Basement membrane peptides as markers of liver disease in chronic hepatitis C

Diagnosis and Quantitation of Fibrosis

“…96,99 Serum levels of laminin and the laminin P1 fragment are elevated in patients with chronic liver disease due to alcohol and viral hepatitis. 100 Laminin appears to be superior to PIIINP but inferior to type IV collagen in predicting fibrosis in chronic viral hepatitis. 101 …”

Non-invasive assessment of liver fibrosis in chronic hepatitis C

“…These include: glycoproteins, such as serum hyaluronate [13][14][15][16][17], laminin [18,19], and YKL-40 [20]; the collagens family, such as procollagen III N-peptide (PIIINP) [13] and type IV collagen [21]; collagenases and their inhibitors, such as matrix metalloproteases (MMP) [22] and tissue inhibitory metalloprotease-1 (TIMP-1) [23].…”

A Chemotactic Peptide from Laminin α5 Functions as a Regulator of Inflammatory Immune Responses via TNFα-mediated Signaling

“…During tissue remodeling, increased turnover of ECM can result in release of degradation products of ECM components. The presence of laminin or laminin fragments has been demonstrated in several chronic inflammatory diseases, including chronic hepatitis (17,18), diffuse interstitial lung diseases (19), renal diseases (16), and inflammatory bowel diseases (21). TNF-␣ has also been shown to be increased in many of these chronic inflammatory diseases (63)(64)(65)(66).…”

“…However, fragments of fibronectin (11) and hyaluronan stimulate macrophage (M) cytokine production (12)(13)(14), suggesting that ECM components may have regulatory roles in inflammatory responses. Although fragments of BM components, such as laminins, type IV collagen, and entactin, have been detected in biological fluids in association with various inflammatory diseases (15)(16)(17)(18)(19)(20)(21), it is unknown whether BM components are active in the regulation of inflammation.…”