Baseline Plasma Levels of Interleukin-8 in Stage IV Non-Small-Cell Lung Cancer Patients: Relationship With Nutritional Status and Prognosis

Gioulbasanis, Ioannis; Patrikidou, Anna; Kitikidou, Kyriaki; Papadimitriou, Konstantinos; Vlachostergios, Panagiotis J.; Tsatsanis, Christos; Margioris, Andrew N.; Papandreou, Christos N.; Mavroudis, Dimitris; Georgoulias, Vassilis

doi:10.1080/01635581.2012.630157

Cited by 20 publications

(21 citation statements)

References 30 publications

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“…Therefore, the development of potential biomarkers for these tumors is an urgent unmet need. We also observed that patients with higher IL8 levels presented decreased survival, in accordance with previous reports (25)(26)(27)29,31,(42)(43)(44). Although this fact may be explained by tumor burden, a contribution by a direct pathogenic role of IL8 cannot be excluded, because IL8 is involved in tumor vascularization (5,45) and chemotactically disorients migration of immune cells (12).…”

Section: Discussionsupporting

confidence: 79%

Serum Interleukin-8 Reflects Tumor Burden and Treatment Response across Malignancies of Multiple Tissue Origins

Sanmamed

Carranza-Rua

Alfaro

et al. 2014

Clinical Cancer Research

210

158

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Purpose: Interleukin-8 (IL8) is a chemokine produced by malignant cells of multiple cancer types. It exerts various functions in shaping protumoral vascularization and inflammation/immunity. We evaluated sequential levels of serum IL8 in preclinical tumor models and in patients to assess its ability to estimate tumor burden.Experimental Design: IL8 levels were monitored by sandwich ELISAs in cultured tumor cells supernatants, tumor-xenografted mice serum, and in samples from 126 patients with cancer. We correlated IL8 serum levels with baseline tumor burden and with treatment-induced changes in tumor burden, as well as with prognosis.Results: IL8 concentrations correlated with the number of IL8-producing tumor cells in culture. In xenografted neoplasms, IL8 serum levels rapidly dropped after surgical excision, indicating an accurate correlation with tumor burden. In patients with melanoma (n ¼ 16), renal cell carcinoma (RCC; n ¼ 23), non-small cell lung cancer (NSCLC; n ¼ 21), or hepatocellular carcinoma (HCC; n ¼ 30), serum IL8 concentrations correlated with tumor burden and stage, survival (melanoma, n ¼ 16; RCC, n ¼ 23; HCC, n ¼ 33), and objective responses to therapy, including those to BRAF inhibitors (melanoma, n ¼ 16) and immunomodulatory monoclonal antibodies (melanoma, n ¼ 8). IL8 concentrations in urine (n ¼ 18) were mainly elevated in tumors with direct contact with the urinary tract.Conclusions: IL8 levels correlate with tumor burden in preclinical models and in patients with cancer.

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Section: Discussionsupporting

confidence: 79%

Serum Interleukin-8 Reflects Tumor Burden and Treatment Response across Malignancies of Multiple Tissue Origins

Sanmamed

Carranza-Rua

Alfaro

et al. 2014

Clinical Cancer Research

210

158

View full text Add to dashboard Cite

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“…It is also known that high level of cytokines TNFα, IL-6, and IL-2 are associated with a decrease in food intake and may contribute to anorexia. Other studies have demonstrated the relationship between malnutrition and inflammatory markers in specific population groups, including in children [24,25], dialysis patients [14,15,18,[26][27][28][29][30], patients with neoplasms [19,31,32], and patients with autoimmune diseases [33,34].…”

Section: Discussionmentioning

confidence: 99%

“…Nonetheless, there is an evidence of a relationship between malnutrition and inflammation expressed by elevated levels of pro-inflammatory cytokines and these biomarkers were independent risk factors of malnutrition in various disease states, such as renal failure [18], neoplastic disease [19], and Alzheimer's disease [20].…”

