Baseline Antipsychotic Dose and Transition to Psychosis in Individuals at Clinical High Risk
Andrea Raballo,
Michele Poletti,
Antonio Preti
Abstract:ImportanceEmerging meta-analytical evidence indicates that baseline exposure to antipsychotics is associated with an increased risk of transitioning to psychosis in individuals at clinical high-risk for psychosis (CHR-P) and that such effect is not a result of pretest risk enrichment. However, to maximize its translational utility for prognostic stratification in clinical practice, testing for the potential presence of a dose-response association is crucial.ObjectiveTo test whether the negative prognostic effe… Show more
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