Basement membrane components are key players in specialized extracellular matrices

Kruegel, Jenny; Miosge, Nicolai

doi:10.1007/s00018-010-0367-x

Cited by 206 publications

(167 citation statements)

References 194 publications

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“…57,58 Therefore, NKp44-NID1 interactions are likely to occur in tissues, namely in the mucosae, which contain both NK cells and ILC3, expressing NKp44 receptor. 59-61 The role of NKp44 in regulating the function of these cells has not been clearly defined.…”

Section: Discussionmentioning

confidence: 99%

“…70 In addition, NID1 can interact with different BM/ECM proteins including laminin, collagen type IV, and perlecan. 57,58 Thus, it is possible that the tissue microenvironment and the molecular context may further influence the functional outcome of the NID1-NKp44 interaction. The ability of NKp44 to recognize NID1 glycoprotein both in denatured and native conditions indicates that NKp44 may bind to a linear epitope.…”

Section: Discussionmentioning

confidence: 99%

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Nidogen-1 is a novel extracellular ligand for the NKp44 activating receptor

et al. 2018

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The release of soluble ligands of activating Natural Killer (NK) cell receptors may represent a regulatory mechanism of NK cell function both in physiologic and in pathologic conditions. Here, we identified the extracellular matrix protein Nidogen-1 (NID1) as a ligand of NKp44, an important activating receptor expressed by activated NK cells. When released as soluble molecule, NID1 regulates NK cell function by modulating NKp44-induced IFN-γ production or cytotoxicity. In particular, it also modulates IFN-γ production induced by Platelet-Derived Growth Factor (PDGF)-DD following NKp44 engagement. We also show that NID1 may be present at the cell surface. In this form or when bound to a solid support (bNID1), NID1 fails to induce NK cell cytotoxicity or cytokine release. However, analysis by mass spectrometry revealed that exposure to bNID1 can induce in human NK cells relevant changes in the proteomic profiles suggesting an effect on different biological processes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Nidogen-1 is a novel extracellular ligand for the NKp44 activating receptor

et al. 2018

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“…Accordingly, the functional role of Hydra ECM in a variety of its cellular and developmental processes is seen replicated in more complicated vertebrate systems (Kim et al., 2011;Kruegel and Miosge, 2010;Watt and Fujiwara, 2011;Wicksgtrom et al., 2011;Yurchenco, 2011). This serves to reinforce the fundamental nature of these cell-ECM processes and highlights their importance to the cell biology of all metazoans.…”

Section: The Relationship Of Ecm Structure To Cell-ecm Interactions Imentioning

confidence: 96%

Components, structure, biogenesis and function of the Hydra extracellular matrix in regeneration, pattern formation and cell differentiation

Sarras

2012

Int. J. Dev. Biol.

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The body wall of Hydra is organized as an epithelial bilayer (ectoderm and endoderm) with an intervening extracellular matrix (ECM), termed mesoglea by early biologists. Morphological studies have determined that Hydra ECM is composed of two basal lamina layers positioned at the base of each epithelial layer with an intervening interstitial matrix. Molecular and biochemical analyses of Hydra ECM have established that it contains components similar to those seen in more complicated vertebrate species. These components include such macromolecules as laminin, type IV collagen, and various fibrillar collagens. These components are synthesized in a complicated manner involving cross-talk between the epithelial bilayer. Any perturbation to ECM biogenesis leads to a blockage in Hydra morphogenesis. Blockage in ECM/cell interactions in the adult polyp also leads to problems in epithelial transdifferentiation processes. In terms of biophysical parameters, Hydra ECM is highly flexible; a property that facilitates continuous movements along the organism's longitudinal and radial axis. This is in contrast to the more rigid matrices often found in vertebrates. The flexible nature of Hydra ECM can in part now be explained by the unique structure of the organism's type IV collagen and fibrillar collagens. This review will focus on Hydra ECM in regard to: 1) its general structure, 2) its molecular composition, 3) the biophysical basis for the flexible nature of Hydra's ECM, 4) the relationship of the biogenesis of Hydra ECM to regeneration of body form, and 5) the functional role of Hydra ECM during pattern formation and cell differentiation.

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“…The formation of basement membrane is indispensable for normal tissue development and function (Smyth et al, 1999;Miner and Yurchenco, 2004). BM regulates diferent biological activities, like development, proliferation, diferentiation, growth, migration of cells, cell polarity, adhesion, among others (Erickson and Couchman, 2000;Kruegel and Miosge, 2010). Histological analysis suggests that the migration and adhesion of cells might be interfered in Ric-8 À/À embryos and the morphogenesis impaired.…”

Section: Ric-8 2/2 Embryos Are Not Competent In Organogenesismentioning

confidence: 99%

Nucleotide exchange factor RIC‐8 is indispensable in mammalian early development

Tõnissoo¹,

Lulla²,

Meier³

et al. 2010

Developmental Dynamics

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The guanine nucleotide exchange factor RIC-8 is a conserved protein essential for the asymmetric division in the early embryogenesis in different organisms. The function of RIC-8 in mammalian development is not characterized so far. In this study we map the expression of RIC-8 during the early development of mouse. To elucidate the RIC-8 function we used Ric-8 2/2 mutant embryos. The Ric-8 2/2 embryos reach the gastrulation stage but do not develop further and die at E6.5-E8.5. We characterized the Ric-8 2/2 embryonic phenotype by morphological and marker gene analyses. The gastrulation is initiated in Ric-8 2/2 embryos but their growth is retarded, epiblast and mesoderm disorganized. Additionally, the basement membrane is defective, amnion folding and the formation of allantois are interfered, also the cavitation. Furthermore, the orientation of the Ric-8 2/2 embryo in the uterus was abnormal. Our study reveals that the activity of RIC-8 protein is irreplaceable for the correct gastrulation of mouse embryo. Developmental Dynamics 239:3404-3415,

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Basement membrane components are key players in specialized extracellular matrices

Cited by 206 publications

References 194 publications

Nidogen-1 is a novel extracellular ligand for the NKp44 activating receptor

Nidogen-1 is a novel extracellular ligand for the NKp44 activating receptor

Components, structure, biogenesis and function of the Hydra extracellular matrix in regeneration, pattern formation and cell differentiation

Nucleotide exchange factor RIC‐8 is indispensable in mammalian early development

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