Baseline Quality-of-Life of Caregivers of Patients With Heart Failure Prior to Advanced Therapies: Findings From the Sustaining Quality of Life of the Aged: Transplant or Mechanical Support (SUSTAIN-IT) Study

Petty, Michael; Wu, Tingqing; Andrei, AC; Baldridge, Abigail S.; Warzecha, Anna; A, Kao; Spertus, John A.; Hsich, Eileen; Ma, Dew; Pham, Duc Thinh; Yancy, Clyde W.; Hartupee, Justin; Cotts, William; Pamboukian, SV; Pagani, Francis D.; Lampert, Brent C.; Johnson, Maryl R.; Murray, Margaret; Tekeda, K; Yuzefpolskaya, M.; Silvestry, Scott C.; Kirklin, JK; KL, Grady

doi:10.1016/j.cardfail.2022.03.358

Cited by 2 publications

(2 citation statements)

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“…Sustaining Quality of Life of the Aged: Heart Transplant or Mechanical Support (SUSTAIN-IT) is a National Institute on Aging–funded study of patients with heart failure aged 60 to 80 years who undergo heart transplantation or long-term LVAD implantation, when ineligible for transplant, and their caregivers 23 . Patient and caregiver inclusion and exclusion criteria for SUSTAIN-IT have been described previously 24,25 . For this report from SUSTAIN-IT, patients with advanced heart failure were included if they were scheduled to undergo long-term LVAD implantation with a second- or third-generation Food and Drug Administration–approved or investigational LVAD 23 .…”

Section: Methodsmentioning

confidence: 99%

“…23 Patient and caregiver inclusion and exclusion criteria for SUSTAIN-IT have been described previously. 24,25 For this report from SUSTAIN-IT, patients with advanced heart failure were included if they were scheduled to undergo long-term LVAD implantation with a second-or third-generation Food and Drug Administration-approved or investigational LVAD. 23 Long-term LVAD implant was defined as not listed for heart transplantation at the time of implantation and having a low probability of transplant (<35% at 2 years) in the site investigator's opinion.…”

Section: Study Populationmentioning

confidence: 99%

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Association Between Caregiver Burden and Patient Recovery After Left Ventricular Assist Device Implantation

et al. 2023

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Introduction: After left ventricular assist device (LVAD) implantation, caregivers may experience increasing burden because of new roles and responsibilities. We examined the association between caregiver burden at baseline and patient recovery after long-term LVAD implantation in patients ineligible for heart transplantation. Methods: Between October 1, 2015, and December 31, 2018, data from 60 patients with a long-term LVAD (age, 60-80 years) and caregivers through 1 postoperative year were analyzed. Caregiver burden was measured using the Oberst Caregiving Burden Scale, a validated instrument used for measuring caregiver burden. Patient recovery post-LVAD implantation was defined by change in Kansas City Cardiomyopathy Questionnaire-12 (KCCQ-12) overall summary score and rehospitalizations over 1 year. Multivariable regression models (least-squares for change in KCCQ-12 and Fine-Gray cumulative incidence for rehospitalizations) were used to assess for association with caregiver burden. Results: Patients were 69.4 ± 5.5 years old, 85% men, and 90% White. Over the first year post-LVAD implantation, there was a 32% cumulative probability of rehospitalization; 72% (43/60) of patients had an improvement of ≥5 points in KCCQ-12 scores. Caregivers were 61.2 ± 11.5 years old, 93% women, 81% White, and 85% married. Median Oberst Caregiving Burden Scale Difficulty and Time scores at baseline were 1.13 and 2.27, respectively. Higher caregiver burden was not significantly associated with hospitalizations or change in patient health-related quality of life during the first year post-LVAD implantation. Conclusions: Higher caregiver burden at baseline was not associated with patient recovery in the first year after LVAD implantation. Understanding the associations between caregiver burden and patient outcomes after LVAD implantation is important as excessive caregiver burden is a relative contraindication for LVAD implantation.

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Section: Methodsmentioning

confidence: 99%