Baseline characteristics and outcome predictors in patients hospitalized with COVID-19 in the University General Hospital of Ioannina, Greece

Quaranta, Vitaliano Nicola; Kyriakopoulos, Christos; Liontos, Angelos; Barkas, Fotios; Chronis, Christos; Biros, Dimitrios; Athanasiou, L; Milionis, Orestis; Tsourlos, S; Veliani, Cornelia; Papathanasiou, Alexandros; Samanidou, Valentini; Aggelopoulou, Agapi; Bellou, Vanesa; Pappa, Christina; Kolios, Nikolaos-Gavriil; Filippas-Ntekouan, Sempastien; Carpagnano, Giovanna Elisiana; Dragonieri, Silvano; Christaki, Eirini; Konstantinidis, Athanasios; Milionis, Haralampos; Κostikas, Κonstantinos

doi:10.18332/pne/146178

Cited by 2 publications

(2 citation statements)

References 23 publications

(23 reference statements)

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“…In our research sample, we noted a reduced incidence of COPD in patients undergoing AA and spontaneous breathing (9.4%) in contrast to 20% in those receiving different levels of respiratory support (OT: 20%; NIV/CPAP: 20.3%; ETI/TRACHEO: 3.5%). This finding aligns with observations made in previous patient groups, where the significance of COPD as a risk factor for severe COVID-19 was underscored [25,26].…”

Section: Discussionsupporting

confidence: 92%

The Predictors of Long COVID in Southeastern Italy

Quaranta,

Portacci,

Dragonieri

et al. 2023

JCM

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Introduction: Long COVID is now recognized as a common consequence of the SARS-CoV-2 infection, but we are still far from fully understanding its pathogenesis and predictive factors. Many pathophysiological factors have been studied, including ethnicity. To our knowledge, the risk factors for Long COVID have not been studied in Southeastern Italy. Aims: The aim of this study was to evaluate the predictive factors of Long COVID in a cohort of patients from Southeastern Italy. Methods: We conducted a retrospective longitudinal study, enrolling inpatients and outpatients diagnosed with COVID-19 from June 2021 to March 2022. A total of 436 subjects were evaluated in an outpatient setting 12 weeks after a SARS-CoV-2 infection, recording comorbidities, symptoms, therapy, and clinical information. Univariate and multivariate binomial logistic regression analyses were performed on different risk factors to define the probability of developing Long COVID. Results: A total of 71.8% of patients (313) developed Long COVID, while the remaining 123 (28.3%) had a complete remission of symptoms 3 months after acute infection. During the acute phase of COVID-19, 68.3% of patients experienced respiratory failure and 81.4% received corticosteroid therapy. In a multivariate analysis, the female sex (SEX M ODD 0.513) and corticosteroids (ODD 2.25) were maintained as predictive values. Conclusions: From our data and in line with other studies, the female sex emerges as a risk factor for Long COVID in the population of Southeastern Italy. Corticosteroid therapy administered in the acute phase also appears to be associated with an increased risk of Long COVID. Although indications for the prescription of corticosteroid therapy in the acute phase were indicated by the presence of pneumonia complicated by respiratory insufficiency, there was an over-prescription of corticosteroid therapy in the real life of our cohort, with 64% of patients having respiratory insufficiency and 81% having corticosteroid therapy. We hypothesize that a synergistic link between viral infection and the side effects of corticosteroid therapy may arise in selected cases.

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Section: Discussionsupporting

confidence: 92%

The Predictors of Long COVID in Southeastern Italy

Quaranta,

Portacci,

Dragonieri

et al. 2023

JCM

Self Cite

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“…However, COPD management and hospitalization are influenced by various factors 6 , 22 . For example, this study has shown that factors such as COVID-19, malignancy, and cardiovascular disease are associated with more extended hospital stays in COPD patients 23 . Previous research has also demonstrated that smoking cessation can prevent acute exacerbations of COPD, reduce incidence rates, improve survival rates 24 , alleviate respiratory symptoms, improve prognosis, and slow disease progression 25 .…”

Section: Discussionmentioning

confidence: 78%

Smoking cessation and influenza vaccination can reduce the healthcare burden of COPD

Chang,

Liu,

Kuo

et al. 2023

Tob. Induc. Dis.

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INTRODUCTION Influenza vaccination (INV) and smoking cessation (SC) have individual positive effects on COPD, but their synergistic impact has yet to be extensively studied. This retrospective study aimed to assess the combined effect of SC and IV on the medical burden of COPD, including medical visits, hospitalization, medical expenses, and the occurrence of respiratory failure. METHODS Patients with COPD who visited our medical center between January and October 2018 were included in the study. The patients were categorized into four groups: Group I (no SC or INV), Group II (INV only), Group III (SC only), and Group IV (both SC and INV). The outcomes analyzed were emergency utilization, hospital utilization, and occurrence of respiratory failure. Airflow limitation was stratified according to GOLD guidelines, and successful smoking cessation was defined as not smoking for at least one year. RESULTS A total of 357 patients were included in the study. Group I (119 patients) neither smoking cessation nor influenza vaccination; Group II (66 patients) had only influenza vaccination; Group III (94 patients), had only smoking cessation, Group IV (78 patients), with both smoking cessation and influenza vaccination. Group IV had lower odds of emergency utilization (OR=0.13; 95% CI: 0.07–0.25), hospital utilization (OR=0.13; 95% CI: 0.05–0.30, p<0.001), and occurrence of respiratory failure (OR=0.13; 95% CI: 0.04–0.40, p<0.001). CONCLUSIONS Combined smoking cessation and influenza vaccination are more effective in reducing the medical burden of COPD compared to either intervention alone or neither. These findings highlight the importance of promoting both smoking cessation and influenza vaccination in the management of COPD.

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Baseline characteristics and outcome predictors in patients hospitalized with COVID-19 in the University General Hospital of Ioannina, Greece

Cited by 2 publications

References 23 publications

The Predictors of Long COVID in Southeastern Italy

The Predictors of Long COVID in Southeastern Italy

Smoking cessation and influenza vaccination can reduce the healthcare burden of COPD

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