Section: Introductionmentioning

confidence: 99%

The relationship between malnutrition risk and inflammatory biomarkers in outpatient geriatric population

et al. 2020

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Aim It is crucial to identify factors contributing to malnutrition risk in older persons in order to prevent malnutrition as far as possible. Findings Factors that increased the risk of malnutrition were: increased levels of IL-8, osteoprotegerin (OPG), and Soluble-Receptor-For-TNF-alfa (sTNFRII; log transformed). In comparison with previous studies, in our study there was no significant difference in hsCRP and IL-6 in participants at risk of malnutrition and those who were well-nourished, nevertheless, those at risk of malnutrition had significantly higher IL-8, OPG and sTNFRII concentrations, but higher levels of IL-18. Message The etiopathogenesis of malnutrition in older persons is complex and our study indicated that chronic inflammation plays a probable role and should be considered in evaluating nutritional status in the geriatric population; however, it also exposes an avenue where further research is needed in order to enhance our understanding and guide comprehensive patient care.

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“…Consistent with international consensus for cachexia diagnosis, our results demonstrate systemic inflammation in cancer cachectic vs. non-cachectic patients, with increased circulating CRP, IL6, TNFα, IL8, and IL5 levels. A previous study reported that high plasma concentrations of IL8 in patients with advanced lung cancer (stage IV), were correlated with cachexia [51]. On the other hand, increased circulating levels of IL8 are also reported as markers in patients with pulmonary fibrosis [52].…”

Section: Discussionmentioning

confidence: 99%

Adipose tissue fibrosis in human cancer cachexia: the role of TGFβ pathway

et al. 2017

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BackgroundCancer cachexia is a multifactorial syndrome that dramatically decreases survival. Loss of white adipose tissue (WAT) is one of the key characteristics of cachexia. WAT wasting is paralleled by microarchitectural remodeling in cachectic cancer patients. Fibrosis results from uncontrolled ECM synthesis, a process in which, transforming growth factor-beta (TGFβ) plays a pivotal role. So far, the mechanisms involved in adipose tissue (AT) re-arrangement, and the role of TGFβ in inducing AT remodeling in weight-losing cancer patients are poorly understood. This study examined the modulation of ECM components mediated by TGFβ pathway in fibrotic AT obtained from cachectic gastrointestinal cancer patients.MethodsAfter signing the informed consent form, patients were enrolled into the following groups: cancer cachexia (CC, n = 21), weight-stable cancer (WSC, n = 17), and control (n = 21). The total amount of collagen and elastic fibers in the subcutaneous AT was assessed by histological analysis and by immunohistochemistry. TGFβ isoforms expression was analyzed by Multiplex assay and by immunohistochemistry. Alpha-smooth muscle actin (αSMA), fibroblast-specific protein (FSP1), Smad3 and 4 were quantified by qPCR and/or by immunohistochemistry. Interleukin (IL) 2, IL5, IL8, IL13 and IL17 content, cytokines known to be associated with fibrosis, was measured by Multiplex assay.ResultsThere was an accumulation of collagen and elastic fibers in the AT of CC, as compared with WSC and controls. Collagens type I, III, VI, and fibronectin expression was enhanced in the tissue of CC, compared with both WSC and control. The pronounced expression of αSMA in the surrounding of adipocytes, and the increased mRNA content for FSP1 (20-fold) indicate the presence of activated myofibroblasts; particularly in CC. TGFβ1 and TGFβ3 levels were up-regulated by cachexia in AT, as well in the isolated adipocytes. Smad3 and Smad4 labeling was found to be more evident in the fibrotic areas of CC adipose tissue.ConclusionsCancer cachexia promotes the development of AT fibrosis, in association with altered TGFβ signaling, compromising AT organization and function.

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Baseline Plasma Levels of Interleukin-8 in Stage IV Non-Small-Cell Lung Cancer Patients: Relationship With Nutritional Status and Prognosis

Cited by 20 publications

References 30 publications

Serum Interleukin-8 Reflects Tumor Burden and Treatment Response across Malignancies of Multiple Tissue Origins

Serum Interleukin-8 Reflects Tumor Burden and Treatment Response across Malignancies of Multiple Tissue Origins

The relationship between malnutrition risk and inflammatory biomarkers in outpatient geriatric population

Adipose tissue fibrosis in human cancer cachexia: the role of TGFβ pathway

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