Baseline Factors Predictive of Incident Penetrating Keratoplasty in Keratoconus

Corneal collagen crosslinking in children with keratoconus

“…7,12 There is also an inverse relationship between age and risk of development of acute hydrops, as demonstrated by Suhaibani and colleagues, 13 and younger age is recognized as an independent risk factor for requiring penetrating keratoplasty in keratoconus. [14][15][16] Corneal biomechanical rigidity is weaker at a younger age 17 ; this may contribute to the severity of progression of the disease in children. Eye rubbing in conditions such as vernal keratoconjunctivitis and other allergic eye diseases may be a more significant challenge in children, both because of their increased incidence and more compulsive behavior.…”

New clinical pathways for keratoconus

“…Factors predictive of an increased risk of disease progression in keratoconus include young age (r35 years), steep keratometry, high astigmatism, reduced CDVA (irregular astigmatism), ethnicity other than white European, and documented progression in the contralateral eye. [37][38][39] These risk factors for disease progression are often present at presentation, and may be compounded if further disease progression is allowed to occur. Based on this, the proven efficacy of CXL, 14,18,19,21,22 the higher risk of CXL-related visual loss aged 435 years, 22 and the relative safety of transepithelial treatment, 33,34 we believe that there is a rational argument for transepithelial CXL at presentation for patients r35 years of age with keratometric stage II disease (Figures 2 and 3).…”

Visual Outcomes with Contact Lenses Previous Keratoplasty

“…10 Postoperative visual rehabilitation after keratoplasty usually results in wearing glasses for most patients, but to obtain the optimal vision, they need to wear contact lenses. 11 After selective suture removal following keratoplasty, contact lens fitting should be considered.…”