Baseline data report of the China Dialysis Outcomes and Practice Patterns Study (DOPPS)

Abstract

The number of patients on hemodialysis (HD) is rapidly increasing in China. As an Asian country with a large number of HD patients, understanding the status of Chinese HD patients has a special significance. We reported here the baseline data for China Dialysis Outcomes and Practice Pattern Study Phase 5 (DOPPS5). The DOPPS is an international prospective, observational cohort study. Patients were restricted to the initial sample of patients who participated in China DOPPS5. We summarized the baseline demographic and clinical data of patients. Results were weighted by facility sampling fraction. 1186 patients were initial patients in China DOPPS5. The mean age was 58.7 ± 3.5 years, with 54.6% males. The median dialysis vintage was 3.4 (1.5, 6.3) years. The main assigned primary end-stage kidney disease (ESKD) causes was chronic glomerulonephritis (45.9%), followed by diabetes (19.9%). 17.6% patients had hepatitis B infection, and 10.0% patients had hepatitis C infection. 25.9% patients had a single-pooled Kt/V < 1.2. 86.6% patients had albumin > 3.5 g/dl. 18.8% patients had hemoglobin < 9 g/dl. 66.5% patients had serum calcium in target range (8.4–10.2 mg/dl), 41.5% patients had serum phosphate in target range (3.5–5.5 mg/dl) and 51.2% patients maintained PTH in 150–600 pg/dl. 88.2% patients used fistula as their vascular access. Meanwhile, there were differences in the demographic, clinical, laboratory, and treatment characteristics among the three cities participated in China DOPPS. We observed a relatively higher albumin level and a higher rate of fistula usage in our patients. But it remains a major challenge to us on the management of CKD-MBD and anemia. This study did not include patients in small cities and remote areas, where the situation of HD patients might be worse than reported.

Thrombocytopenia predicts mortality in Chinese hemodialysis patients- an analysis of the China DOPPS

“…DOPPS China randomly selected an average of 30 patients from 15 dialysis facilities in each city of Beijing, Shanghai, and Guangzhou. This was described in our previous study [ 24 – 26 ]. There were 1427 patients participated in China DOPPS5 (2012–2015).…”

Erythropoietin and iron for anemia in HIV-infected patients undergoing maintenance hemodialysis in China: a cross-sectional study

“…For adult HD patients, KDIGO suggests that ESAs therapy is used to avoid having the Hgb concentration fall below 90 g/L by starting erythropoietin therapy when the Hb is between 90–100 g/L in 2012 [ 19 ]. Our study showed that 11.76% of patients in the HIV-HD group and 5.71% of patients in the HD group had Hgb < 90 g/L, compared with 18.8% patients in China Dialysis Outcomes and Practice Patterns Study (DOPPS) [ 20 ]. The reason for the lower prevalence of Hgb < 90 g/L maybe include younger age, shorter dialysis vintage, higher percentage of males and higher dialysis frequency in enrolled patients in our study (Table 4 ) [ 20 ].…”

“…Our study showed that 11.76% of patients in the HIV-HD group and 5.71% of patients in the HD group had Hgb < 90 g/L, compared with 18.8% patients in China Dialysis Outcomes and Practice Patterns Study (DOPPS) [ 20 ]. The reason for the lower prevalence of Hgb < 90 g/L maybe include younger age, shorter dialysis vintage, higher percentage of males and higher dialysis frequency in enrolled patients in our study (Table 4 ) [ 20 ]. There was no significant difference in Hgb and ferritin between HIV-HD and HD patients in our study.…”

Blood flow rate: An independent risk factor of mortality in Chinese hemodialysis patients

“…DOPPS China randomly selected an average of 30 patients from 15 dialysis facilities in each city of Beijing, Shanghai, and Guangzhou. This was described in our previous studies 16,17 . Inclusion criteria for participants were age ≥18 years, treated at an in‐center dialysis clinic and receiving chronic, maintenance HD.…”

“…This was described in our previous studies. 16,17 Inclusion criteria for participants were age ≥18 years, treated at an in-center dialysis clinic and receiving chronic, maintenance HD. Exclusion criteria: patients <18 years, treated with a home-based dialysis modality or receiving HD for acute kidney injury.…”