Baseline correction by improved iterative polynomial fitting with automatic threshold

Gan, Feng; Ruan, Guihua; Mo, Jinhan

doi:10.1016/j.chemolab.2005.08.009

Cited by 176 publications

(116 citation statements)

References 8 publications

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“…Modification of the windowing analysis may be a local median method [10], which is based on medians local search within a specified window and smoothing points using Gauss weights. Alternatively, an iterative adjustment of the polynomial [11] can be used. …”

Section: Baseline Correctionmentioning

confidence: 99%

Preprocessing Methods in Nuclear Magnetic Resonance Spectroscopy

Staniszewski

Skorupa

Boguszewicz

et al. 2016

Advances in Intelligent Systems and Computing

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Magnetic resonance spectroscopy is currently used in chemistry and medicine as a diagnostic tool. Due to many imperfections that are present during measurement the signal has to be corrected by so called preprocessing methods or techniques. Some of them are performed by a scanner, but it is still necessary to improve the quality of the numerical signal. This paper presents a description of the most important preprocessing techniques which are applied by most current software and is an extension of the most currently reviews presented on this topic.

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Section: Baseline Correctionmentioning

confidence: 99%

Preprocessing Methods in Nuclear Magnetic Resonance Spectroscopy

Staniszewski

Skorupa

Boguszewicz

et al. 2016

Advances in Intelligent Systems and Computing

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“…The functions are usually first-order polynomials; however, higher-order polynomials or a series of connected first-order polynomials are also used in some situations. Having determined the equation of the background signal, the fitted line is then subtracted from the signal (Brereton, 2003;Gan et al, 2006;Kaczmarek et al, 2005;Zhang et al, 2010;Persson & Strang, 2003;Eilers, 2003). Correction of the baseline using curve fitting is demonstrated in Figure 3.…”

Section: Baseline Correctionmentioning

confidence: 99%

Application of Chemometrics to the Interpretation of Analytical Separations Data

Harynuk¹,

Mata²,

Sinkov³

2012

Chemometrics in Practical Applications

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“…The absorption coefficients of the DNA samples included not only the DNA signal but also the baseline signal arising from the other materials used to make the DNA samples. Because the materials included ice, which has higher absorption than the HDPE powder, baseline correction was required to find the resonance in the absorption 55,56 . We used Matlab 2011 and Origin Pro 9, a software package for numerical computation and visualization, to calculate the baseline and to fit the measurement data.…”

Section: Methodsmentioning

confidence: 99%

Terahertz molecular resonance of cancer DNA

Cheon

Son

2017

2017 42nd International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz)

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Carcinogenesis involves the chemical and structural alteration of biomolecules in cells. Aberrant methylation of DNA is a well-known carcinogenic mechanism and a common chemical modification of DNA. Terahertz waves can directly observe changes in DNA because the characteristic energies lie in the same frequency region. In addition, terahertz energy levels are not high enough to damage DNA by ionization. Here, we present terahertz molecular resonance fingerprints of DNA methylation in cancer DNA. Methylated cytidine, a nucleoside, has terahertz characteristic energies that give rise to the molecular resonance of methylation in DNA. Molecular resonance is monitored in aqueous solutions of genomic DNA from cancer cell lines using a terahertz time-domain spectroscopic technique. Resonance signals can be quantified to identify the types of cancer cells with a certain degree of DNA methylation. These measurements reveal the existence of molecular resonance fingerprints of cancer DNAs in the terahertz region, which can be utilized for the early diagnosis of cancer cells at the molecular level.The early detection of cancer is among the most important issues in medical diagnosis because it provides a chance to treat cancer before it grows too large and spreads to other organs 1-3 . Many techniques from a variety of fields have been attempted to achieve early cancer detection, including optical techniques. Of these, terahertz (THz) spectroscopy shows high sensitivity for chemical changes in biological molecules without causing ionization, owing to its low photon energy [4][5][6][7][8] . THz cancer diagnostics have attracted much attention, in particular because the THz technique can distinguish normal tissue from cancer tissues via spectroscopic imaging and has been further improved with nanoparticle contrast agents to achieve higher contrast 9-13 . However, this method is still insufficient for cancer diagnostics because it provides only nonspecific information (location, size, and demarcation) but no molecular or biological information regarding the cancer 1,[14][15][16] . This issue is also present in current medical imaging techniques such as magnetic resonance imaging (MRI), computed tomography (CT) and positron emission tomography (PET). These techniques require contrast agents to enhance detection and cannot provide tumour-specific information. Cancer biomarkers play a significant role in providing molecular information for the specific diagnosis of early-stage cancers 17,18 . In particular, carcinogenesis causes chemical and structural alterations to the DNA in cells, and detecting such changes would be important in identifying cancers. Several groups have attempted to characterize the spectral properties of DNA in the THz frequency range.B. M. Fischer et. al. reported on the THz resonance features of DNA components (nucleobases and deoxynucleosides) using a THz spectroscopic system. M. Brucherseifer et al. measured the differences in the transmission changes and refractive indices of single-and double-stranded DN...

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Baseline correction by improved iterative polynomial fitting with automatic threshold

Cited by 176 publications

References 8 publications

Preprocessing Methods in Nuclear Magnetic Resonance Spectroscopy

Preprocessing Methods in Nuclear Magnetic Resonance Spectroscopy

Application of Chemometrics to the Interpretation of Analytical Separations Data

Terahertz molecular resonance of cancer DNA

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