Baseline effective connectivity predicts response to repetitive transcranial magnetic stimulation in patients with treatment-resistant depression

Iwabuchi, Sarina J.; Auer, Dorothee P.; Lankappa, Sudheer; Palaniyappan, Lena

doi:10.1016/j.euroneuro.2019.02.012

Cited by 51 publications

(47 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, this hypothesis builds on some of the earliest neuroimaging studies in the field of psychiatry, which reported increased sgACC activity in patients during depressive episodes (85). This has been hypothesized to be causally related to reductions in lDLPFC activity (86) and reinforced by observations that antidepressant treatments lead to reductions in sgACC activity (77,79,(87)(88)(89)(90)(91)(92). For review, see Hamani et al (2011).…”

Section: Discussionmentioning

confidence: 92%

“…Early investigators concomitantly reported observations of hypometabolism and hypoperfusion in the lDLPFC of patients with MDD (72)(73)(74). Later investigators demonstrated that lDLPFC activity is restored with treatment of MDD (75)(76)(77)(78)(79)(80)(81)(82), and this early data prompted investigators to begin hypothesizing a major role of topdown dysfunction in the pathophysiology of depression (83,84).…”

Section: Discussionmentioning

confidence: 99%

“…Our results here are similar to other reports. Theta-burst rTMS stimulation of lDLPFC has been reported to reduce the magnitude of FC between lDLPFC and right insula (78) with baseline FC between these structures predicting clinical response (79). Interestingly, individuals with subthreshold depression have lower FC between DLPFC (laterality not specified) and left insula compared to non-depressed individuals (80).…”

Section: Our Assessment Of the Association Between Baseline Fc And CLmentioning

confidence: 99%

See 2 more Smart Citations

Functional connectivity changes with rapid remission from moderate-to-severe major depressive disorder

Xiao

Bentzley

Cole

et al. 2019

Preprint

View full text Add to dashboard Cite

NRW and KDS have filed intellectual property on the methodology discussed in this manuscript.Major depressive disorder is common and debilitating. It has been difficult to study the brain changes associated with recovery from depression, because treatments take weeks-to-months to become effective, and symptoms fail to resolve in many people. We recently developed a type of magnetic brain stimulation called SAINT. SAINT leads to full remission from depression in 90% of people within 5 days. We used SAINT and functional magnetic resonance imaging to determine how the brain changes with rapid remission from depression. We found changes in areas of the brain associated with emotion regulation. This provides a significantly clearer picture of how the non-depressed brain differs from the depressed brain, which can be used to develop rapid and effective treatments for depression.

show abstract

Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Our Assessment Of the Association Between Baseline Fc And CLmentioning

confidence: 99%

See 1 more Smart Citation

Functional connectivity changes with rapid remission from moderate-to-severe major depressive disorder

Xiao

Bentzley

Cole

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…A recent study by Leaver et al (2018) proposed that pretreatment connectivity measures of the DLPFC and SCC predict ECT treatment outcomes. Several studies have also reported functional connectivity changes in response to repetitive TMS (rTMS) in depressed patients (Ge et al, 2017;Kito et al, 2017;Richieri et al, 2017;Du et al, 2018;Iwabuchi et al, 2019). Positive responses to rTMS have been associated with reduced connectivity of the SCC to the DMN (Philip et al, 2018), along with reduced activity of the SCC and connectivity with the DLPFC (Hadas et al, 2019), supporting the hypothesis of altered connectivity in these areas underlying depressive symptoms (Hamilton et al, 2015).…”

Section: Examining Rapid Antidepressant Effects Through Encodingmentioning

confidence: 92%

Encoding, Consolidation, and Renormalization in Depression: Synaptic Homeostasis, Plasticity, and Sleep Integrate Rapid Antidepressant Effects

Rantamäki

Kohtala

2020

Pharmacol Rev

View full text Add to dashboard Cite

Brain and Mind Doctoral Program (S.K.), the Orion Research Foundation (S.K.), and the Emil Aaltonen foundation (S.K.). T.R. and S.K. are listed as coinventors on a patent application, wherein new tools enabling the development of rapid-acting antidepressants and the efficacy monitors thereof are disclosed based on the basic principles of ENCORE-D. T.R. and S.K. have assigned their patent rights to the University of Helsinki but will share a percentage of any royalties that may be received by the University of Helsinki.

show abstract

“…Considering the proven efficacy of iTBS for treatment of depression and speculating that the effects seen in healthy participants would extend to patients, the mechanism by which iTBS may initially influence the symptomatology of depression could be by “normalizing” the pathologically increased interaction between the SN and the DMN. In line with this reasoning, Iwabuchi et al 49 has shown in patients with depression that fronto-insular and SN connectivity interactions correlated positively with HAM-D score change at the end of a 4-week iTBS protocol. They have also described that better clinical outcomes are associated with reduced connectivity between dorsomedial prefrontal cortex (DMPFC) and bilateral insula 47 .…”

Section: Discussionmentioning

confidence: 74%

Intermittent theta burst stimulation at personalized targets reduces the functional connectivity of the default mode network in healthy subjects

Singh

Erwin-Grabner

Sutcliffe

et al. 2019

Preprint

View full text Add to dashboard Cite

20 Understanding the mechanisms by which transcranial magnetic stimulation protocols exert changes 21 in the default mode network (DMN) is paramount to develop therapeutically more effective 22 approaches in the future. A full session (3000 pulses) of 10 Hz repetitive transcranial magnetic 23 stimulation (HF-rTMS) reduces the functional connectivity (FC) of the DMN and the subgenual 24 anterior cingulate cortex but current understanding of the effects of a single session of intermittent 25 theta burst stimulation (iTBS) on the DMN in healthy subjects is limited. To reduce the effects of 26 inter-individual variability in functional architectures, we used a novel personalized target selection 27 approach based on each subject's resting state fMRI for an unprecedented investigation into the 28 effects of a single session (1800 pulses) of iTBS over the DMN in healthy controls. 26 healthy subjects 29 participated in a double-blind, crossover, sham-controlled study. After iTBS to the personalized left 30 dorsolateral prefrontal cortex (DLPFC) targets, we investigated the time lapse of effects in the DMN 31 and its relationship to the harm avoidance (HA) personality trait measure (Temperament and 32Character Inventory/TCI). Approx. 25-30 minutes after stimulation, we observed reduced FC 33 between the DMN and the rostral anterior cingulate cortex (rACC). About 45 minutes after 34 stimulation the FC of rACC strongly decreased further, as did the FC of right anterior insula (rAI) with 35 the DMN. We also report a positive correlation between the FC decrease in the rACC and the HA 36 domain of TCI. Our results show how iTBS at personalized left-DLPFC targets reduces the FC between 37 DMN and the rACC and rAI, regions typically described as nodes of the salience network. We find 38 that HA scores can potentially predict iTBS response, as has been observed for HF-rTMS. 39 40 41 42 43

show abstract

Baseline effective connectivity predicts response to repetitive transcranial magnetic stimulation in patients with treatment-resistant depression

Cited by 51 publications

References 36 publications

Functional connectivity changes with rapid remission from moderate-to-severe major depressive disorder

Functional connectivity changes with rapid remission from moderate-to-severe major depressive disorder

Encoding, Consolidation, and Renormalization in Depression: Synaptic Homeostasis, Plasticity, and Sleep Integrate Rapid Antidepressant Effects

Intermittent theta burst stimulation at personalized targets reduces the functional connectivity of the default mode network in healthy subjects

Contact Info

Product

Resources

About