐Gly‐Asp (RGD) have been shown to inhibit integrin‐mediated cell function between T lymphocytes and ECM in acute liver injury (13).…”

Section: Introductionmentioning

confidence: 99%

Genetic association between functional haplotype of collagen type III alpha 1 and chronic hepatitis B and cirrhosis in Koreans

Lee

Kim

et al. 2008

Tissue Antigens

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Collagen type III alpha 1 (COL3A1) is one of the extracelluar matrix (ECM) proteins. The expression of COL3A1 is closely related to chronic liver diseases. In this study, we investigated whether single nucleotide polymorphisms (SNPs) of COL3A1 confer genetic susceptibility to patients with hepatitis B virus-infected liver diseases including chronic hepatitis B (CH), liver cirrhosis (CIR), and hepatocellular carcinoma (HCC). A total of 399 Korean (KOR) people, 111 patients with CH, 95 patients with CIR, 86 patients with HCC, and 107 spontaneously recovery, were genotyped for 16 SNPs of the COL3A1 gene.

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Basement membrane-related and type III procollagen-related antigens in serum of patients with chronic viral liver disease

Cited by 49 publications

References 0 publications

Serum markers of hepatic fibrogenesis in chronic hepatitis type C treated with alfa‐2A interferon

Serum markers of hepatic fibrogenesis in chronic hepatitis type C treated with alfa‐2A interferon

Type V Collagen Distribution in Liver Is Reconstructed in Coculture System of Hepatocytes and Stellate Cells; The Possible Functions of Type V Collagen in Liver under Normal and Pathological Conditions.

Genetic association between functional haplotype of collagen type III alpha 1 and chronic hepatitis B and cirrhosis in Koreans

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