Baseline patient reported outcomes data shows high prevalence of overactive bladder, sexual dysfunction, depression and anxiety in Canadian men with newly diagnosed localized prostate cancer

Yao, Henry Han‐I; Crump, R. Trafford; Charbonneau, Camille; Khan, Asher; Barton, Carly; Brotherhood, Hilary; Jiang, Jing; Carlson, Kevin; Baverstock, Richard

doi:10.21037/tau-20-689

Cited by 8 publications

(8 citation statements)

References 33 publications

(37 reference statements)

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“…Although less frequently studied, other LUTS are not uncommon after RP [ 5 ]. Unfortunately, the high preoperative incidence of LUTS further complicates research on the impact of surgery on lower urinary tract (LUT) function afterwards [ 6 , 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

De Novo Detrusor Underactivity and Other Urodynamic Findings after Radical Prostatectomy: A Systematic Review

et al. 2022

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Background and objectives: The aim of this systematic review is to evaluate the impact of radical prostatectomy (RP) on bladder function, with special attention towards detrusor underactivity investigated with the means of urodynamic evaluation. Materials and Methods: The review was performed in accordance with the PRISMA statement and was registered in the PROSPERO (ID#: CRD42020223480). The studied population was limited to men with prostate cancer who underwent urodynamic study prior to and after radical prostatectomy. Eight hundred twenty-seven studies were screened, with twenty-five finally included. A qualitative analysis was performed. Rates of detrusor underactivity (DU) before surgery were reported in eight studies and ranged from 1.6% to 75% (median of 40.8%). DU occurred de novo after RP in 9.1% to 37% of patients (median of 29.1%). On the other hand, preexisting DU resolved in 7% to 35.5% of affected men. Detrusor overactivity (DO) was the most frequently reported outcome, being assessed in 23 studies. The rate of DO preoperatively was from 5% to 76% (median of 25%). De novo was reported in 2.3–54.4% of patients (median of 15%) and resolved after RP in 19.6% to 87.5% (median of 33%) of affected patients. Baseline rates of bladder outlet obstruction (BOO) varied between studies from 19% to 59.3%, with a median of 27.8%. The most pronounced change after surgery was the resolution of BOO in 88% to 93.8% (median of 92%) of affected patients. Results: Rates of de novo impaired bladder compliance (IBC) varied from 3.2% to 41.3% (median of 13.3%), whereas the resolution of IBC was reported with rates ranging from 0% to 47% (median of 4.8%). Conclusions: BOO, DO, and DU are frequently diagnosed in men scheduled for RP. BOO is improved after RP in most patients; however, there is still a substantial rate of patients with de novo DU as well as DO which may impair functional outcomes and quality of life.

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Section: Introductionmentioning

confidence: 99%

De Novo Detrusor Underactivity and Other Urodynamic Findings after Radical Prostatectomy: A Systematic Review

et al. 2022

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“…5 Research has previously shown the rate of overactive bladder (OAB) to be 55.8% in men with newly diagnosed prostate cancer. 6 Men with LUTS due to benign prostate hyperplasia (BPH) are more likely to seek medical attention, undergo investigations, and be diagnosed with prostate cancer. 7,8 It is important to address both LUTS and prostate cancer in wholistic patient management.…”

Section: Introductionmentioning

confidence: 99%

Impact of radical prostatectomy on bladder function as demonstrated on urodynamics study—A systematic review

Yao

Hoe

Crump

et al. 2021

Neurourology and Urodynamics

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Aims: This study aims to describe the effects of radical prostatectomy (RP) on bladder function by performing a systematic review of urodynamics study findings before and after RP. Methods: This systematic review was conducted in accordance with the PRISMA guideline and registered on PROSPERO (CRD42020206844). A systematic search was conducted using PubMed, Cochrane, and Embase. Studies were included if they involved men who underwent RP and had urodynamics study performed preoperatively, postoperatively, or both. Studies that included only subgroups of patients based on symptoms were excluded. Three hundred and four articles were screened, with 20 articles included. A qualitative analysis was performed. Results: The rate of baseline bladder outlet obstruction (BOO) pre-RP was 19%-67%. All six studies with comparative data pre-and postoperatively demonstrated a decrease in the rate of patients with equivocal or clear obstruction. The baseline rates of detrusor overactivity (DO) varied widely from 11% to 61.2%. Six of eight studies with 6 months or more follow-up showed an improvement in the rates of DO ranging from 3.0% to 12.5%. The rate of de novo DO ranged from 0% to 54.5%. Four studies reported an increased rate of impaired bladder contractility and two of three studies showed a worsening rate of impaired bladder compliance following RP. This review is limited by the absence of level I/II studies. Conclusions: Urodynamics study shows that BOO is improved following RP in most patients. RP resolves DO in some patients and cause de novo DO in others. The net effect is a reduced overall rate of DO in most studies. Bladder compliance and contractility may be impaired after RP.

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“…26 We observed lower urinary and bowel functional domain scores in men reporting higher problems with feeling depressed and lack of energy. While we are uncertain of causality, it is known that poor urinary symptoms following treatment are associated with poorer patient reported outcomes in terms of overall quality of life, 27,28 depression, 29 regret over treatment decisions, 30 sexual functioning, 31,32 34 Further, the use of a single question within a larger tool has been shown to be clinically useful in patients with cancer. 35 A single question of the Edmonton Symptom Assessment System (where the patient answers on a one to 10 ordinal scale from not depressed to worst possible depression) demonstrated acceptable performance in screening of depression detected by the HADS 36 or the depression subscale of the PHQ-9.…”

Section: Discussionmentioning

confidence: 99%

“…We observed lower urinary and bowel functional domain scores in men reporting higher problems with feeling depressed and lack of energy. While we are uncertain of causality, it is known that poor urinary symptoms following treatment are associated with poorer patient reported outcomes in terms of overall quality of life, 27,28 depression, 29 regret over treatment decisions, 30 sexual functioning, 31,32 and relationship quality 33 …”

Section: Discussionmentioning

confidence: 99%

Self‐reported lack of energy or feeling depressed 12 months after treatment in men diagnosed with prostate cancer within a population‐based registry

et al. 2021

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Objective: Feeling depressed and lethargic are common side effects of prostate cancer (PCa) and its treatments. We examined the incidence and severity of feeling depressed and lack of energy in patients in a population based PCa registry. Methods:We included men diagnosed with PCa between 2015 and 2019 in Victoria, Australia, and enrolled in the Prostate Cancer Outcomes Registry. The primary outcome measures were responses to two questions on the Expanded Prostate Cancer Index Composite (EPIC-26) patient reported instrument: problems with feeling depressed and problems with lack of energy 12 months following treatment. We evaluated associations between these and age, cancer risk category, treatment type, and urinary, bowel, and sexual function.

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Baseline patient reported outcomes data shows high prevalence of overactive bladder, sexual dysfunction, depression and anxiety in Canadian men with newly diagnosed localized prostate cancer

Cited by 8 publications

References 33 publications

De Novo Detrusor Underactivity and Other Urodynamic Findings after Radical Prostatectomy: A Systematic Review

De Novo Detrusor Underactivity and Other Urodynamic Findings after Radical Prostatectomy: A Systematic Review

Impact of radical prostatectomy on bladder function as demonstrated on urodynamics study—A systematic review

Self‐reported lack of energy or feeling depressed 12 months after treatment in men diagnosed with prostate cancer within a population‐based registry

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