Baseline Features of Idiopathic Optic Neuritis as Determined by a Multicenter Treatment Trial in Japan

Wakakura, Masato; Minei-Higa, Risako; Oono, Shinji; Matsui, Yoshie; Tabuchi, Akio; Kani, Kazutaka; Shikishima, Keigo; Kawai, Kazushige; Nakao, Yosuke; Tazawa, Yutaka; Kiyosawa, Motohiro; Abe, Haruki; Ohba, Norio; Yago, Keiko; Maeda, Shogo; Sugita, Minoru; Ishikawa, Satoshi

doi:10.1016/s0021-5155(98)00072-0

Cited by 105 publications

(96 citation statements)

References 10 publications

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“…[14][15][16] In Asia, ON is proportionately more common relative to the incidence of MS in the United States of America or Western Europe. 17 ON is less frequent in South America and in the Mediterranean region but newer studies have reported an increasing prevalence in the last few decades. [18][19][20] Some studies have shown that individuals who migrate before puberty have the incidence of MS in the area to which they have migrated.…”

Section: Epidemiologymentioning

confidence: 99%

Optic neuritis

Pau

Al‐Zubidi

Yalamanchili

et al. 2011

Eye

126

115

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Aims The aim of this study is to provide a clinical update on optic neuritis (ON), its association with multiple sclerosis (MS), and neuromyelitis optica (NMO). Methods This study included a PubMed review of the literature written in the English language.Results ON in adults is typically idiopathic or demyelinating, and is characterised by unilateral, subacute, painful loss of vision that is not associated with any systemic or other neurological symptoms. Demyelinating ON is associated with MS, and we review the key studies of ON including the ON treatment trial and several other MS treatment trials and NMO. Conclusion Acute demyelinating ON can occur in isolation or be associated with MS. Typical ON does not require additional evaluation other than cranial magnetic resonance imaging. NMO is likely a separate disorder from MS and the ON in NMO has a different treatment and prognosis. Methodology The authors conducted an English language search using Pubmed from the years 1964 to 2010 using the search terms 'ON', 'MS' and 'NMO'. The authors included original articles, review articles, and case reports, which revealed new aspects as far as epidemiology, histopathology, clinical manifestations, imaging, genetics, and treatment of ON. Titles were reviewed for topicality and full references were obtained. Letters to the editor, unpublished work, and abstracts were not included in this review.

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Section: Epidemiologymentioning

confidence: 99%

Optic neuritis

Pau

Al‐Zubidi

Yalamanchili

et al. 2011

Eye

126

115

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“…Alternative causes of ON, and some other clinical entities that can cause acute or subacute visual disturbances and mimic demyelinating optic neuritis, require consideration if a patient with presumed ON does not follow the typical clinical course 1,5 . Although there are some published studies concerning optic neuritis in Asian countries [6][7][8][9] , there are very few English-language reports about optic neuritis in China [10][11] . In the present study, a group of patients that had been referred with the presumptive diagnosis of ON was carefully re-evaluated with the goals of determining the spectrum of diagnoses in China and comparing then with reports from western countries.…”

Section: Introductionmentioning

confidence: 99%

Etiological profile of presumptive optic neuritis in China

Zhang

Wang

Wei

et al. 2008

Journal of Clinical Neuroscience

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Objective: To determine the diagnoses in a population of patients with presumed optic neuritis in China and compare the spectrum of etiologies with those in western countries. Methods: We studied a group of 204 patients referred with a presumptive diagnosis of optic neuritis (ON) to a teaching hospital. We conducted detailed medical and family history, thorough ophthalmologic and neurological examinations, and laboratory tests including neuroimaging. Patients were diagnosed using international diagnostic criteria.Results: 113 cases (55.4%) met ON criteria, among which 83 cases (73.5%) were considered as idiopathic demyelinating optic neuritis (IDON). Brain MRI white matter lesions were found in 11 of 78 (14.1%) clinically "isolated" IDON cases. Tuberculosis meningitis accounted for 2 cases and syphilis for 1. The cause of 26 cases (23.0%) remained uncertain, but these cases were still likely to be IDON accompanied by secondary axonal degeneration. Thirty-eight cases (18.6%) were confirmed to be Leber's hereditary optic neuropathy Etiological profile of presumptive optic neuritis in China

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“…According to previous studies, ON in Asian countries shows a higher rate of papillitis than that in Western countries. [24][25][26] As a result, an increase in Abbreviations: pRNFL, peripapillary retinal nerve fiber layer; n, number; logMAR, logarithm of the minimum angle of resolution; MD, mean deviation; GCIPL, ganglion cell-inner plexiform layer; GCL, ganglion cell layer; IPL: inner plexiform layer. a The difference was calculated by subtracting the value of the eye without optic neuritis from that of the eye with optic neuritis.…”

Section: Discussionmentioning

confidence: 99%

Retinal ganglion cell and axonal loss in optic neuritis: risk factors and visual functions

Lee

Park

et al. 2016

Eye

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Purpose The peripapillary retinal nerve fiber layer (pRNFL) and the macular ganglion cellinner plexiform layer (GCIPL) are important predictive factors for the prognosis of optic neuritis (ON). We investigated the risk factors for pRNFL and GCIPL thinning in ON and its relationship with visual function. Patients and methods We analyzed 33 eyes of 33 patients with a first attack of unilateral ON. Patients were divided into two groups according to pRNFL and GCIPL thinning, using spectral-domain optical coherence tomography. We evaluated patients' age, sex, color vision, visual acuity (VA), optic nerve findings on MRI, elapsed period from onset of visual symptoms to steroid treatment, visual field (VF) mean deviation (MD), average pRNFL thickness, and GCIPL thickness. Results There was no patient with residual VF defect in the groups without pRNFL or GCIPL thinning. Significant correlations were found between pRNFL (some sectors) and GCIPL (all sectors) thickness and BCVA and VF MD (Po0.03 for all). Multivariate logistic regression analysis revealed that only worse initial VF MD was a significant risk factor of pRFNL and GCIPL thinning after ON (OR, 0.841; 95% CI, P = 0.017 and OR, 0.871; 95% CI, P = 0.046, respectively). Conclusion Retinal ganglion cell and axonal losses occurred in ON cases showing severe initial VF loss. Therefore, it is necessary to pay more attention to the degree of initial VF loss in ON while considering the possibility of residual VF loss accompanying pRNFL and GCIPL thinning.

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Baseline Features of Idiopathic Optic Neuritis as Determined by a Multicenter Treatment Trial in Japan

Cited by 105 publications

References 10 publications

Optic neuritis

Optic neuritis

Etiological profile of presumptive optic neuritis in China

Retinal ganglion cell and axonal loss in optic neuritis: risk factors and visual functions

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