Based on the Beers Criteria 2019 Edition Over-the-Counter Drugs Risk Confirmation of Elderly Chinese

Yang, Yong‐Yu; Zhang, Lu; Huang, Ya-Min; Huang, Hangxing; Sun, Shusen; Xiao, Jian

doi:10.1155/2021/5524551

Cited by 2 publications

(3 citation statements)

References 24 publications

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“…OTC drugs usually contain prescription drug ingredients with an active effect. Taking OTC drugs and prescription medications at the same time may lead to repeated medications and increase the potential risk of overdose (Yang et al, 2021). In China, OTC drugs accounted for 12.6% of ADEs, among which people over 60 years old accounted for 24.4% (Yang et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

“…Taking OTC drugs and prescription medications at the same time may lead to repeated medications and increase the potential risk of overdose (Yang et al, 2021). In China, OTC drugs accounted for 12.6% of ADEs, among which people over 60 years old accounted for 24.4% (Yang et al, 2021). However, only 45% of Chinese residents had a certain understanding of OTC drugs (Yang et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

“…In China, OTC drugs accounted for 12.6% of ADEs, among which people over 60 years old accounted for 24.4% (Yang et al, 2021). However, only 45% of Chinese residents had a certain understanding of OTC drugs (Yang et al, 2021). In China, clinical pharmacists and doctors rarely intervened in the use of OTC drugs in older adults during non-hospitalization.…”

Section: Discussionmentioning

confidence: 99%

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Geriatrician-led multidisciplinary team management improving polypharmacy among older inpatients in China

et al. 2023

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Background/Aim: Polypharmacy is prevalent among older inpatients and associated with adverse outcomes. To determine whether a geriatrician-led multidisciplinary team (MDT) management mode could reduce medications use among older inpatients.Methods: A retrospective cohort study was conducted in a geriatric department of a tertiary hospital in China with 369 older inpatients, including 190 patients received MDT management (MDT cohort), and 179 patients received usual treatment (non-MDT cohort). The primary outcome was to compare the changes of the amount of medications before and after hospitalization in two cohorts.Results: We reported that MDT management significantly reduced the number of medications used in older inpatients at discharge (at home: n = 7 [IQR: 4, 11] vs at discharge: n = 6 [IQR: 4, 8], p < 0.05). Hospitalization with the MDT management had a significant effect on the change in the amount of medications (F = 7.813, partial-η2 = 0.011, p = 0.005). The discontinuance of medications was associated with polypharmacy at home (OR: 96.52 [95% CI: 12.53-743.48], p < 0.001), and the addition of medications was associated with a diagnosis of chronic obstructive pulmonary disease (COPD) (OR: 2.36 [95% CI: 1.02-5.49], p = 0.046).Conclusion: The results indicated that the geriatrician-led MDT mode during hospitalization could reduce the number of medications used by older patients. The patients with polypharmacy were more likely to “deprescription” after MDT management, while the patients with COPD were more likely to be under-prescription at home, polypharmacy which could be made up for after MDT management.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Geriatrician-led multidisciplinary team management improving polypharmacy among older inpatients in China

et al. 2023

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Scutellaria barbata D. Don inhibits cervical cancer cell proliferation, migration, and invasion via miR-195-5p/LOXL2 axis

Xue

Geng²,

Lian

et al. 2022

Toxicology Research

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Background Scutellaria barbata D. Don (SB) is a widely used herbal medicine in China, with various pharmacological effects such as anti-oxidation, anti-inflammation, and anti-cancer. This work is aimed to investigate the tumor-suppressive effect of SB in cervical cancer (CC) and to identify its underlying mechanisms. Methods and materials CC cell lines (HeLa and HT-3) were treated with different concentrations of SB chloroform extract (ECSB) (0, 0.2, 0.5 mg/ml). MiR-195-5p and LOXL2 mRNA expression in CC cell lines and tissue samples was detected by quantitative real-time polymerase chain reaction. Cell counting kit-8 experiment was utilized to examine cell viability; TUNEL assay and Transwell experiment was executed to examine cell apoptosis, migration, and invasion. Western blotting experiments were implemented to detect LOXL2 protein expression. Bioinformatics and dual-luciferase reporter gene experiment were executed to examine the binding relationship between miR-195-5p and LOXL2. Results ECSB repressed the viability, migration, and invasion of HeLa and HT-3 cells, and promoted cell apoptosis in a dose-dependent manner. MiR-195-5p was remarkably under-expressed in CC tissues and cells, and ECSB up-regulated miR-195-5p expression. MiR-195-5p inhibitors partially counteracted the suppressive effects of ECSB on the malignant phenotypes of HeLa and HT-3 cells. LOXL2 was a downstream target of miR-195-5p, and ECSB up-modulated LOXL2 expression by specifically repressing miR-195-5p. Conclusion SB restrains CC cell proliferation and metastasis and promotes cell apoptosis via miR-195-5p/LOXL2, which may be a potential therapeutic agent for CC treatment.

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Based on the Beers Criteria 2019 Edition Over-the-Counter Drugs Risk Confirmation of Elderly Chinese

Cited by 2 publications

References 24 publications

Geriatrician-led multidisciplinary team management improving polypharmacy among older inpatients in China

Geriatrician-led multidisciplinary team management improving polypharmacy among older inpatients in China

Scutellaria barbata D. Don inhibits cervical cancer cell proliferation, migration, and invasion via miR-195-5p/LOXL2 axis

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