Baseline social amotivation predicts 1-year functioning in UHR subjects: A validation and prospective investigation

Lam, Max; Rashid, Nur Amirah Abdul; Lee, Sara-Ann; Lim, Jeanette; Foussias, George; Fervaha, Gagan; Ruhrman, S.; Remington, Gary; Lee, Jimmy

doi:10.1016/j.euroneuro.2015.10.007

Cited by 19 publications

(15 citation statements)

References 71 publications

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“…Five studies examined associations between psychopathological dimensions and transition (Demjaha et al, ; M. Lam et al, ; Morcillo et al, ; Rietdijk et al, ; Valmaggia et al, ). Three studies explored the presence of psychiatric comorbidities and their associations with clinical and functional outcomes in subjects at UHR (Fusar‐Poli et al, ; Lim et al, ; Rutigliano et al, ).…”

Section: Resultsmentioning

confidence: 99%

Early intervention for everyone? A review of cross‐cultural issues and their treatment in ultra‐high‐risk (UHR) cohorts

Deriu

Moro

Benoit

2018

Early Intervention Psych

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This systematic review demonstrates barriers to the access to participation in early intervention research for migrants and ethnic minorities. This selection bias may result in lower validity for the CAARMS among these populations and thus in inadequate intervention programmes. Along with targeted studies, minorities' access to participation in UHR cohorts should be improved through 3 tools: interpreters at recruitment and for administration of CAARMS, a guide to cultural formulation and transcultural data collection.

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Section: Resultsmentioning

confidence: 99%

Early intervention for everyone? A review of cross‐cultural issues and their treatment in ultra‐high‐risk (UHR) cohorts

Deriu

Moro

Benoit

2018

Early Intervention Psych

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“…Psychopathology was assessed using Positive and Negative Syndrome Scale (PANSS) [32] and Calgary Depression Scale (CDS) [33]. Measurement of negative symptoms was divided into two distinct sub-domains, i.e., amotivation and DE scores using PANSS based on previous factor-analytic studies [12,34]. Amotivation score was derived by summing the PANSS items N2 (emotional withdrawal), N4 (passive social withdrawal) and G16 (active social avoidance), while DE score was the sum of items N1 (blunted affect), N3 (poor rapport), N6 (lack of spontaneity) and G7 (motor retardation).…”

Section: Methodsmentioning

confidence: 99%

Prediction of motivational impairment: 12-month follow-up of the randomized-controlled trial on extended early intervention for first-episode psychosis

et al. 2017

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BackgroundAmotivation is prevalent in first-episode psychosis (FEP) patients and is a major determinant of functional outcome. Prediction of amotivation in the early stage of psychosis, however, is under-studied. We aimed to prospectively examine predictors of amotivation in FEP patients in a randomized-controlled trial comparing a 1-year extension of early intervention (Extended EI, 3-year EI) with step-down psychiatric care (SC, 2-year EI).MethodsOne hundred sixty Chinese patents were recruited from a specialized EI program for FEP in Hong Kong after they have completed this 2-year EI service, randomly allocated to Extended EI or SC, and followed up for 12 months. Assessments on premorbid adjustment, onset profiles, baseline symptom severity and treatment characteristics were conducted. Data analysis was based on 156 subjects who completed follow-up assessments.ResultsAmotivation at 12-month follow-up was associated with premorbid adjustment, allocated treatment condition, and levels of positive symptoms, disorganization, amotivation, diminished expression (DE) and depression at study intake. Hierarchical multiple regression analysis revealed that Extended EI and lower levels of DE independently predicted better outcome on 12-month amotivation.ConclusionOur findings indicate a potentially critical therapeutic role of an extended specialized EI on alleviating motivational impairment in FEP patients. The longer-term effect of Extended EI on amotivation merits further investigation.

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“…Corcoran et al () established an impact of negative, disorganized, depressive and general symptoms on social functioning in CHR, with negative symptoms showing the strongest correlations. Lam et al () confirmed a prospective predictive relationship between social amotivation and functional outcomes, but did not examine cognitive factors; several others confirmed similar effects in cross‐sectional studies (eg, Kim et al, ; see Cotter et al, for a review). Niendam et al () found an association between negative symptoms and functioning, as well as correlations between two specific cognitive measures (reasoning and verbal learning) and functioning.…”

Section: Introductionmentioning

confidence: 98%

Negative symptoms in the clinical high‐risk state for psychosis: Connection with cognition and primacy in impacting functioning

Gerritsen

Lepock

Ahmed

et al. 2019

Early Intervention Psych

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Aim In the clinical high‐risk (CHR) state for psychosis, both negative symptoms and lower cognitive function have been associated with poorer daily functioning. Recent evidence suggests that negative symptoms share overlapping variability with cognition and may partially mediate the relationship between cognition and functioning. However, the nature of this overlap is unknown, and the reverse mediation model remains untested leaving the precise nature of these associations unclear. Methods In order to clarify these relationships, a sample of community‐dwelling youth meeting CHR criteria was collected from a specialty CHR clinic (n = 91, mean age = 21, 63% male). Bootstrapping methods were then applied in a mediation analysis to test both negative symptoms and cognition as independent variables and mediating variables predicting social and role functioning in CHR individuals. Canonical correlation analysis was used to characterize the overlapping variability between negative symptoms and cognition. Results Support for a primary role of negative symptoms in predicting functioning and cognition was observed. Canonical correlation revealed a single dimension of overlap between the two symptom types (r = .62), represented by a strong correlation between negative symptoms in general and tasks involving verbal working memory, vigilance and social cognition specifically. A single cognitive factor composed primarily of these tasks was found to predict role functioning (adjusted R 2 = .04). Conclusions The results highlight the importance of considering specific cognitive mechanisms overlapping with negative symptoms in research and rehabilitative practice in CHR populations, as well as the primary importance of targeting negative symptoms.

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Baseline social amotivation predicts 1-year functioning in UHR subjects: A validation and prospective investigation

Cited by 19 publications

References 71 publications

Early intervention for everyone? A review of cross‐cultural issues and their treatment in ultra‐high‐risk (UHR) cohorts

Early intervention for everyone? A review of cross‐cultural issues and their treatment in ultra‐high‐risk (UHR) cohorts

Prediction of motivational impairment: 12-month follow-up of the randomized-controlled trial on extended early intervention for first-episode psychosis

Negative symptoms in the clinical high‐risk state for psychosis: Connection with cognition and primacy in impacting functioning

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