Based on Virtual Screening and Simulation Exploring the Mechanism of Plant-Derived Compounds with PINK1 to Postherpetic Neuralgia
Wenjing Guo,
Bo Zhang,
Minchen Liu
et al.
Abstract:Recent studies have found that PINK1 mutation can mediate the dysfunction of mitochondrial autophagy in dopaminergic neurons; In order to reveal the role of PINK1 in the pathogenesis of PHN and nd new targets for PHN treatment. Purpose: Herein, we have employed a rigorous literature review pipeline to enlist 2801compounds from more than 200 plants from the Asian region. The virtual screening procedure helps us to shortlist the total compounds into 20 based on their better binding energy. Moreover, the Prime MM… Show more
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