Baseline tubular biomarkers in young adults with congenital heart disease as compared to healthy young adults: Detecting subclinical kidney injury

Fuhrman, Dana Y.; Nguyen, Lan; Hindes, Morgan; Kellum, John A.

doi:10.1111/chd.12862

Cited by 7 publications

(6 citation statements)

References 22 publications

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“…Prior to a planned exposure associated with increased AKI risk, ascertainment of kidney fitness using traditional measures of kidney function and damage, including serum creatinine and cystatin C levels, and urine albumin or protein level can be used to direct comprehensive kidney protection and surveillance and prevent AKI development . Preoperative values of candidate biomarkers may have utility in predicting AKI after cardiac surgery in adults and children . Kidney functional reserve values can predict postoperative AKI in adults .…”

Section: Methodsmentioning

confidence: 99%

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Consensus-Based Recommendations on Priority Activities to Address Acute Kidney Injury in Children

et al. 2022

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ImportanceIncreasing evidence indicates that acute kidney injury (AKI) occurs frequently in children and young adults and is associated with poor short-term and long-term outcomes. Guidance is required to focus efforts related to expansion of pediatric AKI knowledge.ObjectiveTo develop expert-driven pediatric specific recommendations on needed AKI research, education, practice, and advocacy.Evidence ReviewAt the 26th Acute Disease Quality Initiative meeting conducted in November 2021 by 47 multiprofessional international experts in general pediatrics, nephrology, and critical care, the panel focused on 6 areas: (1) epidemiology; (2) diagnostics; (3) fluid overload; (4) kidney support therapies; (5) biology, pharmacology, and nutrition; and (6) education and advocacy. An objective scientific review and distillation of literature through September 2021 was performed of (1) epidemiology, (2) risk assessment and diagnosis, (3) fluid assessment, (4) kidney support and extracorporeal therapies, (5) pathobiology, nutrition, and pharmacology, and (6) education and advocacy. Using an established modified Delphi process based on existing data, workgroups derived consensus statements with recommendations.FindingsThe meeting developed 12 consensus statements and 29 research recommendations. Principal suggestions were to address gaps of knowledge by including data from varying socioeconomic groups, broadening definition of AKI phenotypes, adjudicating fluid balance by disease severity, integrating biopathology of child growth and development, and partnering with families and communities in AKI advocacy.Conclusions and RelevanceExisting evidence across observational study supports further efforts to increase knowledge related to AKI in childhood. Significant gaps of knowledge may be addressed by focused efforts.

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Section: Methodsmentioning

confidence: 99%

“…32 Preoperative values of candidate biomarkers may have utility in predicting AKI after cardiac surgery in adults and children. [33][34][35] Kidney functional reserve values can predict postoperative AKI in adults. 36 (Figure 1A 31 ).…”

Section: Jama Network Open | Pediatricsmentioning

confidence: 99%

Consensus-Based Recommendations on Priority Activities to Address Acute Kidney Injury in Children

et al. 2022

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“…These biomarkers could potentially be used to detect early tubular injury before abnormalities in traditional biomarkers of kidney dysfunction are apparent. (Fuhrman et al, 2019) The identification of more accurate and sensitive diagnostic tools and biomarkers of kidney function is currently a research priority. Further studies that include younger patients with CHD are needed as currently used biomarkers were primarily validated in adult patients.…”

Section: Assessment Of Kidney Disease In Adult Congenital Heart Diseasementioning

confidence: 99%

Kidney disease and congenital heart disease: Partnership for life

et al. 2022

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The literature on the relationship between kidney and cardiovascular diseases is continuously expanding. Scientists have elucidated many of the neurohormonal and hemodynamic pathways involved in cardiorenal disease. However, little is known about kidney disease in patients with congenital heart disease. Given advances in the medical and surgical care of this highly complex patient population, survival rates have dramatically improved leading to a higher percentage of adults living with congenital heart disease. Accordingly, a noticeable increase in the prevalence of kidney disease is appreciated in these patients. Some of the main risk factors for developing chronic kidney disease in the adult congenital heart disease population include chronic hypoxia, neurohormonal derangements, intraglomerular hemodynamic changes, prior cardiac surgeries from minimally invasive to open heart surgeries with ischemia, and nephrotoxins. Unfortunately, data regarding the prevalence, pathophysiology, and prognosis of chronic kidney disease in the adult congenital heart disease population remain scarce. This has led to a lack of clear recommendations for evaluating and managing kidney disease in these patients. In this review, we discuss contemporary data on kidney disease in adults with congenital heart disease in addition to some of the gaps in knowledge we face. The article highlights the delicate interaction between disease of the heart and kidneys in these patients, and offers the practitioner tools to more effectively manage this vulnerable population.

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“…IGFBP-7 has been identified as a potential biomarker for adverse outcome in acquired heart failure patients [26], and is associated with diastolic dysfunction and lower VO 2 max [42]. In ConHD patients, the role of IGFPBs in cardiac function or prognosis is largely unexplored, but has been linked to general growth, failure to thrive, nutritional status and subclinical kidney injury [45][46][47].…”

Section: Igfbp-7mentioning

confidence: 99%

Associations between blood biomarkers, cardiac function and adverse outcome in a young tetralogy of Fallot cohort

Bosch

Genuchten

Luijnenburg

et al. 2022

International Journal of Cardiology

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Baseline tubular biomarkers in young adults with congenital heart disease as compared to healthy young adults: Detecting subclinical kidney injury

Cited by 7 publications

References 22 publications

Consensus-Based Recommendations on Priority Activities to Address Acute Kidney Injury in Children

Consensus-Based Recommendations on Priority Activities to Address Acute Kidney Injury in Children

Kidney disease and congenital heart disease: Partnership for life

Associations between blood biomarkers, cardiac function and adverse outcome in a young tetralogy of Fallot cohort

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